Adam J. Kundishora
A5064024426- Cerebrospinal fluid and hydrocephalus
- Fetal and Pediatric Neurological Disorders
- Glioma Diagnosis and Treatment
- Scoliosis diagnosis and treatment
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Head and Neck Surgical Oncology
- Neurosurgical Procedures and Complications
- Pelvic and Acetabular Injuries
- Spinal Dysraphism and Malformations
- Traumatic Brain Injury and Neurovascular Disturbances
- Cervical and Thoracic Myelopathy
- Intracerebral and Subarachnoid Hemorrhage Research
- Brain Metastases and Treatment
- Neurological disorders and treatments
- Meningioma and schwannoma management
- Epilepsy research and treatment
- Genomics and Rare Diseases
- Genetic and Kidney Cyst Diseases
- EEG and Brain-Computer Interfaces
- Intracranial Aneurysms: Treatment and Complications
- Pituitary Gland Disorders and Treatments
- Neuroblastoma Research and Treatments
- Vascular Malformations Diagnosis and Treatment
- Hip disorders and treatments
Children's Hospital of Philadelphia
2024-2025
Yale University
2017-2023
The University of Texas Health Science Center at Houston
2021
Stony Brook University
2020
Neurological Surgery
2020
Kanazawa University
2020
Oxford University Press (United Kingdom)
2020
Impaired breathing, cardiac function, and arousal during after seizures are important causes of morbidity mortality. Previous work suggests that these changes associated with depressed brainstem function in the ictal post-ictal periods. Lower serotonergic systems postulated to play an role cardiorespiratory seizures, whereas upper other regulate arousal. However, direct demonstration seizure-associated neuronal activity regions has been lacking. Here, we performed multiunit single-unit...
Absence seizures are brief episodes of impaired consciousness, behavioral arrest, and unresponsiveness, with yet-unknown neuronal mechanisms. Here we report that an awake female rat model recapitulates the behavioral, electroencephalographic, cortical functional magnetic resonance imaging characteristics human absence seizures. Neuronally, feature overall decreased but rhythmic firing neurons in cortex thalamus. Individual thalamic express one four distinct patterns seizure-associated...
Impaired consciousness occurs suddenly and unpredictably in people with epilepsy, markedly worsening quality of life increasing risk mortality. Focal seizures impaired are the most common form epilepsy refractory to all current medical surgical therapies about one-sixth cases. Restoring during following would be potentially transformative for these individuals. Here, we investigate deep brain stimulation improve level conscious arousal a rat model focal limbic seizures. We found that...
<h3>Importance</h3> Moyamoya disease (MMD), a progressive vasculopathy leading to narrowing and ultimate occlusion of the intracranial internal carotid arteries, is cause childhood stroke. The MMD poorly understood, but genetic factors play role. Several familial forms have been identified, most cases remains elusive, especially among non–East Asian individuals. <h3>Objective</h3> To assess whether ultrarare de novo rare, damaging transmitted variants with large effect sizes are associated...
Trigeminal neuralgia (TN) is a common, debilitating neuropathic face pain syndrome often resistant to therapy. The familial clustering of TN cases suggests that genetic factors play role in disease pathogenesis. However, no unbiased, large-scale genomic study has been performed date. Analysis 290 whole exome-sequenced probands, including 20 multiplex kindreds and 70 parent-offspring trios, revealed enrichment rare, damaging variants GABA receptor-binding genes cases. Mice engineered with...
Abstract Pediatric hydrocephalus, the leading reason for brain surgery in children, is characterized by enlargement of cerebral ventricles classically attributed to cerebrospinal fluid (CSF) overaccumulation. Neurosurgical shunting reduce CSF volume default treatment that intends reinstate normal homeostasis, yet neurodevelopmental disability often persists hydrocephalic children despite optimal surgical management. Here, we discuss recent human genetic and animal model studies are shifting...
Abstract To elucidate the pathogenesis of vein Galen malformations (VOGMs), most common and severe congenital brain arteriovenous malformations, we performed an integrated analysis 310 VOGM proband-family exomes 336,326 human cerebrovasculature single-cell transcriptomes. We found Ras suppressor p120 RasGAP ( RASA1 ) harbored a genome-wide significant burden loss-of-function de novo variants (2042.5-fold, p = 4.79 x 10 −7 ). Rare, damaging transmitted were enriched in Ephrin receptor-B4...
INTRODUCTION: Caring for patients with a terminal prognosis after non-survivable head injury is fraught ethical and moral challenges. METHODS: A web-based, 25-question survey was distributed to fifty academic hospitals. Conventional descriptive statistics inferential analyses were employed. RESULTS: 133 physicians completed the (29% neurosurgery, 25% trauma surgery, 45% critical care). Medical literacy (25%), patient religious/moral views (23%) trust (17%) identified as most significant...
INTRODUCTION: The factors associated with prolonged hospitalization following surgical release of tethered spinal cord in pediatric patients are relatively unknown. METHODS: A retrospective cohort study was performed using the 2012-2021 ACS NSQIP-Pediatric database. Patients undergoing laminectomy a were identified CPT and ICD-9/10 codes. dichotomized into two cohorts based on whether they experienced an extended postoperative hospital LOS, defined as LOS greater than 75th percentile for...
INTRODUCTION: Chiari malformation type 1 (CM1) is the most common disorder of craniocervical junction characterized by herniation cerebellar tonsils causing compression neural tissue and obstruction CSF flow. Despite its prevalence, our poor understanding molecular pathogenesis has contributed to significant variability in clinical surgical outcomes. METHODS: We performed WES 1585 patient-parent trios identify de novo variants (DNVs) uncover exome-wide high-confidence CM1 genes. Integrative...
Mounting evidence supports the presence of heterogeneity in presentation ependymoma patients with respect to location, histopathology, and behavior between pediatric adult patients. However, influence age on treatment outcomes remains obscure.The SEER database years 1975-2016 were queried. Patients a diagnosis identified using International Classification Diseases for Oncology, Third Edition, coding system. classified into one 4 groups: children (age 0-12 years), adolescents 13-21 young...
The postictal state following seizures is characterized by impaired consciousness and has a major negative impact on individuals with epilepsy. Previous work in disorders of including the suggests that bilateral deep brain stimulation (DBS) thalamic intralaminar central lateral nucleus (CL) may improve level arousal. We tested effects CL DBS rat model secondarily generalized elicited electrical hippocampal stimulation. Thalamic was delivered at 100 Hz during period 21 female rats while...
Health policy changes have led to increased emphasis on value-based care improve resource utilization and reduce inpatient hospital length of stay (LOS). Recently, LOS has become a major determinant quality utilization. For adolescent idiopathic scoliosis (AIS), the determinants extended after elective posterior spinal fusion (PSF) remain relatively unknown. In present study, authors investigated impact patient hospital-level risk factors following PSF surgery (≥ 4 levels) for AIS.
Congenital hydrocephalus (CH), characterized by incomplete clearance of CSF and subsequent enlargement brain ventricles, is the most common congenital disorder. The lack curative strategies for CH reflects a poor understanding underlying pathogenesis. Herein, authors present an overview recent findings in pathogenesis from human genetic studies discuss implications these treatment CH. Findings omics data have potential to reclassify according molecular nomenclature that may increase...