A5008840358- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Aortic aneurysm repair treatments
- COVID-19 and healthcare impacts
- Cancer Research and Treatments
- Appendicitis Diagnosis and Management
- Abdominal vascular conditions and treatments
- Aortic Disease and Treatment Approaches
- Vascular Procedures and Complications
- Cancer-related Molecular Pathways
- Esophageal and GI Pathology
- Ubiquitin and proteasome pathways
- Nerve Injury and Rehabilitation
- Infectious Aortic and Vascular Conditions
- Foreign Body Medical Cases
- Spine and Intervertebral Disc Pathology
- Multiple and Secondary Primary Cancers
- Hemostasis and retained surgical items
- Gastric Cancer Management and Outcomes
- Intestinal Malrotation and Obstruction Disorders
- Metastasis and carcinoma case studies
- Abdominal Surgery and Complications
- Cervical and Thoracic Myelopathy
- Genetic factors in colorectal cancer
St Thomas' Hospital
2021-2024
Collaborative Group (United States)
2023
Guy's and St Thomas' NHS Foundation Trust
2017-2023
University Hospitals Coventry and Warwickshire NHS Trust
2023
University Hospitals of Leicester NHS Trust
2023
Salisbury NHS Foundation Trust
2023
Salisbury University
2023
National Health Service
2022
University of Mississippi
2017
West Bengal State University
2017
Methionine adenosyltransferase 2B (MAT2B) encodes for two variant proteins (V1 and V2) that promote cell growth. Using in-solution proteomics, GIT1 (G Protein Coupled Receptor Kinase Interacting ArfGAP 1) was identified as a potential interacting partner of MAT2B. Here, we examined the functional significance this interplay. Coimmunoprecipitation experiments protein interactions. Tissue expression levels were using immunohistochemistry western blotting. Expression varied transient knockdown...
Ubiquitin-conjugating enzyme 9 (Ubc9) is required for sumoylation and overexpressed in several malignancies, but its expression hepatocellular carcinoma (HCC) unknown. Hepatic S-adenosyl methionine (SAMe) levels decrease adenosyltransferase 1A (Mat1a) knockout (KO) mice, which develop HCC, ethanol-fed mice. We examined the regulation of Ubc9 by SAMe murine liver human breast, colon cell lines specimens. Real-time polymerase chain reaction western blotting measured gene protein expression,...
Transanal haemorrhoidal dearterialization (THD) has become well established for the treatment of haemorrhoids. In this study we describe a technical modification technique, targeted mucopexy (THD TM), and report results advanced haemorrhoids.The included prospective evaluation patients with Grade IV (fourth-degree) haemorrhoids operated on THD TM technique. This consisted an initial when arteries were transfixed second phase mucopexy, using different needle from that usually used in original...
// Maria Lauda Tomasi 1, 2 , Minjung Ryoo Komal Ramani Ivan 3 Pasquale Giordano 4 José M. Mato 5 Shelly C. Lu 1 Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA USC Research Center for Liver Diseases, Keck School Medicine University Southern California, 90033, General Surgery Department, Rotherham Hospital, S60 2UD, UK Colorectal Barts Health, London E11 1NR, CIC bioGUNE, Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas...
The authors illustrate their results in the surgical treatment of symptomatic thoracic disc herniations (TDHs) by comparing traditional open to less invasive retropleural lateral approaches.Retrospective review 94 consecutive cases treated at a single Institution between 1988 and 2014. Fifty-two patients were males, 42 females, mean age was 53.9 years. Mean follow-up 46.9 months (12-79 months). 33 diagnosed with giant herniation (GTDH). Upon admission, most common symptoms were: motor...
Abstract Aim Ventral hernia (VH) is a common condition in general surgery. Management conservative or surgical (either electively emergently). Approximately 10% require emergency surgery, which associated with higher rates of post-operative complications and mortality. This retrospective audit aims to compare performances VH management at tertiary hospital London over the last 7 years against 2017 WSES. The study focuses on timing surgery after admissions, co-morbidities, size defect,...
Heterotopic pancreas (HP) is defined as the presence of pancreatic tissue without anatomical and vascular continuity with main body pancreas. HP typically remains asymptomatic, however complications such acute pancreatitis can arise. Gastrointestinal involvement coronavirus disease 2019 (COVID-19) not uncommon there are reported cases associated pancreatitis.A 31-year-old male presented to Emergency department (ED) a 3-day history right iliac fossa pain. The patient was found have COVID-19...
Acute appendicitis (AA) is predominantly managed with appendectomy, but can be treated non-operatively, leading to a high risk of recurrence. Non-operative management has been more common since the COVID-19 pandemic affected feasibility performing surgery. This case-control study analyzed non-operatively patients in order identify clinical and radiological factors associated recurrence risk. Methods: Over 12 months, 48 adults CT-proven AA were identified, followed up for at least six further...
Abstract Background A biliary quality improvement project (QuIP) was established in 2019 following 3 audit cycles highlighting delays to laparoscopic cholecystectomy (Lap-C) patients with gallstone pancreatitis. Limited theatre space and prioritisation of high volume cancer work hindered previous efforts improve the service between 2015 2019. The latest phase QuIP has introduced a dedicated consultant lead service, live admission tracking system, increased in-patient Lap-C, implementation...
Abstract Aim The GI surgery department deals with many clinical conditions including lumps and bumps that affect the torso, posterior neck, groin, buttock, perianal perineal areas. Over pandemic it was noted there were referrals for ‘lumps bumps’ at a time where theatre capacity staffing limited. To create referral pathway to assess patients suitability treatment in secondary care setting/ determine which lesions suitable community. Method A review of 374 cases referred between 2019 2021....
Abstract Background A biliary quality improvement project (QuIP) was established in 2019 following 3 audit cycles highlighting delays to laparoscopic cholecystectomy (Lap-C) patients with gallstone pancreatitis. Limited theatre space and other urgent care priorities hindered efforts meet key performance indicator targets between 2015 2019. The last phase of the QuIP has introduced a dedicated consultant lead service, live patient tracking system, increased in-patient Lap-C, implementation...
The clinicopathological profile of lung adenocarcinoma (LAC) differs in smokers and non-smokers.LAC is relatively resistant to therapies.For example, targeted therapeutic agents like EGFR-inhibitors (erlotinib gefitinib) are highly effective LACs which develop nonsmokers.However, such therapies display much lower anti-tumor activity patients who active smokers.Similarly, cancer (who smokers) show a response chemotherapy than those non-smokers.However, the majority LAC smokers.This underlines...
Abstract Background/Objective Acute appendicitis is predominantly managed with appendectomy, but can be treated non-operatively, leading to recurrence risk. Non-operative management has been more common since the COVID-19 pandemic affected feasibility of performing surgery. This case-control study analyzed non-operatively patients in order identify clinical and radiological factors associated Methods Over 12 months, 48 adults CT-proven acute were identified, followed up for at least 6...