Abstract The parasitic nematode Ascaris suum is an economically significant worm that infects pigs and causes health issues economic losses in pig farming. intestine of A. a long, straight tube runs from the mouth to anus can be colonized by bacteria. Several bacteria have been studied for their potential antinematocidal effects. Bacillus thuringiensis (Bt), soil bacterium known produce many toxic crystal proteins (Cry), emerging as promising candidate control. Treatment with all tested Bt...

Paraherquamide is a novel natural anthelmintic product with mode of action that incompletely characterized. Nicotine and cholinergic-anthelmintic agonists different chemical classes were used to produce contraction in <i>Ascaris</i> muscle strips. semisynthetic derivative, 2-deoxy-paraherquamide, antagonized these responses. Analysis the actions antagonists was made using simple competitive model nonlinear regression estimate p<i>K</i>_B values antagonists. The analysis tested...

Ivermectin is considered a very safe drug; however, there are reports of toxic effects in particularly sensitive populations or due to accidental overdose. The aim this study was (1) further characterize the central and peripheral ivermectin animals (2) determine possible therapeutic strategies for use cases poisoning. We tested experimental doses previously reported cause various intensities CNS depression. However, our study, at 2.5, 5.0 7.5 mg/kg i.v. did not produce visible depression...

The control of parasitic nematode infections relies mostly on anthelmintics. potential pharmacotherapeutic application phytochemicals, in order to overcome parasite resistance and enhance the effect existing drugs, is becoming increasingly important. antinematodal effects carveol was tested free-living

The aim of our study was to determine the efficacy three different adsorbents, inorganic (modified zeolite), organic (esterified glucomannans) and mixed (inorganic components, with addition enzymes), in protecting broilers from toxic effects ochratoxin A feed. Broilers were fed diets containing 2 mg/kg (OTA) supplemented adsorbents at recommended concentration g/kg for 21 days. presence OTA led a notable reduction body weight, lower weight gain, increased feed conversion induced...

Parascaris sp. is the only ascarid parasitic nematode in equids and one of most threatening infectious organisms horses. Only a limited number compounds are available for treatment horse helminthiasis, worms have developed resistance to three major anthelmintic families. In order overcome appearance resistance, there an urgent need new therapeutic strategies. The active ingredients herbal essential oils potentially effective antiparasitic drugs. Carvacrol principal chemicals oil from...

The ongoing and widespread emergence of resistance to the existing anti-nematodal pharmacopeia has made it imperative develop new anthelminthic agents. Historically, plants have been important sources therapeutic compounds offer an alternative synthetic drugs. Monoterpenoids are phytochemicals that shown produce acute toxic effects in insects nematodes. Previous studies nicotinic acetylcholine receptors (nAChRs) be possible targets for naturally occurring plant metabolites such as carvacrol...

Abstract 1. The objective of this study was to investigate in vitro and vivo (in broiler chickens) ochratoxin A (OTA) adsorption efficiency three different adsorbents: inorganic (modified zeolite); organic (esterified glucomannans) mixed (inorganic components plus enzymes). 2. aim the which these adsorbents provided best protection against presence residues OTA pectoral muscle liver broilers given an OTA-contaminated diet. In addition, it important test compare results adsorbent using two...

Carvacrol (CRV) is the main compound of essential oils extracted primarily from Thymus and Origanum species. Its various biological activities were confirmed: antioxidant, anti-inflammatory, antibacterial, antifungal, anti-tumour, antinematodal, vasorelaxant action. Although vasodilation mediated by CRV was previously described, exact mechanism its action has not yet been established. Hence, aim this study to investigate vasoactivity on human umbilical arteries (HUA) different pathways...

This experimental study was conducted to determine the ability of a novel mycotoxins detoxification agent (MR) at concentration 0.2% reduce toxicity aflatoxin B1 (AFB1) or T-2 toxin, alone in combination, and examine its effect on performance, pathohistological changes (PH) residue these toxins tissues broiler chicks. A total 96 chicks were divided into eight equal groups: group C, which served as control (without any additives); MR, received (supplemented with 0.2%); E-I (0.1 mg AFB1/kg...

Eugenol, an essential oil of clove possesses several different pharmacological properties, including antimicrobial, antifungal, insecticidal and antihelmintic. With regard to the digestive tract, eugenol has shown spasmolitic relaxant effects. To elucidate some mechanisms involved, effects on contractions isolated rat ileum induced by electrical field stimulation (EFS) were investigated. Eugenol (100 µM) significantly reversibly reduced EFS approximately 80%. Control 2.00±0.18 g, while in...

The 42-day long study was performed on a total number of 48 Hybro broilers divided into four groups. After the pre-experimental period 14 days, 3 experimental groups (n=12) were formed and fed diets that contained 0.5, 1.0 1.5 mg/kg ochratoxin A (OTA) during next seven consecutive days. In same period, control group diet with no toxin added. addition, blood samples taken from 6 animals in each group. remaining (n=6) without OTA until 42nd day study, when again. level serum proteins affected...

Abstract In the present study we tested dose andh time dependence of antinematodal effects carvacrol and tyhmol on Caenorabditis elegans, efficacy carvacrol, thymol, p-cymene cinnamaldehyde,which were administrated in drinking water rats naturally infected with pinworm Syphacia muris . The control treatment was carried out piperazine. Thymol caused a time-dependent mortality adult C. elegans value Median Lethal Concentration (LC 50 ) thymol 117.9nM after 24h 62.89 nM 48h exposure. Carvacrol...

SUMMARY A two-micropipette current-clamp technique was used to record electrophysiological responses from the somatic muscle of Ascaris suum. Levamisole and acetylcholine were applied bag region using a microperfusion system. Depolarizations produced by 10 s applications μmol l-1 levamisole or 20 recorded. The effect on peak membrane potential change kinase antagonists H-7, staurosporine, KN-93 genistein observed. H-7 (30 l-1), non-selective antagonist protein kinases A, C G but which has...

Zolvix® is a recently introduced anthelmintic drench containing monepantel as the active ingredient. Monepantel positive allosteric modulator of DEG-3/DES-2 type nicotinic acetylcholine receptors (nAChRs) in several nematode species. The drug has been reported to produce hypercontraction Caenorhabditis elegans and Haemonchus contortus somatic muscle. We investigated effects on nAChRs from Ascaris suum Oesophagostomum dentatum heterologously expressed Xenopus laevis oocytes. Using...

Giant liver fluke ( Fascioloides magna ) infection is an important health problem of cervids in southeastern Europe. We measured the prevalence and intensity with F. a fenced area near Danube River South Bačka District Serbia. Parasitologic, pathomorphologic, histopathologic examinations were conducted from November 2007 to February 2008, beginning population 127 adult fallow deer Dama dama ). After positive diagnosis, therapy triclabendazole-medicated corn was applied. Deer treated at four...

Abstract This study investigated whether the L-arginine-NO system participates in analgesic effect of flunixin meglumine rat. Hyperalgesia was induced by intraplantar (i.pl.) administration carrageenan (500 μg) into rat’s hind paw. Electronic von Frey apparatus used to determine paw withdrawal threshold pressure as painful stimulus, measured grams (g). Flunixin (FM; 0.09-0.1 mg/kg; s.c.) and N G -nitro-L-arginine methyl ester (L-NAME; 10 i.p.), given separately a pre-treatment, i.e. 15 min...