A5023406371- Meningioma and schwannoma management
- Intracranial Aneurysms: Treatment and Complications
- Spinal Dysraphism and Malformations
- Cerebrospinal fluid and hydrocephalus
- Vascular Malformations Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Glioma Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Neurofibromatosis and Schwannoma Cases
- Hereditary Neurological Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Genetic and Kidney Cyst Diseases
- Genomics and Rare Diseases
- Cerebrovascular and Carotid Artery Diseases
- Head and Neck Surgical Oncology
- Cell Adhesion Molecules Research
- Hedgehog Signaling Pathway Studies
- Urinary Bladder and Prostate Research
- Genetics and Neurodevelopmental Disorders
- Neurological diseases and metabolism
- Genomic variations and chromosomal abnormalities
- Spine and Intervertebral Disc Pathology
- Congenital heart defects research
- Moyamoya disease diagnosis and treatment
- Congenital Anomalies and Fetal Surgery
Marmara University
2016-2025
Acıbadem University
2023
Koç University
2023
Amerikan Hastanesi
2023
Kent Hastanesi
2018
Acıbadem Adana Hospital
2018
Oxford University Press (United Kingdom)
2018
Institute of Neurological Sciences
2012
Yale University
2007-2010
Ondokuz Mayıs University
2009-2010
Genetic Clues to Meningioma Meningiomas are the most common primary brain tumors in adults. Located within layer of tissue covering brain, these usually slow-growing and benign but can cause serious neurological complications. About half have mutations neurofibromin 2 gene ( NF2 ). To identify other genes that contribute meningioma pathogenesis, Clark et al. (p. 1077 , published online 24 January) performed genome sequence analysis on 300 tumors. fell into two general classes: located at...
OBJECTIVE Recent large-cohort sequencing studies have investigated the genomic landscape of meningiomas, identifying somatic coding alterations in NF2 , SMARCB1 SMARCE1 TRAF7, KLF4, POLR2A BAP1 and members PI3K Hedgehog signaling pathways. Initial associations between clinical features subgroups been described, including location, grade, histology. However, further investigation using an expanded collection samples is needed to confirm previous findings, as well elucidate relationships not...
Introduction: Intracranial aneurysms (IAs) are abnormal dilations of brain arteries that can result in high mortality and morbidity when they rupture. Our study provides a spatial characterization 11 human IA tissues by utilizing transcriptomics proteomics with 6,000 RNA 64 protein markers, serving as comprehensive atlas the microenvironment. Methodology: Nanostring CosMX platform was used to spatially characterize proteomic transcriptomic profile IA- parental vessel wall fresh-frozen or...
Abstract Hedgehog signaling mediates embryologic development of the central nervous system and other tissues is frequently hijacked by neoplasia to facilitate uncontrolled cellular proliferation. Meningiomas, most common primary brain tumor, exhibit activation in 6.5% cases, triggered recurrent mutations pathway mediators such as SMO . In this study, we find 35.6% meningiomas that lack previously known drivers acquired various types somatic structural variations affecting chromosomes 2q35...
This study aims to evaluate the safety and efficacy of flow diverters (FDs) in treatment middle cerebral artery (MCA) aneurysms share follow-up (F/U) results.The F/U results 76 MCA treated with re-direction endoluminal device (FRED), FRED Jr., pipeline embolization (PED) FD stents were evaluated retrospectively. The aneurysm occlusion rates compared between FDs, integrated jailed branches through follow-ups. oversizing stent was occluded/non-occluded branches.The mean duration 32 ± 6.3...
Tenascin is an extracellular matrix glycoprotein that expressed during embryogenesis, inflammation, angiogenesis, and carcinogenesis. The aim of this study was to investigate how tenascin expression relates histological grade, radiological findings in meningiomas.Twenty typical, 20 atypical, 5 malignant meningiomas were studied retrospectively. vascular endothelial growth factor (VEGF) the tumor tissue investigated by immunohistochemistry. messenger ribonucleic acid also comparative reverse...
Abstract Background To investigate the imaging findings and clinical features of multinodular vacuolating neuronal tumor (MVNT). Methods We retrospectively sought for cases that have suspicious MVNT through hospital information system. The patients’ demographics symptoms were extracted. All available images re-examined. Results Headache was most common complaint ( n = 7). Other complaints included seizure, stroke-like numbness. Conventional MRI revealed all lesions consisted tiny, sharply...
Object Angiogenesis and the platelet-derived growth factor (PDGF) pathway are active in pathogenesis of vestibular schwannomas (VSs). The purpose this study was to test whether imatinib mesylate (Gleevec), a PDGF receptor (PDGFR) blocker, reduces angiogenic capacity sporadic VS associated with neurofibromatosis Type 2 (NF2) using corneal angiogenesis assay. Methods From 121 tissue samples stored tumor bank at Marmara University Institute Neurological Sciences, 10 (6 from cases, 4...