A5077591662- Glioma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Mathematical Biology Tumor Growth
- Neurosurgical Procedures and Complications
- Single-cell and spatial transcriptomics
- Traumatic Brain Injury and Neurovascular Disturbances
- Cell Image Analysis Techniques
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Meningioma and schwannoma management
- Vascular Malformations Diagnosis and Treatment
- Neurological Complications and Syndromes
- Cancer Genomics and Diagnostics
- Vasculitis and related conditions
- Head and Neck Surgical Oncology
- Renal and Vascular Pathologies
- Aortic aneurysm repair treatments
- Mitochondrial Function and Pathology
- Sinusitis and nasal conditions
- Sex and Gender in Healthcare
- Neural dynamics and brain function
- Disaster Response and Management
- Congenital gastrointestinal and neural anomalies
University of Pennsylvania
2024-2025
Mayo Clinic Hospital
2022-2024
University of Pennsylvania Health System
2024
Mayo Clinic in Arizona
2016-2023
Barrow Neurological Institute
2023
Mayo Clinic in Florida
2019-2023
Neurological Surgery
2021-2023
Hospital of the University of Pennsylvania
2023
WinnMed
2017-2023
Phoenix (United States)
2022-2023
<h3>BACKGROUND AND PURPOSE:</h3> Takayasu arteritis is a rare, large-vessel vasculitis that presents with symptoms related to end-organ ischemia. While the extracranial neurovascular manifestations of are well-established, little known regarding intracranial manifestations. In this study, we characterize and cervical radiologic findings in patients arteritis. <h3>MATERIALS METHODS:</h3> Patients who presented our institution between 2001 2016 and/or vascular imaging were included study....
INTRODUCTION: Caring for patients with a terminal prognosis after non-survivable head injury is fraught ethical and moral challenges. METHODS: A web-based, 25-question survey was distributed to fifty academic hospitals. Conventional descriptive statistics inferential analyses were employed. RESULTS: 133 physicians completed the (29% neurosurgery, 25% trauma surgery, 45% critical care). Medical literacy (25%), patient religious/moral views (23%) trust (17%) identified as most significant...
Abstract Background Myelomeningocele (MMC) and myeloschisis (MS) are severe neural tube defects that result in neurodevelopmental impairments hydrocephalus due to prenatal spinal cord exposure amniotic fluid. Fetal MMC/MS (fMMC/MS) repair has become the standard of care appropriately selected patients, demonstrating improved outcomes, including a reduction need for cerebrospinal fluid (CSF) diversion compared postnatal (pMMC/MS) closure. This study is detailed analysis incidence, timing,...
Abstract Lacunarity, a quantitative morphological measure of how shapes fill space, and fractal dimension, the complexity pixel arrangement, have shown relationships with outcome across variety cancers. However, application these metrics to glioblastoma (GBM), very aggressive primary brain tumor, has not been fully explored. In this project, we computed lacunarity dimension values for GBM-induced abnormalities on clinically standard magnetic resonance imaging (MRI). our patient cohort (n =...
Abstract Glioblastomas (GBMs) are biologically heterogeneous within and between patients. Many previous attempts to characterize this heterogeneity have classified tumors according their omics similarities. These discrete classifications predominantly focused on characterizing malignant cells, neglecting the immune other cell populations that known be present. We leverage a manifold learning algorithm define low-dimensional transcriptional continuum along which GBM samples organize. This...
Brain cancers pose a novel set of difficulties due to the limited accessibility human brain tumor tissue. For this reason, clinical decision-making relies heavily on MR imaging interpretation, yet mapping between MRI features and underlying biology remains ambiguous. Standard (clinical) tissue sampling fails capture full heterogeneity disease. Biopsies are required obtain pathological diagnosis predominantly taken from core, which often has different traits surrounding invasive that...
Abstract Brain cancers pose a novel set of difficulties due to the limited accessibility human brain tumor tissue. For this reason, clinical decision-making relies heavily on MR imaging interpretation, yet mapping between MRI features and underlying biology remains ambiguous. Standard (clinical) tissue sampling fails capture full heterogeneity disease. Biopsies are required obtain pathological diagnosis predominantly taken from core, which often has different traits surrounding invasive that...
OBJECTIVE Among patients with a history of prior lipomyelomeningocele repair, an association between increased lumbosacral angle (LSA) and cord retethering has been described. The authors sought to build predictive algorithm determine which complex tethered will develop the symptoms spinal after initial surgical repair focus on spinopelvic parameters. METHODS An electronic medical record database was reviewed identify (e.g., lipomyelomeningocele, lipomyeloschisis, myelocystocele) who...
Traumatic brain injury (TBI) remains a pervasive clinical problem associated with significant morbidity and mortality. However, TBI clinically biophysically ill-defined, prognosis difficult even the standardization of guidelines advent multimodality monitoring. Here we leverage unique data set from patients implanted either intracranial strip electrodes during craniotomy or quad-lumen bolts depth as part routine practice. By extracting spectral profiles this data, found that presence...
Abstract The intra- and inter-patient heterogeneity in high-grade glioma (HGG) continues to contribute its poor prognosis. Clinical biopsies are often harvested from limited regions typically not image localized. Thus, they fail capture the diversity within tumor regions, immune expression or normal cell abundances that play key roles development. It is important gain an understanding of these subpopulation ecologies, their spatial resolution, interactions between them may then be exploited...
Imaging is central to the clinical surveillance of brain tumors yet it provides limited insight into a tumor’s underlying biology. Machine learning and other mathematical modeling approaches can leverage paired magnetic resonance images image-localized tissue samples predict almost any characteristic tumor. Image-based takes advantage spatial resolution routine scans be applied measure biological differences within tumor, changes over time, as well variance between patients. This approach...
Abstract Purpose Accurate assessments of patient response to therapy are a critical component personalized medicine. In glioblastoma multiforme (GBM), the most aggressive form brain cancer, tumor growth dynamics heterogenous across patients, complicating assessment treatment response. This study aimed analyze Days Gained (DG), burgeoning model-based dynamic metric, for in patients with recurrent GBM who received bevacizumab-based therapies. Experimental Design scores were calculated using...
Abstract Background Accurate assessments of patient response to therapy are a critical component personalized medicine. In glioblastoma (GBM), the most aggressive form brain cancer, tumor growth dynamics heterogenous across patients, complicating assessment treatment response. This study aimed analyze days gained (DG), burgeoning model-based dynamic metric, for in patients with recurrent GBM who received bevacizumab-based therapies. Methods DG scores were calculated using volumetric...
Objective: To educate neurologists about a highly efficacious, minimally-invasive treatment for chronic subdural hematoma. Background: Chronic hematoma (cSDH) arises from injury to dural border cells. This initiates self-perpetuating inflammatory response complicated by the formation of vascularized neo-membranes that are fed middle meningeal artery (MMA). Blood and fluid extravasation through fragile arterial vessels fill new membrane-bound space. cSDH presents clinically in myriad forms...
Abstract Brain tumor associated edema is a significant cause of patient morbidity and mortality often requiring continual treatment with differing levels success across patients. Edema broad term that can indicate increased local water as well diffusely infiltrating cells. visualized hyperintense regions on T2-weighted (T2W) magnetic resonance imaging (MRI) typically blood-brain barrier (BBB) breakdown aggressiveness. Understanding the molecular mechanisms driving patterns “edema” could...