A5066031961- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Meningioma and schwannoma management
- Traumatic Brain Injury and Neurovascular Disturbances
- Moyamoya disease diagnosis and treatment
- Cerebrospinal fluid and hydrocephalus
- Trigeminal Neuralgia and Treatments
- Neurological Complications and Syndromes
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Pharmacological Effects and Toxicity Studies
- Single-cell and spatial transcriptomics
- Mast cells and histamine
- melanin and skin pigmentation
- Spinal Dysraphism and Malformations
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Cell Adhesion Molecules Research
- Neonatal Respiratory Health Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Head and Neck Surgical Oncology
St. Joseph's Hospital and Medical Center
2023-2025
Barrow Neurological Institute
2023-2025
Brown University
2021-2023
Traumatic brain injury (TBI) heterogeneity remains a critical barrier to translating therapies. Identifying final common pathways/molecular signatures that integrate this informs biomarker and therapeutic-target development. We present the first large-scale murine single-cell atlas of transcriptomic response TBI (334,376 cells) across clinically relevant models, sex, region, time as foundational step in molecularly deconstructing heterogeneity. Results were unique cell populations, regions,...
Racial and socioeconomic health disparities are well documented in the literature. This study examined patient demographics, including status (SES), among individuals presenting with aneurysmal subarachnoid hemorrhage (aSAH) unruptured intracranial aneurysm (UIA) to identify factors associated aSAH presentation. A retrospective assessment was conducted of all patients UIA who presented a large-volume cerebrovascular center underwent microsurgical treatment from January 2014 through July...
Background: Giant intracranial aneurysms (GIAs), defined as exceeding 25 mm in diameter, represent one of the most formidable challenges neurosurgery. Compared to smaller aneurysms, GIAs carry a higher risk mass effect, thromboembolism, and hemorrhage due increased pressure wide necks resulting poorer outcomes.
Posterior reversible encephalopathy syndrome is a multifactorial neurological disorder characterized by clinical and neuroimaging findings. The “vasogenic theory” suggests that, in this condition, disrupted cerebrovascular autoregulation leads to blood‐brain barrier failure vasogenic edema. commonly associated with hypertension, chemotherapy, transplantation, but neurosurgical patients, including those undergoing digital subtraction angiography, are also at elevated risk. A patient history...
INTRODUCTION: Pediatric brainstem cavernous malformations (BSCMs) pose challenges due to the lack of standardized management guidelines. Microsurgical resection has shown increasing promise; however, postoperative course pediatric BSCMs not been extensively documented because rarity these lesions and difficulty microsurgical resection. METHODS: We retrospectively studied 693 patients who underwent surgery for a BSCM between 1984 2023 at three institutions (620 adult, 73 pediatric). Data...
BACKGROUND Extra-axial cavernous malformations (CMs) in the cerebellopontine angle (CPA) are rare, typically affect cranial nerves (CNs), and present significant therapeutic challenges. This report discusses case of a patient with an extra-axial CM CPA involving CN VII/VIII complex, alongside systematic review similar cases. OBSERVATIONS A literature search PubMed Embase databases identified 216 articles, 18 meeting inclusion criteria, encompassing 21 cases (average age 42.6 years). The most...
Exaggerated Type 2 immune responses play critical roles in the pathogenesis of a variety diseases including asthma, allergy, and pulmonary fibrosis. Recent studies have highlighted importance innate type lymphoid cells (ILC2s) these disorders. However, mechanisms that control development (IT2IR) recruitment and/or activation ILC2 are poorly understood. In mouse models IT2IR, we demonstrated phospholipid scramblase-1 (PLSCR1), II transmembrane protein mediates bidirectional nonspecific...
Background Approximately 3.2%–6% of the general population harbor an unruptured intracranial aneurysm (UIA). Ruptured aneurysms represent a significant healthcare burden, and preventing rupture relies on early detection treatment. Most patients with UIAs are asymptomatic, many symptoms associated nonspecific, which makes diagnosis challenging. This study explored UIAs, rate resolution such after microsurgical treatment, likely pathophysiology. Methods A retrospective review who underwent...
OBJECTIVE An anatomical taxonomy has been established to guide surgical approach selection for resecting brainstem and deep superficial cerebral cavernous malformations (CMs). The authors propose a novel cerebellar CMs, introduce 6 distinct neuroanatomical subtypes, assess their clinical outcomes. METHODS This bi-institutional, 2-surgeon cohort study included 143 CMs that were microsurgically treated over 25-year period. proposed classifies into subtypes on the basis of location as...
Neurosurgical complications are a rich source for learning, but they grossly underutilized the purpose of surgeon education. Details complications, which make them all more powerful as teaching tools, restricted to morbidity and mortality conferences behind closed doors, open discussions topic blurred by hypotheticals in order shield presenters from medicolegal risks. In this issue Focus, 9 neurosurgeons were invited present encountered along with details specific lessons learned. The...
BACKGROUND AND IMPORTANCE: The surgical management of posterior inferior cerebellar artery (PICA) aneurysms often poses a challenge because tight corridors, proximity to the lower cranial nerves, and presence perforators supplying medulla. This report describes an excision double reimplantation bypass for treatment dolichoectatic PICA aneurysm found on familial screening in young man with family history aneurysmal subarachnoid hemorrhage. CLINICAL PRESENTATION: patient underwent right...