A5001538826- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Alzheimer's disease research and treatments
- Blood Coagulation and Thrombosis Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- Cell Adhesion Molecules Research
- S100 Proteins and Annexins
- Peroxisome Proliferator-Activated Receptors
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Protein Hydrolysis and Bioactive Peptides
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Transplantation: Methods and Outcomes
- Signaling Pathways in Disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal Respiratory Health Research
- Inflammasome and immune disorders
- Liver Disease Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Immune Response and Inflammation
- Antimicrobial Peptides and Activities
- Heme Oxygenase-1 and Carbon Monoxide
- Endoplasmic Reticulum Stress and Disease
- Dementia and Cognitive Impairment Research
Medizinische Hochschule Hannover
2016-2025
German Center for Lung Research
2016-2025
Clinica de Pneumologie Iaşi
2021-2024
Lund University
2002-2022
Leiden University Medical Center
2020
ERN GUARD-Heart
2020
Malmö University
1995-2016
University of Cambridge
2013
Respiratory Clinical Trials
2013
Philipps University of Marburg
2012
Significance The NLRP3 inflammasome is an intracellular oligomer regulating the activation of caspase-1 for processing and secretion IL-1β IL-18. Although there growing evidence to substantiate inhibition as a therapeutic option treatment inflammatory diseases, date, are no approved humans agents. OLT1177, β-sulfonyl nitrile molecule, shown be safe in humans, selective inhibitor inflammasome, with unique properties reverse metabolic costs inflammation treat IL-1β– IL-18–mediated diseases.
Chemokine (C-C motif) receptor 2 (CCR2)-signaling can mediate accumulation of microglia at sites affected by neuroinflammation. CCR2 and its main ligand CCL2 (MCP-1) might also be involved in the altered metabolism beta-amyloid (Aβ) underlying Alzheimer's disease (AD). We therefore measured levels three other ligands, i.e. CCL11 (eotaxin), CCL13 (MCP-4) CCL26 (eotaxin-3), cerebrospinal fluid (CSF) plasma 30 controls 119 patients with mild cognitive impairment (MCI) baseline. During clinical...
The rationale of α1-antitrypsin (AAT) augmentation therapy to treat progressive emphysema in AAT-deficient patients is based on inhibition neutrophil elastase; however, the benefit this treatment remains unclear. Here we show that clinical grade AAT (with elastase inhibitory activity) and a recombinant form (rAAT) without anti-elastase activity reduces lung inflammatory responses LPS elastase-deficient mice. WT mice treated with either native or rAAT exhibited significant reductions...
Interleukin-3 (IL-3) is capable of supporting the proliferation a broad range hematopoietic cell types, whereas granulocyte colonystimulating factor (G-CSF) and macrophage CSF (M-CSF) represent critical cytokines in myeloid differentiation.When this was investigated pluripotent-stem-cell-based differentiation model, IL-3/G-CSF or IL-3/M-CSF exposure resulted continuous generation cells from an intermediate myeloid-cell-forming complex containing CD34 + clonogenic progenitor for more than 2...
Accumulation and oxidation of LDL are believed to be important initiating factors in atherosclerosis. Oxidized is recognized by the immune system, animal studies have suggested that these responses a protective effect against Aldehyde-modified peptide sequences apolipoprotein B-100 (apoB-100) major targets for responses.Human IgG1 antibodies 2 malondialdehyde (MDA)-modified apoB-100 were produced through screening single-chain antibody-fragment library subsequent cloning into pcDNA3 vector....
Human monocytes are a heterogeneous cell population classified into three different subsets: Classical CD14++CD16-, intermediate CD14++CD16+, and non-classical CD14+CD16++ monocytes. These subsets distinguished by their differential expression of CD14 CD16, unique gene profile. So far, the variation in inter-cellular within monocyte is largely unknown. In this study, cellular each human subset from single healthy donor was described using novel single-cell PCR gene-expression analysis tool....
It has been suggested that a number of molecules associated with inflammation are involved in the pathogenesis Alzheimer’s disease (AD). We measured levels α<sub>1</sub>-antichymotrypsin (ACT), α<sub>1</sub>-antitrypsin (AAT), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1) and oxidised low-density lipoprotein (oxLDL) matched cerebrospinal fluid (CSF) plasma 141 patients probable AD. found significant relationship between CSF ACT (r = 0.4, p <...
The major component of the cerebral plaques in Alzheimer disease is beta-amyloid peptide, but serine proteinase inhibitors like alpha 1-antichymotrypsin (ACT) are also present. Their role pathogenesis amyloid formation unsettled. In addition to their function as inhibitors, can interact with various hydrophobic compounds, a reaction accompanied by transition from stressed relaxed conformation. We report here on ability ACT regulate fibrils vitro. molar ratio 1:10 (ACT beta-amyloid) inhibits...
Serine protease inhibitors (serpins), the acute phase reactants and regulators of proteolytic processing proteins, have been recognized as potential contributors to pathogenesis Alzheimer disease (AD). We measured plasma CSF levels serpins in controls patients with dementia.Using rocket immunoelectrophoresis, ELISA, Luminex xMAP technology, we analyzed alpha(1)-antichymotrypsin alpha(1)-antitrypsin, alpha(1)-antichymotrypsin, neuroserpin along three standard biomarkers (total tau, tau...
Section:ChooseTop of pageAbstract <<MATERIALS AND METHODSRESULTSDISCUSSIONReferencesCITING ARTICLES
Matrix metalloproteinases (MMP) are believed to be involved in the pathologic processes behind Alzheimer's disease (AD). In this study, we aimed examine cerebrospinal fluid (CSF) levels of MMPs and tissue inhibitors metalloproteinase-1 (TIMP-1) individuals with AD dementia cognitively healthy elderly individuals, investigate their relationship established CSF biomarkers for disease.CSF was collected from 38 34 individuals. The analyzed MMP-1, MMP-3, MMP-9, TIMP-1, beta-amyloid1-42 (Abeta42),...
Abstractα1-antitrypsin (AAT) is a serine protease inhibitor, which recently has been shown to prevent type 1 diabetes (T1D) development, prolong islet allograft survival and inhibit β-cell apoptosis in vivo. It also reported that T1D patients have significantly lower plasma concentrations of AAT suggesting the potential role pathogenesis T1D. We investigated whether plasma-purified can affect function vitro. INS-1E cells or primary rat pancreatic islets were used study effect on insulin...
α 1 -Antitrypsin deficiency (AATD) is a genetically determined disorder that associated with different clinical manifestations. We aimed to assess the prevalence of diagnosed AATD and its comorbidities using large healthcare database. In this retrospective longitudinal observational study, we analysed data from 4 million insurants. Using International Classification Diseases revision 10 (ICD-10) codes, assessed prevalence, utilisation patients (E88.0 repeatedly coded) relative non-AATD...