Katrin Milger
A5039583899- Asthma and respiratory diseases
- Pulmonary Hypertension Research and Treatments
- Respiratory and Cough-Related Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Transplantation: Methods and Outcomes
- Allergic Rhinitis and Sensitization
- Pediatric health and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Health and Medical Studies
- Vascular Anomalies and Treatments
- Neonatal Respiratory Health Research
- IL-33, ST2, and ILC Pathways
- Respiratory viral infections research
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Respiratory Support and Mechanisms
- Eosinophilic Disorders and Syndromes
- Eosinophilic Esophagitis
- Renal Transplantation Outcomes and Treatments
- Pharmaceutical studies and practices
- COVID-19 Clinical Research Studies
- Cardiovascular Issues in Pregnancy
- Lung Cancer Treatments and Mutations
- High Altitude and Hypoxia
German Center for Lung Research
2016-2025
LMU Klinikum
2016-2025
Ludwig-Maximilians-Universität München
2016-2025
Asklepios Fachkliniken München-Gauting
2014-2025
Medical University of Graz
2024-2025
Helmholtz Zentrum München
2013-2023
Zentrum für Rhinologie und Allergologie
2023
Praxis
2023
Klinikum Stuttgart
2023
Düsseldorf University Hospital
2023
BackgroundPulmonary hypertension (PH) is a severe, progressive disease. Although 5 PH subgroups are recognized, reports on survival have focused mainly pulmonary arterial (PAH).MethodsLong-term transplant-free and its determinants were investigated in patients with (diagnosed by right heart catheterization) within prospective registry at single referral center Giessen, Germany.ResultsIn total, 2,067 enrolled (PAH, 685 [33.1%]; venous hypertension, 307 [14.9%]; due to lung diseases (LD-PH),...
Risk stratification plays an essential role in the management of patients with pulmonary arterial hypertension (PAH). The current European guidelines propose a three-stratum model to categorise risk as low, intermediate or high, based on expected 1-year mortality. However, this model, most are categorised risk. We investigated modified approach four categories, subdivided into intermediate-low and intermediate-high risk.We analysed data from Comparative, Prospective Registry Newly Initiated...
The term idiopathic pulmonary arterial hypertension (IPAH) is used to categorize patients with pre-capillary of unknown origin. There considerable variability in the clinical presentation these patients.Using data from Comparative, Prospective Registry Newly Initiated Therapies for Pulmonary Hypertension, we performed a cluster analysis 841 IPAH based on age, sex, diffusion capacity lung carbon monoxide (DLCO; <45% vs ≥45% predicted), smoking status, and presence comorbidities (obesity,...
BackgroundAmong patients meeting diagnostic criteria for idiopathic pulmonary arterial hypertension (IPAH), there is an emerging lung phenotype characterised by a low diffusion capacity carbon monoxide (DLCO) and smoking history. The present study aimed at detailed characterisation of these patients.MethodsWe analysed data from two European registries, COMPERA (launched in 2007) ASPIRE (from 2001 onwards), to identify diagnosed with IPAH defined DLCO less than 45% predicted We compared...
Zusammenfassung Das Management von Asthma hat sich in den letzten Jahrzehnten fundamental gewandelt. Die vorliegende Leitlinie zur Diagnostik und Therapie wurde für pneumologisch tätige Fachärztinnen Fachärzte entwickelt, welche detaillierte evidenzbasierte Informationen zu neuen diagnostischen therapeutischen Optionen benötigen. zeigt die neue Bedeutung der Biomarker, insbesondere Bluteosinophilen des exhalierten NO (FeNO), Algorithmen Asthma. Als erste Asthma-Leitlinie weltweit benennt...
Long-chain fatty acids are important metabolites for the generation of energy and biosynthesis lipids. The molecular mechanism their cellular uptake has remained controversial. acid transport protein (FATP) family been named according to its proposed function in mediating this process at plasma membrane. Here, we show that FATP4 is fact localized endoplasmic reticulum not membrane as reported previously. Quantitative analysis confirms positive correlation between expression acids. However,...
Since 2015, the European pulmonary hypertension guidelines recommend use of combination therapy in most patients with arterial (PAH). However, it is unclear to what extent this treatment strategy adopted clinical practice and if associated improved long-term survival.We analysed data from COMPERA, a large registry, assess temporal trends survival newly diagnosed PAH between 2010 2019. For analyses, we looked at annualised cumulated comparing periods 2010-2014 2015-2019.A total 2531 were...
Recently, criteria for evaluation of response to biologics have been proposed and the concept clinical remission has gained attention as a possible goal even in severe asthma.To analyze German Asthma Net asthma registry cohort.We included adults not using biologic at baseline (V0) compared patients treated between V0 1-year visit (V1) without (group A) starting with after continuing it up V1 B). We applied Biologics Response Score quantify composite good, intermediate, or insufficient....
<b><i>Background:</i></b> Nintedanib is approved for the treatment of idiopathic pulmonary fibrosis (IPF) and has been shown to slow disease progression by reducing annual lung function decline. <b><i>Objective:</i></b> To evaluate results a large cohort IPF patients treated with nintedanib within compassionate use program (CUP) in Germany (9 centers). <b><i>Methods:</i></b> Patients (≥40 years) were required have...
A fraction of COVID-19 patients progress to a severe disease manifestation with respiratory failure and the necessity mechanical ventilation. Identifying at risk is critical for optimised care early therapeutic interventions. We investigated dynamics acute syndrome coronavirus 2 (SARS-CoV-2) shedding relative severity. analysed nasopharyngeal tracheal SARS-CoV-2 in 92 diagnosed COVID-19. Upon admission, standardised swab or sputum samples were collected. If mechanically ventilated,...
Background Virus infections drive COPD exacerbations and progression. Antiviral immunity centres on the activation of virus-specific CD8 + T-cells by viral epitopes presented major histocompatibility complex (MHC) class I molecules infected cells. These are generated immunoproteasome, a specialised intracellular protein degradation machine, which is induced antiviral cytokines in Methods We analysed effects cigarette smoke cytokine- virus-mediated induction immunoproteasome vitro , ex vivo...
Abstract Objectives Pulmonary arterial hypertension (PAH) occurs in various connective tissue diseases (CTDs). We sought to assess contemporary treatment patterns and survival of patients with forms CTD-PAH. Methods analysed data from COMPERA, a European pulmonary registry, describe strategies newly diagnosed PAH associated SSc, SLE, MCTD, UCTD other types CTD. All-cause mortality was according the underlying For SSc-PAH, we also assessed initial therapy endothelin receptor antagonists...
Abstract Background Asthma is a heterogeneous chronic disease with different phenotypes and treatment responses. Thus, there high clinical need for molecular biomarkers to aid in differentiating these distinct phenotypes. As Micro RNA s (mi s), that regulate gene expression at the post‐transcriptional level, are altered experimental human asthma, circulating mi attractive candidates identification of novel biomarkers. This study aimed identify plasmatic ‐based through translational approach....
Evaluation of pulmonary function impairment after COVID-19 in persistently symptomatic and asymptomatic patients all disease severities characterisation risk factors.Patients with confirmed SARS-CoV-2 infection underwent prospective follow-up testing blood gas analysis during steady-state cycle exercise 4 months acute illness. Pulmonary (PFI) was defined as reduction below 80% predicted DLCOcSB, TLC, FVC, or FEV1. Clinical data were analyzed to identify factors for impaired function.76...