A5050592396- Elbow and Forearm Trauma Treatment
- Orthopedic Surgery and Rehabilitation
- Emergency and Acute Care Studies
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Trauma and Emergency Care Studies
- Shoulder and Clavicle Injuries
- Airway Management and Intubation Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Bone fractures and treatments
- Child and Adolescent Health
- Sports injuries and prevention
- Pharmaceutical studies and practices
- Infant Development and Preterm Care
- Ethics and Legal Issues in Pediatric Healthcare
- Childhood Cancer Survivors' Quality of Life
- Anesthesia and Sedative Agents
- Respiratory Support and Mechanisms
- Poisoning and overdose treatments
- Streptococcal Infections and Treatments
- Health Sciences Research and Education
- Injury Epidemiology and Prevention
- Dental Trauma and Treatments
- Neonatal and fetal brain pathology
- Respiratory viral infections research
Alder Hey Children's NHS Foundation Trust
2014-2024
Alder Hey Children's Hospital
2014-2024
University of Liverpool
2014-2024
University of Oxford
2024
Nuffield Orthopaedic Centre
2024
University of Western Macedonia
2024
Children’s Foundation
2022
Merseytravel
2008
Phenytoin is the recommended second-line intravenous anticonvulsant for treatment of paediatric convulsive status epilepticus in UK; however, some evidence suggests that levetiracetam could be an effective and safer alternative. This trial compared efficacy safety phenytoin management epilepticus.This open-label, randomised clinical was undertaken at 30 UK emergency departments secondary tertiary care centres. Participants aged 6 months to under 18 years, with requiring treatment, were...
BackgroundThe most common fractures in children are torus (buckle) of the wrist. Controversy exists over treatment, which ranges from splint immobilisation and discharge to cast immobilisation, follow-up, repeat imaging. This study compared pain function affected offered a soft bandage immediate with those receiving rigid follow-up as per treating centre protocol.MethodsIn this randomised controlled equivalence trial we included 965 (aged 4–15 years) distal radius fracture 23 hospitals UK....
To inform the design of a randomised controlled trial (called EcLiPSE) to improve treatment children with convulsive status epilepticus (CSE). EcLiPSE requires use controversial deferred consent process.Qualitative interview and focus group study.8 UK support groups for parents who have chronic or acute health conditions experience paediatric emergency care.17 parents, whom 11 participated in telephone interviews (10 mothers, 1 father) 6 (5 father). (35%) were bereaved 7 (41%) had...
Background During the initial phase of Coronavirus Disease 2019 (COVID-19) pandemic, reduced numbers acutely ill or injured children presented to emergency departments (EDs). Concerns were raised about potential for delayed and more severe presentations an increase in diagnoses such as diabetic ketoacidosis mental health issues. This multinational observational study aimed number presenting EDs across Europe during early COVID-19 pandemic factors influencing this investigate changes severity...
Convulsive status epilepticus (CSE) is the most common life-threatening neurological emergency in childhood. These children are also at risk of significant morbidity, with acute and chronic impact on family health social care systems. The current recommended first-choice, second-line treatment aged 6 months above intravenous phenytoin (fosphenytoin USA), although there a lack evidence for its use it associated side effects. Emerging suggests that levetiracetam may be effective as agent CSE,...
Background Convulsive status epilepticus is the most common neurological emergency in children. Its management important to avoid or minimise morbidity and death. The current first-choice second-line drug phenytoin (Epanutin, Pfizer Inc., New York, NY, USA), for which there no robust scientific evidence. Objective To determine whether levetiracetam (Keppra, UCB Pharma, Brussels, Belgium) more clinically effective intravenous treatment of paediatric convulsive help better inform its...
Aims Torus fractures are the most common childhood fracture, accounting for 500,000 UK emergency attendances per year. treatment varies widely due to lack of scientific evidence. This is protocol a randomized controlled equivalence trial ‘the offer soft bandage and immediate discharge’ versus ‘rigid immobilization follow-up as treating centre’ in torus . Methods Children aged four 15-years-old inclusive who have sustained torus/buckle fracture distal radius with/without an injury ulna...
