A5102883546- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Eosinophilic Esophagitis
- Elbow and Forearm Trauma Treatment
- Immunotherapy and Immune Responses
- Lung Cancer Diagnosis and Treatment
- Immune cells in cancer
- Tendon Structure and Treatment
- Colorectal Cancer Surgical Treatments
- HIV Research and Treatment
- Advanced MRI Techniques and Applications
- Health and Medical Research Impacts
- Orthopedic Surgery and Rehabilitation
- Parasitic Diseases Research and Treatment
- Immune Response and Inflammation
- Advanced Radiotherapy Techniques
- Vitamin D Research Studies
- MRI in cancer diagnosis
- Gastric Cancer Management and Outcomes
- Metabolomics and Mass Spectrometry Studies
- Colorectal and Anal Carcinomas
- Psoriasis: Treatment and Pathogenesis
- Hepatocellular Carcinoma Treatment and Prognosis
Krankenhaus Barmherzige Brüder
2023
University of Bonn
2016-2022
University Hospital Bonn
2016-2022
Massachusetts General Hospital
2017
Harvard University
2017
Athinoula A. Martinos Center for Biomedical Imaging
2017
University of Würzburg
2017
RWTH Aachen University
2013-2016
Universitätsklinikum Aachen
2015
Universitätsklinikum Würzburg
2015
Innate lymphoid cells (ILC) play an important role in many immune processes, including control of infections, inflammation, and tissue repair. To date, little is known about the metabolism ILC whether these can metabolically adapt response to environmental signals. Here we show that type 2 innate (ILC2), mediators barrier immunity, predominantly depend on fatty acid (FA) during helminth infection. Further, situations where essential nutrient, such as vitamin A, limited, ILC2 sustain their...
Compared to the innate immune system, contribution of adaptive response during obesity and insulin resistance is still not completely understood. Here we demonstrate that high fat diet (HFD) increases frequencies activated CD4+ CD8+ T cells positive for IFN-γ IL-17 in adipose tissue. The adipocyte-derived soluble factor adiponectin reduces from HFD mice dampens differentiation naïve into Th1 Th17 cells. Adiponectin cell restrains glycolysis an AMPK dependent fashion. Treatment with adult...
Human immunodeficiency virus (HIV) infection is associated with impaired natural killer (NK) cell activity, which only incompletely restored under antiretroviral therapy. Analyzing the bioenergetics profiles of oxygen consumption, we observed that several parameters were significantly reduced in HIV+ NK cells, indicating a mitochondrial defect. Accordingly, found CD56bright cells to display decreased membrane potential and mass. Both positively correlated interferon gamma (IFN-γ) production...