A5102802333- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- COVID-19 and healthcare impacts
- Pancreatic and Hepatic Oncology Research
- Eosinophilic Esophagitis
- Neuroscience and Neural Engineering
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Neural dynamics and brain function
- stochastic dynamics and bifurcation
- Pancreatitis Pathology and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Lung Cancer Diagnosis and Treatment
- Appendicitis Diagnosis and Management
- Cancer Cells and Metastasis
- Gallbladder and Bile Duct Disorders
- Neurological disorders and treatments
- Bariatric Surgery and Outcomes
- Global Health and Surgery
- Helicobacter pylori-related gastroenterology studies
- Foreign Body Medical Cases
- Parkinson's Disease Mechanisms and Treatments
- Anorectal Disease Treatments and Outcomes
Croydon University Hospital
2022-2025
Queen Elizabeth Hospital Birmingham
2021-2024
Fluor (United States)
2024
Barking, Havering And Redbridge University Hospitals NHS Trust
2019-2023
Musgrove Park Hospital
2023
St Thomas' Hospital
2019-2022
Guy's and St Thomas' NHS Foundation Trust
2019-2022
Croydon Health Services NHS Trust
2022
King's College London
2021
Thomas Foundation
2020
Abstract Epithelial tissues have sparse stroma, in contrast to their corresponding tumours. The effect of cancer cells on stromal is well recognized. Increasingly, components, such as endothelial and immune cells, are considered indispensable for progression. role desmoplastic contrast, poorly understood. Targeting cellular components within the tumour attractive. Recent evidence strongly points towards a dynamic cell participation progression that impacts patient prognosis. specific...
Abstract Inspired by lotus leaves, self‐floating Janus cotton fabric is successfully fabricated for solar steam generation with salt‐rejecting property. The layer‐selective soot‐deposited fabrics not only act as a absorber but also provide the required superhydrophobicity floating on water. With polyester protector, prepared evaporator exhibits sustainable evaporation rate of 1.375 kW m −2 h −1 and an efficiency 86.3% under 1 sun (1 ) performs well low intensity inclined radiation....
Epidermal levels of enzymatic and non-enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), vitamin E (Vit E), ubiquinol (CoQ10H2), reduced (GSH), well polyunsaturated fatty acids phospholipids (PL-PUFA), were evaluated in the affected epidermis 15 patients with active vitiligo (AVP) corresponding healthy phototype matched controls. The epidermal CoQ10H2, Vit E, GSH, CAT activity significantly AVP associated a marked increase oxidized...
The vascular heterogeneity of pancreatic ductal adenocarcinoma (PDAC) has never been characterised. We analysed the heterogeneous density human PDAC along with its prognostic correlation. Tissue Microarrays 87 patients different pancreatico-biliary pathologies were in an automated manner (Ariol™) after CD31 staining to assess juxta-tumoral and panstromal compartments. In vitro ex vivo assays carried out role PSC. a distinct distribution vessels compared cholangiocarcinoma. stroma was...
Decision-making in emergency settings is inherently complex, requiring surgeons to rapidly evaluate various clinical, diagnostic, and environmental factors. The primary objective assess a patient's risk for adverse outcomes while balancing diagnoses, management strategies, available resources. Recently, indocyanine green (ICG) fluorescence imaging has emerged as valuable tool enhance surgical vision, demonstrating proven benefits elective surgeries. This consensus paper provides...
AbstractIt has been reported that iron overload in β-thalassemia leads to an enhanced generation of reactive oxygen species and oxidative stress. We have studied the oxidant/antioxidant imbalance blood 48 transfusion-dependent β-thalassemic patients (TLP) (17 males, 31 females, 11–22 year), under chelation therapy, 40 sex age matched healthy controls (CTR). Plasma lymphocyte levels vitamin E (Vit E), ubiquinol (CoQ10H2), ubiquinone (CoQ10), plasma concentrations A A), β-carotene, lycopene, C...
Abstract Pancreatic ductal adenocarcinoma (PDAC) treatments have historically focused on targeting tumor cells directly. However, in pancreatic masses, the stroma encasing malignant epithelial constitutes up to 80% 90% of bulk. This extracellular matrix, which was previously neglected when designing cancer therapies, is now considered fundamental for progression and drug delivery. Desmoplastic tissue extensively cross-linked, resulting tremendous tensile strength. key pathological feature...
Peroral endoscopic myotomy (POEM) is a safe and effective minimally invasive treatment for achalasia. Postoperative reflux rates remain high. The functional luminal imaging probe (FLIP) allows intraoperative measurement of lower esophageal distensibility during POEM. In theory, this enables tailoring myotomies to ensure adequate while minimizing postoperative risk. Two prospectively collected POEM databases were analyzed from two UK tertiary upper GI centers. operators in each center used...