Objective To assess paediatric emergency department (PED) health professionals’ confidence, experience and awareness in managing traumatic dental injuries (TDIs). Design A cross-sectional online survey. Setting PED at Alder Hey Children’s Hospital Birmingham Hospital. Results 94 ED professionals responded. One-third of responders (n=26) encounter children with trauma daily or weekly. TDI teaching during undergraduate training was received by 13% (n=12) responders, 32% (n=30) had never...
This study sought to estimate the clinical outcomes and describe nationwide variation in practice, as part of feasibility workup for a National Institute Health Care Excellence (NICE) recommended randomized trial determine optimal treatment torus fractures distal radius children.Prospective data collection on presenting our emergency department. Patient consent information, including copy Wong-Baker Faces pain score, was issued at first patient contact. An automated text message service...
The aim of this trial was to assess the cost-effectiveness a soft bandage and immediate discharge, compared with rigid immobilization, in children aged four 15 years torus fracture distal radius.
Abstract Background Point-of-care testing (POCT) is diagnostic performed at or near to the site of patient. Understanding current capacity, and scope, POCT in this setting essential order respond new research evidence which may lead wide implementation. Methods A cross-sectional online survey study use was conducted between 6th January 2nd February 2020 on behalf two United Kingdom (UK) Ireland-based paediatric networks (Paediatric Emergency Research UK Ireland, General Adolescent Paediatric...
Background Torus (buckle) fractures of the wrist are most common in children involving distal radius and/or ulna. It is unclear if require rigid immobilisation and follow-up or would recover equally as well by being discharged without any a bandage. Given large number these injuries, identifying optimal treatment strategy could have important effects on child, days school absence NHS costs. Objectives To establish whether not treating with torus fracture offer soft bandage immediate...
EcLiPSE (Emergency treatment with Levetiracetam or Phenytoin in Status Epilepticus children) is a randomised controlled trial (RCT) the United Kingdom. Challenges to success include need immediately administer an intervention without informed consent and changes staffing during conduct, mainly due physician rotations. Using literature on parents' perspectives research prior (RWPC) guidance, we developed interactive training package (including videos, simulation question answer sessions)...
Dental attendances to paediatric emergency departments (PEDs) represent suboptimal use of resources an unknown scale.To evaluate dental at two PEDs in the UK and compare traumatic injury (TDI) non-traumatic conditions (NTDCs).Retrospective data were collected for a 12-month period including demographics, attendance pattern, assessment, management. Maxillofacial excluded, grouped as TDI NTDC.Of 667 attendances, 35.1% (n = 234) 64.9% 433) NTDC. Nineteen children reattended. Proportionately,...
Alternatives to prospective informed consent enable the conduct of paediatric emergency and critical care trials. Research without prior (RWPC) involves practitioners approaching parents after an intervention has been given seeking for their child continue in trial. As part embedded study 'Emergency treatment with Levetiracetam or Phenytoin Status Epilepticus children' (EcLiPSE) trial, we explored how described trial RWPC during recruitment discussions, well this information was understood...
Aims This study sought to estimate the clinical outcomes and describe nationwide variation in practice, as part of feasibility workup for a National Institute Health Care Excellence (NICE) recommended randomized trial determine optimal treatment torus fractures distal radius children. Methods Prospective data collection on presenting our emergency department. Patient consent information, including copy Wong-Baker Faces pain score, was issued at first patient contact. An automated text...
Key challenges to the successful conduct of The Emergency treatment with Levetiracetam or Phenytoin in Status Epilepticus children (EcLiPSE) trial were identified at pre-trial stage. These included practitioner anxieties about conducting research without prior consent (RWPC), inexperience an ED-led and use a medication that was not usual ED practice. As part embedded study, we explored parent experiences recruitment, RWPC inform design future trials.