A5072654925- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Eosinophilic Esophagitis
- Probiotics and Fermented Foods
- Infant Nutrition and Health
- Pediatric health and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Contact Dermatitis and Allergies
- Digestive system and related health
- Protein Hydrolysis and Bioactive Peptides
- Immune Cell Function and Interaction
- Fatty Acid Research and Health
- Dermatology and Skin Diseases
- T-cell and B-cell Immunology
- Eosinophilic Disorders and Syndromes
- Infant Health and Development
- Birth, Development, and Health
- Animal health and immunology
- Respiratory viral infections research
- Mast cells and histamine
- Cholesterol and Lipid Metabolism
- Respiratory and Cough-Related Research
- Gut microbiota and health
- Proteins in Food Systems
Utrecht University
2015-2024
Nutricia Research (Netherlands)
2015-2024
Danone (Netherlands)
2012-2024
Danone Nutricia Research (Netherlands)
2018-2024
Danone (France)
2024
Pharmo Institute
2008-2013
New York University Press
2011
Cambridge University Press
2011
Chitose Institute of Science and Technology
2011
University of Hertfordshire
2011
Background and Aim: Previously, we found that short chain fatty acids (SCFA) inhibit LPS or TNFα-induced endothelial inflammatory responses excessive vascular cell adhesion molecule-1 (VCAM-1) expression, two important steps in the development of atherosclerosis. However, mechanisms involved are still unclear. We hypothesized effects SCFA associated with activation G-protein coupled receptor 41/43 (GPR41/43) and/or inhibition histone deacetylases (HDACs). Methods: The expression location...
In this study the role of interleukin (IL)4, IL5, interferon (IFN) gamma, and tumor necrosis factor (TNF) alpha in development airway hyperresponsiveness inflammatory cell infiltration was investigated using a murine model for allergic asthma. Mice were sensitized with ovalbumin subsequently challenged repeatedly aerosols. During challenge period, mice treated monoclonal antibodies directed against IL4, IFN or TNF alpha. Control antibody-treated showed to methacholine presence eosinophils...
Abstract 1α,25-Dihydroxyvitamin D3 (1,25(OH)2D3), a potent inhibitor of NF-κB expression, can prevent the maturation dendritic cells in vitro leading to tolerogenic with increased potential induce regulatory T cells. Herein, we investigated whether combination allergen immunotherapy 1,25(OH)2D3 potentiates suppressive effects and immunoregulatory cytokines IL-10 TGF-β are involved effector phase. OVA-sensitized challenged BALB/c mice displayed airway hyperresponsiveness (AHR) serum...
Abstract: Background: Prebiotic galacto‐ and fructo‐oligosaccharides (sc GOS /lc FOS ) resembling non‐digestible oligosaccharides in human milk reduce the development of atopic disorders. However, underlying mechanisms are still unclear. Galectins soluble‐type lectins recognizing β‐galactoside containing glycans. Galectin‐9 has been shown to regulate mast cell degranulation T ‐cell differentiation. In this study, involvement galectin‐9 as a mechanism by which sc combination with...
Background and Aim: Endothelial activation is characterized by excessive production of cytokines chemokines as well adhesion molecules expression which involved in the development atherosclerosis. The aim our study to investigate effects short chain fatty acids (SCFA) on lipopolysaccharide (LPS) or tumor necrosis factor alpha (TNFα)-induced endothelial activation. Methods results: Human umbilical vein cells (HUVEC) were pre-treated with acetate (10mM), butyrate (0.1mM) propionate (0.3mM) for...
Eosinophilic esophagitis (EoE) is a food allergen driven disease that accompanied by interleukin (IL) 13 overexpression and esophageal barrier dysfunction allowing transepithelial permeation. Nutraceuticals, such as short-chain fatty acids (SCFAs) restore function increase immune fitness may be promising tool in the management of EoE. Here, we investigated effects SCFAs acetate, propionate, butyrate on an IL-13-compromised human epithelial barrier, including mechanisms involved.An air-liquid...
Hypoallergenic formulas are considered a good option for infants at risk cow's milk allergy. The aim of this animal study was to investigate whether whey hydrolyzates (WH) have the capacity induce oral tolerance whey.Whey, partial or extensive WH given via gavages naïve mice prior sensitization using cholera toxin as an adjuvant. acute allergic skin response, mouse mast cell protease-1 (mMCP-1), whey-specific IgE, IgG(1) and effector Th2-cells, Th1-cells, Foxp3(+) regulatory T-cells were...
Cow's milk allergy is one of the most common food allergies in children and no treatment available. Dietary lipid composition may affect susceptibility to develop allergic disease.Assess whether dietary supplementation with long chain n-3 polyunsaturated fatty acids (n-3 LCPUFA) prevents establishment allergy.Mice were fed a control or fish oil diet before during oral sensitization whey. Acute skin response, serum immunoglobulins as well dendritic cell (DC) T subsets mesenteric lymph nodes...
Abstract Background Prior exposure to partial whey hydrolysates has been shown reduce the allergic response in mice. This effect was more pronounced combination with a diet containing non‐digestible oligosaccharides (sc GOS /lc FOS / pAOS ). It is unknown which fractions/epitopes are responsible for this effect. Therefore, prophylactic ability of synthetic peptides β‐lactoglobulin with/without sc /p AOS ‐containing mouse model cow's milk allergy investigated. Methods Of 31 peptides, nine...
Several studies demonstrated the adverse effect of milk processing on allergy-protective capacity raw cow's milk. Whether also affects allergenicity is hardly investigated.To assess (unprocessed) and processed in a murine model for food allergy as well allergic children.C3H/HeOuJ mice were either sensitized to whole (raw milk, heated or shop [store-bought milk]) challenged with protein they whey proteins (native heated). Acute symptoms, mast cell degranulation, allergen-specific IgE levels...
Epidemiological studies show an inverse relation between raw cow's milk consumption and the development of asthma. This protective effect seems to be abolished by processing. However, evidence for a causal relationship is lacking, direct comparisons processed are hardly studied. Therefore, this study investigated preventive capacity heated on house dust mite (HDM)-induced allergic asthma in mice. Six- seven-week-old male BALB/c mice were intranasally (i.n.) sensitized with 1 µg HDM or PBS...
Barrier dysfunction of airway epithelium contributes to the development allergies, hyper-responsiveness and immunological respiratory diseases. Short-chain fatty acids (SCFA) enhance restore barrier function intestinal epithelium. This study investigated whether acetate, propionate butyrate integrity bronchial epithelial cells. Differentiating human cells (16HBE) grown on transwells were exposed butyrate, acetate while trans-epithelial electrical resistance was monitored over time....