A5046351589- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury Research
- S100 Proteins and Annexins
- Trauma and Emergency Care Studies
- Cerebrovascular and Carotid Artery Diseases
- Neurosurgical Procedures and Complications
- Intensive Care Unit Cognitive Disorders
- Spinal Fractures and Fixation Techniques
- Sepsis Diagnosis and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cerebrospinal fluid and hydrocephalus
- Ion Transport and Channel Regulation
- Spinal Dysraphism and Malformations
- Stroke Rehabilitation and Recovery
- Neuroinflammation and Neurodegeneration Mechanisms
- Spine and Intervertebral Disc Pathology
- Neurogenesis and neuroplasticity mechanisms
- Neurological Complications and Syndromes
- Pain Management and Opioid Use
- Neonatal Respiratory Health Research
- Management of metastatic bone disease
St. Joseph's Hospital and Medical Center
2021-2025
Barrow Neurological Institute
2020-2024
University of Pittsburgh
2016-2024
Neurological Surgery
2017-2024
College Track
2022-2023
Yale University
2023
Biogen (United States)
2022
University Physicians
2018-2021
Baptist Hospital of Miami
2021
Children's Hospital of Pittsburgh
2017-2020
Traumatic brain injury (TBI) affects millions of people in the US each year. Most patients with TBI seen emergency departments (EDs) have a Glasgow Coma Scale (GCS) score 15 and head computed tomography (CT) scan showing no acute intracranial traumatic (negative CT scan), yet short-term long-term functional outcomes this subset remain unclear.To describe 2-week 6-month recovery cohort mild GCS negative scan.This study analyzed participants who were enrolled from January 1, 2014, to December...
The relationship between systemic inflammation and secondary injury in traumatic brain (TBI) is complex. We investigated associations inflammatory markers clinical confirmation of TBI diagnosis prognosis. prospective TRACK-TBI Pilot (Transforming Research Clinical Knowledge Traumatic Brain Injury Pilot) study enrolled patients triaged to head computed tomography (CT) received blood draw within 24 h injury. Healthy controls (HCs) orthopedic (OCs) were included. Thirty-one analyzed from...
Brain swelling causes morbidity and mortality in various brain injuries diseases but lacks effective treatments. is linked to the influx of water into perivascular astrocytes through channels called aquaporins. Water accumulation increases their volume, which contributes swelling. Using a mouse model severe ischemic stroke, we identified potentially targetable mechanism that promoted cell surface localization aquaporin 4 (AQP4) astrocytic endfeet, completely ensheathe brain’s capillaries....
Traumatic brain injury (TBI) heterogeneity remains a critical barrier to translating therapies. Identifying final common pathways/molecular signatures that integrate this informs biomarker and therapeutic-target development. We present the first large-scale murine single-cell atlas of transcriptomic response TBI (334,376 cells) across clinically relevant models, sex, region, time as foundational step in molecularly deconstructing heterogeneity. Results were unique cell populations, regions,...
<h3>Importance</h3> Mild traumatic brain injury (mTBI) may impair the ability to work. Strategies facilitate return work are understudied. <h3>Objective</h3> To assess employment and economic outcomes for employed, working-age adults with mTBI in 12 months after association between employer assistance. <h3>Design, Setting, Participants</h3> Using data from Transforming Research Clinical Knowledge Traumatic Brain Injury (TRACK-TBI) study, a cohort study of patients presenting emergency...
Despite the reported high prevalence of osteoporosis in India, there have been no previous studies examining risk factors for hip fracture Indian population.We carried out a case control investigation comprising 100 subjects (57 women and 43 men) admitted with first into one three hospitals across New Delhi. The controls were age sex matched who either healthy visitors not related to patients or hospital staff. Information from all was obtained through questionnaire based interview.There...
Intracranial pressure in traumatic brain injury is dynamic and influenced by factors like patterns, treatments, genetics. Existing studies use time invariant summary intracranial measures thus potentially losing critical information about temporal trends. We identified longitudinal trajectories severe evaluated whether they predicted outcome. further interrogated the model to explore ABCC8 polymorphisms (a known cerebraledema regulator) differed across trajectory groups.
Matrix metalloproteinase-9 (MMP-9) is elevated in patients with acute stroke who later develop hemorrhagic transformation (HT). It controversial whether early fluid-attenuated inversion recovery (FLAIR) hyperintensity on brain MRI predicts We assessed FLAIR was associated MMP-9 and HT. analyzed a prospectively collected cohort of subjects images values within the first 12 hours after onset. measured using signal intensity ratio between lesion corresponding normal contralateral hemisphere....
Cerebral edema is a key poor prognosticator in traumatic brain injury. There are no biomarkers identifying patients at-risk, or guiding mechanistically-precise therapies. Sulfonylurea receptor-1-transient receptor potential cation channel M4 upregulated only after injury, causing animal studies. We hypothesized that sulfonylurea receptor-1 measurable human cerebrospinal fluid severe injury and an informative biomarker of outcome.A total 119 samples were collected from 28 patients. Samples...
Posterior reversible encephalopathy syndrome is a multifactorial neurological disorder characterized by clinical and neuroimaging findings. The “vasogenic theory” suggests that, in this condition, disrupted cerebrovascular autoregulation leads to blood‐brain barrier failure vasogenic edema. commonly associated with hypertension, chemotherapy, transplantation, but neurosurgical patients, including those undergoing digital subtraction angiography, are also at elevated risk. A patient history...
INTRODUCTION: Thromboelastography (TEG) is a routine, relatively inexpensive blood test that measures the coagulative properties of sample. Previous studies have demonstrated its efficacy in predicting coagulation profiles patients with subarachnoid hemorrhage (SAH), however, relationship to neurological presentation and clinical outcome aneurysmal (aSAH) remains understudied. METHODS: We retrospectively identified 139 from July 2020 - September 2022 aSAH obtained TEGs without platelet...
Cerebral edema is critical to morbidity/mortality in traumatic brain injury (TBI) and worsened by hypotension. Glibenclamide may reduce cerebral inhibiting sulfonylurea receptor-1 (Sur1); its effect on diffuse exacerbated hypotension/resuscitation unknown. We aimed determine if glibenclamide improves pericontusional and/or controlled cortical impact (CCI) (5m/sec, 1 mm depth) plus hemorrhagic shock (HS) (35 min), compare effects CCI alone. C57BL/6 mice were divided into five groups (n =...
Objective ABCC8 encodes sulfonylurea receptor 1, a key regulatory protein of cerebral oedema in many neurological disorders including traumatic brain injury (TBI). Sulfonylurea-receptor-1 inhibition has been promising ameliorating clinical trials. We evaluated whether tag single-nucleotide polymorphisms predicted and outcome TBI. Methods DNA was extracted from 485 prospectively enrolled patients with severe 410 were analysed after quality control. (SNPs) identified (Hapmap, r 2 >0.8,...
Sulfonylurea-receptor-1(SUR1) and its associated transient-receptor-potential cation channel subfamily-M (TRPM4) are key contributors to cerebral edema intracranial hypertension in traumatic brain injury (TBI) other neurological disorders. Channel inhibition by glyburide is clinically promising. ABCC8 (encoding SUR1) single-nucleotide polymorphisms (SNPs) reported as predictors of raised pressure (ICP). This project evaluated whether TRPM4 SNPs predicted ICP TBI outcome. DNA was extracted...