A5040403052- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Obstructive Sleep Apnea Research
- Sarcoidosis and Beryllium Toxicity Research
- Respiratory Support and Mechanisms
- Pediatric health and respiratory diseases
- COVID-19 Clinical Research Studies
- Nutrition and Health Studies
- Cystic Fibrosis Research Advances
- Medical Imaging and Pathology Studies
- Gut microbiota and health
- Long-Term Effects of COVID-19
- Asthma and respiratory diseases
- Congenital Diaphragmatic Hernia Studies
- COVID-19 and Mental Health
- Advanced Biosensing Techniques and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Public health and occupational medicine
- Renewable energy and sustainable power systems
- Drug-Induced Adverse Reactions
- Biosensors and Analytical Detection
- Inhalation and Respiratory Drug Delivery
- High Altitude and Hypoxia
- Advanced biosensing and bioanalysis techniques
Ninewells Hospital
2024
University of Dundee
2024
Istanbul University-Cerrahpaşa
2024
Light Prescriptions Innovators (Spain)
2024
COPE Galway
2024
Vlaamse Vereniging voor Obstetrie en Gynaecolo
2024
Masih Daneshvari Hospital
2014-2021
Screen
2021
Instytut Gruźlicy i Chorób Płuc
2002-2014
Background International guidelines recommend airway clearance management as one of the important pillars bronchiectasis treatment. However, extent to which is used for people with in Europe unclear. The aim study was identify use patients across different countries and factors influencing use. Methods This a prospective observational using data from European Multicentre Bronchiectasis Audit Research Collaboration (EMBARC) Registry between January 2015 April 2022. Prespecified options were...
Chronic obstructive pulmonary disease (COPD) is associated with airway inflammation and bacterial dysbiosis. The relationship between the microbiome bronchial gene expression in COPD poorly understood. We aimed to identify differences from brushings patients healthy individuals investigate whether any distinguishing bacteria are related expression.For this 16S rRNA sequencing host transcriptomic analysis, aged 45-75 years mild-to-moderate either receiving or not inhaled corticosteroids same...
Asthma is commonly reported in patients with a diagnosis of bronchiectasis.
Background A validated 4-point sputum colour chart can be used to objectively evaluate the levels of airway inflammation in bronchiectasis patients. In European Bronchiectasis Registry (EMBARC), we tested whether would associated with disease severity and clinical outcomes. Methods We a prospective, observational registry adults conducted 31 countries. Patients who did not produce spontaneous were excluded from analysis. The Murray was at baseline follow-up visits. Key outcomes frequency...
EvA (Emphysema versus Airway disease) is a multicentre project to study mechanisms and identify biomarkers of emphysema airway disease in chronic obstructive pulmonary (COPD). The objective this was delineate objectively imaging-based emphysema-dominant disease-dominant phenotypes using quantitative computed tomography (QCT) indices, standardised with novel phantom-based approach. 441 subjects COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages 1–3) were assessed terms...
Abstract Background Whether the clinical or pathophysiologic significance of “treatable trait” high blood eosinophil count in COPD is same as for asthma remains controversial. We sought to determine relationship between count, characteristics and gene expression from bronchial brushings asthma. Methods Subjects were recruited into a (emphysema versus airway disease [EvA]) cohort (Unbiased BIOmarkers PREDiction respiratory outcomes, U‐BIOPRED). determined using RNAseq EvA (n = 283) Affymetrix...
Background Tuberculosis (TB) is a complex disease associated with other medical conditions, that may affect severity. This study aimed to investigate the impact of comorbidities on treatment outcomes and mortality rates in patients TB Poland. Methods We analyzed national cohort 19,217 adult diagnosed between 2011 2016 compared success those without assess various these outcomes. Odds ratios (OR) were calculated quantify association Results Patients had lower higher rates. Diabetes was...
Rapid and accurate detection identification of pathogens in clinical samples is essential for all infection diseases. However, the case epidemics, it plays a key role not only implementation effective therapy but also limiting spread epidemic. In this study, we present application two nucleic acid isothermal amplification methods-reverse transcription helicase dependent (RT-HDA) reverse loop-mediated (RT-LAMP)-combined with lateral flow assay as tools rapid SARS-CoV-2, etiological agent...
The 2022 invasion of Ukraine by the Russian Federation triggered a refugee crisis, affecting multidrug-/rifampicin-resistant TB (MDR/RR-TB) prevalence in neighbouring countries. This study examines epidemiological trends and characteristics MDR/RR-TB patients Poland, focusing on relative contribution Ukrainian refugees. Data from Polish National Tuberculosis Registry EPIC Project database, covering cases reported between 2010 Q1 2024, were analysed. included 794 cases, showing demographic...
The aim of this study was to identify the frequency and prevalence comorbidities in sarcoid patients assess their influence on overall mortality cohort with sarcoidosis.A 557 histologically confirmed sarcoidosis diagnosed between 2007 2011 a group non-sarcoid controls were observed. All carefully observed for mortality.291 males (52.2%) 266 females (47.8%) mean age 48.4 ± 12.0 years 100 (49.25 10.3) number both groups similar (0.9 0.99 vs 0.81 0.84 NS). thyroid disease significantly higher...
