A5047099627- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- Respiratory Support and Mechanisms
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Sarcoidosis and Beryllium Toxicity Research
- Systemic Sclerosis and Related Diseases
- Histiocytic Disorders and Treatments
- Nutrition and Health Studies
- Asthma and respiratory diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Delphi Technique in Research
- COVID-19 and healthcare impacts
- Pleural and Pulmonary Diseases
- Respiratory and Cough-Related Research
- Lymphatic Disorders and Treatments
- Catholicism, Bioethics, Media, Education
- Public health and occupational medicine
- Infection Control and Ventilation
- Actinomycetales infections and treatment
- Social Issues in Poland
- Building energy efficiency and sustainability
Instytut Gruźlicy i Chorób Płuc
2006-2020
Masih Daneshvari Hospital
2014-2015
Łukasiewicz Research Network
2011
Idiopathic pulmonary fibrosis (IPF) is a rare disorder concerning elderly people, predominantly men, active or former smokers, with progressive nature and leading to premature mortality. The cause of the disease unknown. However, there are some risk factors, among which genetic predisposition plays role. aim our single-centered observational study was assess correlation between single nucleotide polymorphism (SNP) MUC5B gene (rs35705950) course, antifibrotic treatment effect, survival in...
Wstęp: Kortykosteroidoterapia jest według aktualnych wytycznych WASOG/ATS/ERS leczeniem pierwszego rzutu u chorych na przewlekłą sarkoidozę. Jest to leczenie obarczone wysokim ryzykiem wystąpienia objawów ubocznych, które pogarszają rokowanie odległe. J ednocześnie nie ma pewności, że glikokortykosteroidy (GKS) modyfikują naturalny przebieg choroby. Celem pracy była ocena skuteczności i bezpieczeństwa leczenia metotreksatem (MTX) w monoterapii sarkoidozę płucną. Materiał metody: Do...
Pulmonary hypertension (PH) is a well-recognised complication of interstitial lung diseases (ILD), which worsens prognosis and impairs exercise capacity. Echocardiography the most widely used, non-invasive method for PH assessment. The aim our study was to identify factors predictive echocardiographic signs in newly recognised ILD patients.
Hypersensitivity pneumonitis (HP) is an exposure-related interstitial lung disease with two phenotypes-fibrotic and non-fibrotic. Genetic predisposition important factor in the pathogenesis fibrosis development. Several genes are supposed to be associated fibrosing cascade lungs. One of best-recognized most prevalent common MUC5B gene promoter region polymorphism variant rs35705950. The aim our study was establish frequency minor allele population patients HP find relationship between...
Restriction is a typical functional abnormality in interstitial lung disease (ILD) patients, but not always present, especially the early stage of disease. The greater reduction vital capacity (VC; %pred.) than total (TLC; regarded as pattern function disturbances ILD patients.To explore diagnostic value spirometry detection restrictive relative volume loss assessed by TLC and VC large series patients with diagnosis referred for tests was evaluated.Retrospective, cross-sectional analysis...
Decreased diffusing capacity of the lung for carbon monoxide (DLCO) is observed in some idiopathic pulmonary arterial hypertension (IPAH) patients, but its clinical significance uncertain. We aimed to assess correlates and prognostic low DLCO IPAH patients.In group 65 patients cut off value was set up based on histogram as < 55% predicted value. Demographic data, exercise capacity, function tests, hemodynamic parameters survival were compared depending value.Low found 18% it associated with...
In patients with chronic obstructive pulmonary disease, respiratory infections are of various aetiology, predominantly viral and bacterial. However, due to structural immunological changes within the system, such also prone mycobacterial other relatively rare infections. We present 70-year old male patient disease (COPD) coexisting bronchial asthma, diagnosed cough purulent sputum expectoration lasting over three months. The first microbiological investigation sample revealed growth...
Hypersensitivity pneumonitis (HP) is one of the interstitial lung diseases with clearly established diagnostic criteria. Nevertheless, pharmacologic treatment recommendations are still lacking. Most specialists use steroids as first-line drugs, sometimes combined an immunosuppressive agent. Aim: The aim present retrospective study was to establish predictive factors for success and survival advantage in HP patients. Methods: We analyzed short-term outcome overall consecutive patients treated...
This guidance provides advice to healthcare workers on the use of spirometry during SARS-CoV-2 outbreak [...]
Development of sarcoidosis-associated pulmonary hypertension (SAPH) significantly worsens prognosis in sarcoidosis patients. Unfortunately, there is no treatment proven benefit for this condition. Medications used arterial are great interest respect. Here, we report a case patient with severe SAPH treated sildenafil. A significant, but only temporary improvement functional status was observed, and the died gradually progressing heart respiratory failure while awaiting lung transplantation.
Chronic lung diseases are one of the most frequent causes pulmonary hypertension (PH). The diagnostic challenge is to differentiate PH due chronic disease from arterial (PAH) with coexisting disease. Moreover, dominating cause may change over time, requiring implementation new procedures and treatment modalities. We present a 68-year-old female, initially diagnosed in course interstitial disease, restrictive impairment function. Therapy immunosuppressive drugs resulted significant clinical,...
The risk stratification in idiopathic pulmonary arterial hypertension (IPAH) patients is currently based on haemodynamic and functional parameters as well serum biomarker concentrations. Until now the importance of changes appearing high-resolution computed tomography (HRCT) lungs with IPAH has not been investigated.Lung HRCT scans were analysed retrospectively 48 (patients): 37 women, 11 men, mean age 41 +/- 15 years.Focal ground-glass opacifications (FGG) found 12 (25%), centrilobular...
Hypersensitivity pneumonitis (HP) is the third, according to frequency, interstitial lung disease, with estimated incidence rate of 1-2/100,000. In HP patients, extensive inflammatory lesions encompassing both small airways and parenchyma, as well subsequent development fibrosis, may result in respiratory insufficiency secondary pulmonary hypertension (PH). The aim present retrospective study was assess prevalence echocardiographic signs PH its' clinical predictors, newly recognized...
Primary biliary cirrhosis (PBC) is a chronic autoimmune disorder of unknown etiology. The disease affects middle-aged women and characterized by the destruction intralobular bile ducts that causes consequent cholestasis. AMA hallmark PBC, composed mostly IgG IgM class. M2 antibody most specific one, with sensitivity range 54–98% depending on type test used. PBC often accompanied other diseases, such as Sjøgrens syndrome, thyroiditis, rheumatoid arthritis, dermatomyositis, polymyositis....
<b>Introduction:</b> Lung diffusion capacity for carbon monoxide (DLCO) impairment is often in IPAH patients (pts), and it can be profound some of them. <b>Objectives:</b> To assess the degree DLCO impairment, its correlates with other parameters, prognostic significance IPAH. <b>Methods:</b> 65 pts (49 women 16 men, median age 43 years) were allocated to one two groups depending on DLCO% pred.value. Pts DLCO<55% pred. considered have low compared remaining regard functional status...