A5044496753- Veterinary Equine Medical Research
- Reproductive Physiology in Livestock
- Ruminant Nutrition and Digestive Physiology
- Muscle metabolism and nutrition
- Exercise and Physiological Responses
- Growth Hormone and Insulin-like Growth Factors
- Genetic and phenotypic traits in livestock
- Sepsis Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Effects of Environmental Stressors on Livestock
- Tendon Structure and Treatment
- Metabolism, Diabetes, and Cancer
- Thermal Regulation in Medicine
- Adipose Tissue and Metabolism
- Hemodynamic Monitoring and Therapy
- Myofascial pain diagnosis and treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Magnesium in Health and Disease
- Diabetes and associated disorders
- Animal health and immunology
- Entomological Studies and Ecology
- Pregnancy-related medical research
- Women's cancer prevention and management
- Potassium and Related Disorders
- Pharmacological Effects and Assays
The Ohio State University
2016-2025
Center for Veterinary Medicine
2011
Background: Insulin resistance has been associated with risk of laminitis in horses. Genes coding for proinflammatory cytokines and chemokines are expressed more visceral adipose tissue than subcutaneous insulin-resistant (IR) humans rodents. Hypothesis/Objectives: To investigate depot-specific cytokine chemokine gene expression horses its relationship to insulin sensitivity (SI). Animals: Eleven light breed mares. Methods: Animals were classified as IR (SI = 0.58 ± 0.31 × 10−4 L/min/mU; n...
Background The original equine sepsis score provided a method of identifying foals with sepsis. New variables associated have been evaluated, but the has not updated. Objectives To evaluate sensitivity and specificity 2 updated scores systemic inflammatory response syndrome (SIRS) criteria in regard to detecting foals. Animals Two‐hundred seventy‐three ill 25 healthy control Methods Historical, physical examination, clinicopathologic findings were used calculate scores. SIRS also evaluated....
Background: Insulin resistance (IR) has been widely recognized in humans, and more recently horses, but its underlying mechanisms are still not well understood. The translocation of glucose transporter 4 (GLUT4) to the cell surface is limiting step for uptake insulin‐sensitive tissues. Although downstream signaling pathways regulating GLUT defined, AS160 emerged as a potential key component. In addition, role GLUT12, one most identified GLUTs, during IR unknown. Hypothesis/Objectives: We...
Hyperinsulinaemia has been implicated in the pathogenesis of laminitis; however, laminar cell types responding to insulin remain poorly characterised.To identify expressing receptor (IRc) and/or insulin-like growth factor-1 (IGF-1R); and evaluate effect dietary nonstructural carbohydrate (NSC) on their expression.Mixed-breed ponies (n = 22) received a conditioning hay chop diet (NSC ∼6%); following acclimation, were stratified into lean 11, body condition score [BCS]≤4) or obese BCS ≥7)...
Background Several tests have been evaluated in horses for quantifying insulin dysregulation to support a diagnosis of equine metabolic syndrome. Comparing the performance these same will provide clarification their accuracy dysregulation. Objectives The aim this study was evaluate agreement between basal serum concentrations ( BIC ), oral sugar test OST combined glucose‐insulin CGIT and frequently sampled insulin‐modified intravenous glucose tolerance FSIGTT ). Animals Twelve healthy,...
Insulin dysregulation, obesity, and exposure to high-nonstructural carbohydrate (NSC) forage are risk factors for equine metabolic syndrome-associated laminitis (EMSAL); high systemic insulin concentrations in EMSAL proposed induce cellular dysregulation the digital lamellae through activation of insulin-like growth factor-1 receptor.To use a dietary challenge model (DCM) euglycaemic-hyperinsulinaemic clamp (EHC) assess lamellar factor-related signalling.Lamellar phospho (P)-protein...
Corticosteroids are used routinely in horses and induce insulin dysregulation (ID). Nutrition is important for ID management includes low nonstructural carbohydrate (NSC) diets and, often, high-protein ration balancers (RB). Insulin incretin secretion increase after meals; corticosteroids may influence these effects. A mixed meal will hyperinsulinemia increased concentrations of glucose-dependent insulinotropic polypeptide (GIP) glucagon-like peptide 1 (GLP-1) with ID; dexamethasone (DEX)...
ABSTRACT Background Sepsis has been defined in humans as the concurrent proven or suspected presence of microbial infection and systemic inflammatory response syndrome (SIRS). is leading cause morbidity mortality neonatal foals. The clinical utility using SIRS its individual components to predict critically ill foals currently unknown. Objectives Assess ability history signalment, findings, laboratory results, SIRS‐related indices Animals Retrospective, multi‐center, cross‐sectional study a...