Background Changes in microbial community composition the lung of patients suffering from moderate to severe COPD have been well documented. However, knowledge about specific microbiome structures human associated with CT defined abnormalities is limited. Methods Bacterial derived brush samples lungs 16 different subtypes and 9 healthy subjects was analyzed using a cultivation independent barcoding approach applying 454-pyrosequencing 16S rRNA gene fragment amplicons. Results We could show...
Wstęp: Kortykosteroidoterapia jest według aktualnych wytycznych WASOG/ATS/ERS leczeniem pierwszego rzutu u chorych na przewlekłą sarkoidozę. Jest to leczenie obarczone wysokim ryzykiem wystąpienia objawów ubocznych, które pogarszają rokowanie odległe. J ednocześnie nie ma pewności, że glikokortykosteroidy (GKS) modyfikują naturalny przebieg choroby. Celem pracy była ocena skuteczności i bezpieczeństwa leczenia metotreksatem (MTX) w monoterapii sarkoidozę płucną. Materiał metody: Do...
The EvA study is a European Union-funded project under the Seventh Framework Programme (FP7), which aims at defining new markers for chronic obstructive pulmonary disease (COPD) and its subtypes. acronym derived from emphysema versus airway disease, indicating that targets these two main phenotypes of disease. based on concept are governed by different pathophysiological processes, driven genes have differential gene expression in lung. To define genes, patients non-COPD controls recruited...
<h3>Background:</h3> The external intercostal muscles are chronically exposed to increased inspiratory loading and continuous hypoxia-reoxygenation cycles in patients with obstructive sleep apnoea syndrome (OSAS). It was therefore hypothesised that oxidative stress levels would be these muscles, treatment positive airway pressure (CPAP) modify the improve muscle dysfunction. <h3>Methods:</h3> A case-control study a case-case were conducted on of 12 severe OSAS (before after 6 months CPAP)...
The aim of this study was to assess relationships chronic obstructive pulmonary disease (COPD) comorbidities number, with the duration hospital stay due acute AE COPD in longitudinal prospective study.We evaluated number re-hospitalizations, length and 464 consecutive patients admitted tertiary respiratory enrolled from 2005 2009 year.GOLD II stage had 4.1 ± 1.2 (p = 0.002), III 3.4 1.3 IV 3.6 comorbidities. Duration (medians) longer more severe patients. hospitalization correlated urea...
Abstract Chronic obstructive pulmonary disease (COPD) is a destructive inflammatory and the genes expressed within lung are crucial to its pathophysiology. We have determined RNAseq transcriptome of bronchial brush cells from 312 stringently defined ex-smoker patients. Compared healthy controls there were for males 40 differentially (DEGs) 73 DEGs females with only 26 shared. The gene ontology (GO) term “response bacterium” was shared, several different contributing in females. Strongly...
Background.Bronchiectasis is a progressive chronic disease associated with an increased risk of mortality.Objectives.To identify the prevalence comorbidities in patients bronchiectasis and impact these on mortality. Materials methods.A cohort 93 computed tomography (CT)-confirmed admitted consecutively to tertiary teaching hospital was observed over period 5 years.All were carefully for mortality.Results.A total 43 men (46.2%) 50 women (53.8%) median age 66.0 years (interquartile range (IQR)...
Sarcoidosis as a chronic condition of immune dysregulation might be associated with increased risk venous thromboembolism (VTE). In this study we report three cases sarcoidosis and pulmonary embolism (PE) occurring together, that share common clinical, serological pathological findings, confirming the diagnosis active no others co-existing prothrombotic factors. We hypothesized hypercoagulability for VTE in may attributable to local generalized inflammatory process. The possible relation...
Plywaczewski, R; Sliwinski, P; Nowinski, A; Kaminski, D; Zielinski, JEditor(s): Cannistra, Lauralyn MD; Carlin, Brian Keteyian, Steven J. PhD
Introduction: The aim of this study was to evaluate the effect CPAP treatment on respiratory muscle strength and exercise tolerance in patients with obstructive sleep apnoea (OSA) overlap syndrome (OS). Material methods: 9 OSA OS were studied. Respiratory assessment, 6 minute walking distance (6MWD) cycloergometry test performed before after six month period treatment. Results: In group did not change Mean 6MWD 571.8 ± 76.6 m 554.0 125.5 treatment, mean Wmax 142 41 W 139 38 PImax...
Introduction: Dyspnoea and decreased exercise tolerance are symptoms of acute exacerbation chronic obstructive pulmonary disease (AECOPD). Anaemia is a risk factor for reduced functional capacity dyspnoea in stable COPD. There limited information about the impact anaemia on patients during AECOPD. The aim this study was to evaluate blood haemoglobin concentration results six-minute walking test (6MWT) Material methods: A post hoc analysis data collected from prospective long-term studies...