A5021779917- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Autoimmune and Inflammatory Disorders Research
- Eosinophilic Esophagitis
University of Cincinnati Medical Center
2023
Ohio Supercomputer Center
2021
The Ohio State University
2020
Group 1 innate lymphoid cells (ILCs) comprise a heterogeneous family of cytotoxic natural killer (NK) and ILC1s. We identify population "liver-type" ILC1s with transcriptional, phenotypic, functional features distinct from those conventional liver-resident NK as well other previously described human ILC1 subsets. LT-ILC1s are CD49a+CD94+CD200R1+, express the transcription factor T-BET, do not activating receptor NKp80 or EOMES. Similar to cells, liver-type produce IFN-γ, TNF-α, GM-CSF;...
Human NK cells develop in tonsils through discrete cell developmental intermediates (NKDIs), yet the mechanistic regulation of this process is unclear. We demonstrate that Notch activation human tonsil-derived stage 3 (CD34-CD117+CD94-NKp80-) and 4A (CD34-CD117+/-CD94+NKp80-) NKDIs promoted non-NK innate lymphoid differentiation at expense differentiation. In contrast, 4B (CD34-CD117+/-CD94+NKp80+) were lineage committed despite activation. Interestingly, whereas functional maturation from...