A5031391323- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Bacterial Genetics and Biotechnology
- Genomics and Chromatin Dynamics
- Bacteriophages and microbial interactions
- Machine Learning in Bioinformatics
- Enzyme Production and Characterization
- vaccines and immunoinformatics approaches
- Adipokines, Inflammation, and Metabolic Diseases
- Enzyme-mediated dye degradation
- Monoclonal and Polyclonal Antibodies Research
- Biofuel production and bioconversion
- HIV Research and Treatment
- DNA and Nucleic Acid Chemistry
- Vibrio bacteria research studies
- Microbial Metabolism and Applications
- Transgenic Plants and Applications
- Adipose Tissue and Metabolism
- Plant-Microbe Interactions and Immunity
- DNA Repair Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Aquaculture disease management and microbiota
- Plant Pathogenic Bacteria Studies
- Protein Hydrolysis and Bioactive Peptides
- Microbial infections and disease research
Tezpur University
2009-2024
Post Graduate Institute of Medical Education and Research
2024
Chandigarh University
2023-2024
Barrow Neurological Institute
2024
Panjab University
2017-2021
Indian Institute of Science Bangalore
2012-2018
Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan
2016
King's College London
2013
Diabetes is a group of metabolic disorders characterized by elevated blood sugar levels, leading to many undesirable health consequences. There are herbal formulations, traditionally used the Northeast Indian population for disease management. These formulations require scientific validations optimize their efficacy and increase popularity. In this study, we attempt scientifically validate polyherbal formulation management diabetes through preliminary phytochemicals investigation,...
Traumatic brain injury (TBI) heterogeneity remains a critical barrier to translating therapies. Identifying final common pathways/molecular signatures that integrate this informs biomarker and therapeutic-target development. We present the first large-scale murine single-cell atlas of transcriptomic response TBI (334,376 cells) across clinically relevant models, sex, region, time as foundational step in molecularly deconstructing heterogeneity. Results were unique cell populations, regions,...
Transcription is an intricate mechanism and orchestrated at the promoter region. The cognate motifs in promoters are observed only a subset of total genes across different domains life. Hence, sequence-motif based prediction may not be holistic approach for whole genomes. Conversely, DNA structural property, duplex stability characteristic can used to delineate them from other genomic sequences. In this study, we have algorithm 'PromPredict' broad range eukaryotes, representing various...
Archaea are a vast and unexplored cellular domain that thrive in high diversity of environments, having central roles processes mediating global carbon nutrient fluxes. For these organisms to balance their metabolism, the appropriate regulation gene expression is essential. A key momentum regulating genes responsible for life maintenance archaea when transcription factor proteins bind promoter element. This DNA segment conserved, which enables its exploration by machine learning techniques....
Bacterial promoters play a crucial role in gene expression by serving as docking sites for the transcription initiation machinery. However, accurately identifying promoter regions bacterial genomes remains challenge due to their diverse architecture and variations. In this study, we propose MLDSPP (Machine Learning Duplex Stability based Promoter prediction Prokaryotes), machine learning-based tool, comprehensively screen 12 genomes. We leveraged biologically relevant informative DNA...
Introduction The propensity of nucleotide bases to form pairs, causes folding and the formation secondary structure in RNA. Therefore, purine (R): pyrimidine (Y) base-pairing is vital maintain uniform lateral dimension RNA structure. Transversions or base substitutions between R Y bases, are more detrimental stability structure, than transitions derived from A G C T. study transversion transition important understand evolutionary mechanisms 5′ 3′ untranslated (UTR) regions SARS-CoV-2. In...
Management of chronic obesity-associated metabolic disorders is a key challenge for biomedical researchers. During obesity, visceral adipose tissue (VAT) undergoes substantial transformation characterized by unique lipid-rich hypoxic AT microenvironment (ATenv) which plays crucial role in VAT dysfunction, leading to insulin resistance (IR) and type 2 diabetes(T2D). Here, we demonstrate that obese ATenv triggers the release miR-210-3p microRNA-loaded extracellular vesicles (EVs) from...
All approved coronavirus disease 2019 (COVID-19) vaccines in current use are safe, effective, and reduce the risk of severe illness. Although data on immunological presentation patients with COVID-19 is limited, increasing experimental evidence supports significant contribution B T cells towards resolution acute respiratory syndrome 2 (SARS-CoV-2) infection. Despite availability several high efficacy, more effective still needed to protect against new variants SARS-CoV-2. Employing a...
The Application of a combination enzymes is the best alternative to reduce use chemicals in paper industry. Bacillus sp. NG-27 and nealsonii PN-11 are known produce thermoalkali stable xylanse (X) mannanase (M) respectively having potential for pulp biobleaching. Present study, reports production mixture X + M by co-culturing strains SSF standardizing its application Production co-cultivation was optimized statistical methods. Substantial increase yield enzymes; 3.61 fold xylanase 37.71...
Under the condition of chronic obesity, an increased level free fatty acids along with low oxygen tension in adipose tissue creates a pathophysiological microenvironment (ATenv), leading to impairment adipocyte function and insulin resistance. Here, we found synergistic effect hypoxia lipid (H + L) surge fostering macrophage (ATM) inflammation polarization. ATenv significantly miR-210-3p expression ATMs which promotes NF-κB activation–dependent proinflammatory cytokine downregulation...
The transcriptional regulator PehR regulates the synthesis of extracellular plant cell wall-degrading enzyme polygalacturonase, which is essential in bacterial wilt plants caused by one most devastating phytopathogens, Ralstonia solanacearum. bacterium has a wide global distribution infecting many different species, resulting massive agricultural and economic losses. Because molecular structure not yet been determined structural consequences on ligand binding have thoroughly investigated, we...
Abstract The decreasing cost of whole genome sequencing has produced high volumes genomic information that require annotation. experimental identification promoter sequences, pivotal for regulating gene expression, is a laborious and cost-prohibitive task. To expedite this, we introduce the Comprehensive Directory Bacterial Promoters (CDBProm), directory in-silico predicted bacterial sequences. We first identified an Extreme Gradient Boosting (XGBoost) algorithm would distinguish promoters...
Chargaff's rule of intra-strand parity (ISP) between complementary mono/oligonucleotides in chromosomes is well established the scientific literature. Although a large numbers papers have been published citing works and discussions on ISP genomic era, scientists are yet to find all factors responsible for such universal phenomenon chromosomes. In present work, we tried address issue from new perspective, which parallel feature ISP. The compositional abundance values were determined...