A5089925649- Traumatic Brain Injury and Neurovascular Disturbances
- Bacterial biofilms and quorum sensing
- Neuroinflammation and Neurodegeneration Mechanisms
- Nanoparticles: synthesis and applications
- Essential Oils and Antimicrobial Activity
- S100 Proteins and Annexins
- Cholesterol and Lipid Metabolism
- Microbial Community Ecology and Physiology
- Acute Ischemic Stroke Management
- Textile materials and evaluations
- Natural Products and Biological Research
- Neonatal and fetal brain pathology
- Chemical and Physical Properties in Aqueous Solutions
- Proteins in Food Systems
- Phagocytosis and Immune Regulation
- Gene expression and cancer classification
- Microbial Inactivation Methods
- Crystallization and Solubility Studies
- Genetics and Neurodevelopmental Disorders
- Genetics, Bioinformatics, and Biomedical Research
- Delphi Technique in Research
- Mitochondrial Function and Pathology
- Analytical Chemistry and Chromatography
- Cardiac Ischemia and Reperfusion
- Microencapsulation and Drying Processes
Barrow Neurological Institute
2021-2024
Dow University of Health Sciences
2024
St. Joseph's Hospital and Medical Center
2020-2023
Vellore Institute of Technology University
2017-2018
Central Food Technological Research Institute
2016
Banaras Hindu University
2014-2015
National Dairy Research Institute
2013-2015
Traumatic brain injury (TBI) heterogeneity remains a critical barrier to translating therapies. Identifying final common pathways/molecular signatures that integrate this informs biomarker and therapeutic-target development. We present the first large-scale murine single-cell atlas of transcriptomic response TBI (334,376 cells) across clinically relevant models, sex, region, time as foundational step in molecularly deconstructing heterogeneity. Results were unique cell populations, regions,...
Yeast was encapsulated using different carrier materials and their combinations to explore the possible synergistic effect of material during encapsulation spray drying. Freeze-drying performed for comparison. The dried cell powders were analyzed quality aspects (morphology, flowability, storage stability). best results observed, with a combination whey protein corn starch (cell survival: 82.37% yield: 56%, w/w) shelf life 6 months (with only 10% reduction in survival). survival found be 40%...
An efficient, fast, and reliable reversed phase high-performance liquid chromatography based method was developed to detect specific adulterant in premium pure ghee (clarified butterfat) samples. The is on the detection of cholesterol β-sitosterol as markers unsaponifiable matter adulterated samples, respectively. resolved cholesterol, stigmasterol, campasterol, at Rt values 17.681 ± 0.122, 19.7 0.2, 20.2 22.7 0.2 min., served an indicator for adulteration by plant oil dose dependent manner...
Fragile X mental retardation protein (FMRP) is a neuronal translational repressor and has been implicated in learning, memory, cognition. However, the role of Bacopa monnieri extract (CDRI-08) enhancing cognitive abilities hypoxia-induced memory impairment via Fmr-1 gene expression not known. Here, we have studied effects CDRI-08 on hippocampus well validated cobalt chloride (CoCl 2 )-induced hypoxia mimetic mice analyzed data with alterations spatial memory. Results obtained from Morris...
Addressing traumatic brain injury (TBI) heterogeneity is increasingly recognized as essential for therapy translation given the long history of failed clinical trials. We evaluated differential effects a promising treatment (glibenclamide) based on dose, TBI type (patient selection), and imaging endophenotype (outcome selection). Our goal to inform precision medicine contextually timely ongoing phase 2/planned 3 trials glibenclamide in contusion.Blinded randomized controlled preclinical...
Aqueous two-phase extraction has been effectively used for the separation and purification of several biological molecules. The main advantages aqueous are biocompatibility, scope continuous operation, process integration ease scale up. In downstream processing, found its applications in extraction, concentration various biomolecules. this review, some systemsemployed processing besides basic aspects a few case studies presented. Some recent developments with regard to reviewed future...
Statistics and Mathematical models can be in many forms, including differential equations, or theoretic models. Lack of correlation between theoretical mathematical experimental measurements sometime leads to development better theories the area biology. The design finds wide application nutrient media optimization for microbial enzyme production. On other hand these tools field statistics play an important role with data analysis proteomics genomics studies. For MS/MS spectroscopic data,...
The recent advances in stroke management have given rise to the so-called ‘precision’ strokes designed and tailored meet diverse challenges that are associated with this brain vascular condition. Objectives: main of study is find precision approaches management, as well advances, challenges, innovations acute secondary prevention strategies. Methods: This retrospective was conducted at Services Hospital Lahore from August 2022 November 2023. Data were collected 220 patients stroke. Patient...
<h3>Objective:</h3> To evaluate cell-specific changes in sulfonylurea-receptor-1 (SUR1)-transient receptor melastatin-4 (TRPM4) related pathway gene expression activity and biological processes by single-cell RNA sequencing (scRNA-Seq) across increasing severity of murine traumatic brain injury (TBI). <h3>Background:</h3> SUR1-TRPM4 inhibition is being evaluated a phase-II TBI trial, however genes upstream/downstream this channel may also be impacted differentially cell types at the site. We...
<h3>Objective:</h3> To explore how age influences sulfonylurea-receptor-1 (SUR1)-related genes and biological processes across cell subtypes of the murine brain by using single RNA sequencing (scRNA-Seq). <h3>Background:</h3> SUR1-inhibition therapy is a promising therapeutic strategy being evaluated in phase-II trial to improve secondary injuries after traumatic injury (TBI). The impact this may vary with depending on related differences gene expression/biological processes....
To evaluate sexual dimorphism at a single-cell (SC) level in genes related to sulfonylurea-receptor-1 (SUR1).