Paraherquamide is a novel natural anthelmintic product with mode of action that incompletely characterized. Nicotine and cholinergic-anthelmintic agonists different chemical classes were used to produce contraction in <i>Ascaris</i> muscle strips. semisynthetic derivative, 2-deoxy-paraherquamide, antagonized these responses. Analysis the actions antagonists was made using simple competitive model nonlinear regression estimate p<i>K</i><sub>B</sub> values antagonists. The analysis tested...
Abstract Background The neutrophil‐lymphocyte ratio (NLR) in human medicine is an objective biomarker that reflects prognosis. NLR as independent to help predict nonsurvival hospitalized neonatal foals has not been thoroughly interrogated. Objectives/Hypothesis Retrospectively evaluate if the at admission associated with sick <4 days old. We hypothesized a lower will be nonsurvival. Animals One thousand one hundred ninety‐six client‐owned old of any breed and sex: 993 203 healthy foals....
Summary Reasons for performing study Acute, massive enteral carbohydrate overload is associated with laminar inflammation in equids; it unclear if the same true a more prolonged period of moderate dietary intake. Objectives To characterise ponies exposed to challenge meant mimic acute pasture exposure. Study design In vivo experiment. Methods Mixed‐breed (n = 22) received diet hay chop (nonstructural [ NSC ] ∼7% on dry matter DM basis) 4 weeks prior initiation experimental feeding protocol....
Hyperinsulinaemia is implicated in the pathogenesis of endocrinopathic laminitis. Insulin can bind to different receptors: two insulin receptor isoforms (InsR-A and InsR-B), insulin-like growth factor-1 (IGF-1R) InsR/IGF-1R hybrid (Hybrid). Currently, mRNA expression these receptors equine tissues influence body type dietary carbohydrate intake on not known.The study objectives were characterise InsR-A, InsR-B, IGF-1R Hybrid lamellar tissue (LT) responsive from horses examine effect...
Abstract Background Hyperinsulinemia is associated with equine laminitis, and digital lamellar inflammation in metabolic syndrome‐associated laminitis (EMSAL) modest when compared sepsis‐associated laminitis. Objectives To characterize horses a euglycemic‐hyperinsulinemic clamp (EHC) model of Animals Sixteen healthy adult Standardbred horses. Methods Prospective experimental study. Horses underwent EHC or saline infusion (CON) for 48 hours until the onset Obel grade 1 were euthanized, tissue...
Background: Oxidative stress reportedly plays a role in sepsis‐induced organ dysfunction and failure many species. In septic horses, laminae are targeted; evidence of laminar oxidative has been reported experimentally the black walnut extract (BWE) model. Carbohydrate (CHO)‐induced laminitis may be more similar to clinical sepsis‐related than BWE model that animals with CHO‐induced disease commonly develop failure. The CHO remains unknown. Hypothesis/Objectives: Markers will increased from...
Abstract Background The enteroinsular axis (EIA) comprises intestinal factors (incretins) that stimulate insulin release after PO ingestion of nutrients. Glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) are the main incretins. EIA has not been investigated in healthy neonatal foals but should be important because energy demands high dysregulation is frequent sick foals. Objectives Hypothesis To evaluate response to carbohydrates or fasting newborn We...
Cobalt chloride (CoCl2 ) is administered to racehorses enhance performance. The purpose of this study was evaluate the clinical, cardiovascular, and endocrine effects parenterally CoCl2 .To describe weekly intravenous doses on Standardbred horses.Five, healthy mares.Prospective, randomized, experimental dose-escalation pilot. Five mares were assigned receive 1 5 (4, 2, 1, 0.5, or 0.25 mg/kg) IV for weeks. Physical examination, blood pressure, cardiac output, electrocardiography (ECG)...
Background In EMS ‐associated laminitis, laminar failure may occur in response to energy related insulin resistance ( IR ) or the effect of hyperinsulinemia on tissue. 5′‐Adenosine‐monophosphate‐activated protein kinase AMPK is a marker tissue deprivation, which . Hypothesis/Objectives To characterize regulation ponies subjected dietary carbohydrate CHO challenge. Animals Twenty‐two mixed‐breed ponies. Methods Immunohistochemistry and immunoblotting for total phospho(P)‐AMPK RT‐ qPCR...
The purpose of this study was to explore participants’ perceived benefits equine-assisted psychotherapy and understand if older adults with functional or cognitive impairment found meaning in their interactions horses. This employed a mixed methods design concurrent triangulation approach. findings from our suggest that those impacted can meaningfully engage EAGALA model demonstrate the ability find experience. Their were not limited horses but instead wide-ranging, including positive...
Interleukin-6 (IL-6) is consistently increased in the digital lamellae different studies of sepsis-related laminitis (SRL). IL-6 signalling through gp130 receptor activates similar (i.e. mTORC1-related signalling) previously reported to be activated models endocrinopathic laminitis.To assess activation state proteins downstream IL-6/gp130 complex an experimental model SRL.Randomised study.Lamellar phospho-(P) protein concentrations receptors were assessed oligofructose (OF) SRL. Fifteen...