<i>Aim:</i> To study whether microvascular leukocyte accumulation after rat renal ischemia and reperfusion (IR) is decreased by Rho kinase inhibition, independently of effects upon nitric oxide (NO) blood flow. <i>Methods:</i> Male Wistar rats were subjected to 60 min bilateral clamping the arteries, or a sham procedure. Haemodynamics monitored microsphere flow kidneys was measured. The infusion inhibitor (Y27632) commenced before IR. NO synthase inhibitor,...
Background. Emergency cholecystectomy is the gold standard treatment for acute cholecystitis according to National Institute Health and Care Excellence recommendations. The procedure feasible but carries a higher risk of iatrogenic injury bile duct, which should be considered preventable. Intraoperative fluorescence cholangiography following injection indocyanine green (ICG) has been reported aid identification extrahepatic duct. Data on its feasibility in context emergency cholecystectomies...
Deep Brain Stimulation (DBS) has revealed a convincing clinical efficacy in Parkinson's diseases and essential tremor. Unfortunately, to date no clear understanding of the therapeutic mechanisms been achieved. Characterization distribution electrical quantities inside target areas central nervous system is one fundamental step ahead. Starting from studies that so far addressed this issue, aim work quantify role some parameters, such as dimensions conducting domain boundary conditions, on...
Surgical consent is one of the pillars ethical conduct in Western world surgical practice. Recent studies have described consenting processes for clinical trials low- and middle-income countries (LMICs), but only a few explored its practice before procedures. The recent World Medical Association (WMA) Declaration Lisbon recommends autonomy independent decision-making. However, informed influenced by cultural background, family structure, socioeconomic status, religion education. authors...
Deep Brain Stimulation (DBS) is a clinically suitable technique for the treatment of Parkinson's disease. Recently, also other neurological disorders such as Tourette syndrome, obsessive-compulsive disorder, epilepsy are being to be treated with DBS. However, debate on its therapeutic mechanisms action still open. In order better understanding mechanisms, in this work attention focused DBS micro-stimulation. Indeed, micro electrodes registration and stimulation fundamental step, during...
Neuronal networks with feedforward architecture are typical of peripheral nervous system. A realistic stochastic model network was here implemented and used to investigate the sensitivity neuronal sensory pathways input electromagnetic (EM) fields. Aim this work address characterize EM signal detectability throughout network, pointing out biophysical properties underlying possible amplification. Synaptic noise is shown enhance transduction according resonance paradigm, pooling neuron...
Endogenous noise has been shown to play a central role in the detection of an electromagnetic signal nervous system. In this work, following biomedical perspective, exogenous applied realistic feedforward network model considered. It will be that, if is properly filtered and its level adjusted, clear optimization encoding signal, representative external stimulation, obtained through stochastic resonance paradigm.
Deep brain stimulation is a technique clinically successful for movement disorders including Parkinson's disease and essential tremor. Moreover, its possible application to treatment of epilepsy obsessive-compulsive becoming real perspective. Besides convincing clinical efficacy, date no clear understanding the therapeutic mechanisms achieved. In order obtain an in depth knowledge action this technique, paper 3D electromagnetic model anatomical region involved electrical has been developed....
A number of experimental investigations have evidenced the extraordinary sensitivity neuronal cells to weak input stimulations, including electromagnetic (EM) fields. Moreover, it has been shown that biological noise, due random channels gating, acts as a tuning factor in processing, according stochastic resonant (SR) paradigm. In this work attention is focused on noise arising from gating ionic model Ranvier node acoustic fibers. The small gives rise high level, which able cause spike train...
Prostate cancer is a leading cause of death in men and despite improved surgical procedures that aid tumor resection, the risk recurrence after surgery as result positive resection margins remains significant. Adjuvant chemotherapy often required but this associated with toxicity. Improved ways delivering highly toxic chemotherapeutic drugs more controlled targeted manner prostate has been removed during could reduce avoid systemic The aim study was to develop novel drug-device combination...
: Laparoscopic paraesophageal hernia (PEH) repair can be performed safely in expert hands. However, it is a complex operation carrying significant risk of peri-operative morbidity and mortality. Careful intra-operative correctional techniques prompt return to theatre for early post-operative complications result satisfactory outcome. Capnothorax pneumothorax should dealt with immediately by lowering insufflation pressure, aspiration drain placement. Hemodynamic instability from...