A5062589661- Childhood Cancer Survivors' Quality of Life
- Hematopoietic Stem Cell Transplantation
- Palliative Care and End-of-Life Issues
- Adolescent and Pediatric Healthcare
- Acute Lymphoblastic Leukemia research
- Mobile Health and mHealth Applications
- Ethics and Legal Issues in Pediatric Healthcare
- Medication Adherence and Compliance
- Family Support in Illness
- Neutropenia and Cancer Infections
- Family and Disability Support Research
- Neuroblastoma Research and Treatments
- Renal Transplantation Outcomes and Treatments
- Health disparities and outcomes
- COVID-19 and Mental Health
- Pediatric Pain Management Techniques
- Digital Mental Health Interventions
- Acute Myeloid Leukemia Research
- Nursing Roles and Practices
- Hemoglobinopathies and Related Disorders
- Transplantation: Methods and Outcomes
- Pharmacological Effects and Toxicity Studies
- Pharmaceutical studies and practices
- Neonatal Health and Biochemistry
- COVID-19 and healthcare impacts
Nationwide Children's Hospital
2015-2025
The Ohio State University
2005-2025
Mount Carmel College of Nursing
2025
Macquarie University
2024
University of Wisconsin–Madison
2023
University School
2023
Cohen Children's Medical Center
2021
Lurie Children's Hospital
2021
Vanderbilt University
2014-2019
Bexley Hall
2019
ABSTRACT Purpose Caregivers in pediatric oncology need accurate and understandable information about their child's condition, treatment, side effects. This study assesses the performance of publicly accessible large language model (LLM)‐supported tools providing valuable reliable to caregivers children with cancer. Methods In this cross‐sectional study, we evaluated four LLM‐supported tools—ChatGPT (GPT‐4), Google Bard (Gemini Pro), Microsoft Bing Chat, SGE—against a set frequently asked...
Idiopathic pneumonia syndrome (IPS) is an acute, noninfectious lung disorder associated with high morbidity and mortality after hematopoietic cell transplantation. Previous studies have suggested a role for TNFα in the pathogenesis of IPS. We report multicenter phase II trial investigating soluble TNF-binding protein, etanercept (Enbrel, Amgen, Thousand Oaks, CA), treatment pediatric patients Eligible were < 18 years old, within 120 days transplantation, radiographic evidence diffuse...
Seprehvir (HSV1716) is an oncolytic herpes simplex virus-1 (HSV-1) previously demonstrated to be well tolerated in pediatric patients when administered intratumorally. To determine the safety of administering systemically, we conducted first-in-human phase I trial intravenous injection young with relapsed or refractory extra-cranial solid cancers. We delivered a single dose 5 × 104 infectious units (iu)/kg (maximum 2 106) 2.5 105 iu/kg 1 107 iu) via peripheral vein, monitored adverse events,...
Abstract Aim Little research exists on coronavirus (COVID‐19) vaccine hesitancy among caregivers of children with cancer. We aimed to (a) describe in parents cancer for both their child and self, (b) examine the mediating role parent‐reported COVID impact association between exposure hesitancy. Procedure conducted a national survey via Facebook Momcology, pediatric community‐based organization recruited February–May 2021. Parents completed standardized measures online. A series mediation...
Objective Hematopoietic stem cell transplant is a life-saving procedure that treats patients with various conditions by transplanting hematopoietic cells from bone marrow. Mobile health apps could be useful in closing the digital divide and improving equity among Spanish-speaking caregivers of children who undergo pediatric transplant. This study aims to transcreate BMT4me adherence app originally designed for English-speaking evaluate feasibility usability. Methods consists two phases....
Manning, Andrea Pifer DNP, RN, MBA, NEA-BC; Opperman, Cathleen NPD-BC CPN; Vegh, Maria MSN RN; Sutherland-Foggio, Malcolm BA; Brammer, Joan Modelewski NPD-BC; Skeens, Micah A. PhD, CPNP Author Information
This cross-sectional study explores the types of preventive and chronic care survivors childhood cancer pediatric bone marrow transplant receive from their primary providers. We also identified barriers perceived by to utilization care. Survivors were recruited a large Midwestern hospital completed demographic an eight-item semi-structured survey. Parents <18 years survey for child >18 on own. A total 259 caregivers (55.7%) 206 (44.3%) participated. The mean survivor age was 19.76 ( SD...
Objectives This study examined the perceptions of caregivers young childhood cancer survivors (YCCS) regarding use virtual assistant (VA) technology for health information seeking and care management. The aim was to understand how VAs can support caregivers, especially those from underserved communities, in navigating related survivorship. Methods A qualitative design employed, involving semi-structured interviews focus groups with 10 YCCS metropolitan, rural, Appalachian regions, recruited...
Anti-seizure prophylaxis is routinely utilized during busulfan administration for HSCT. We evaluated the feasibility and efficacy of levetiracetam in children undergoing A total 28 young adults received HSCT outcomes costs were compared to a historical, but similar cohort 25 patients who had fosphenytoin. Levetiracetam was well tolerated efficacious preventing seizures. Cost drug, administration, monitoring also among two groups. Due non-induction hepatic cytochrome P450 enzymes, may lead...
Parents/caregivers require specialized education in order to care for their child with a newly diagnosed cancer. Currently, no evidence-based guidelines exist identify content essential inclusion patient/family prior child’s initial discharge home; this study used Delphi methodology obtain multidisciplinary consensus regarding amongst pediatric oncology experts from the Children’s Oncology Group. Three questionnaire rounds were employed content, evaluate importance of educational topics...
Abstract Background Most patients with juvenile myelomonocytic leukemia (JMML) are curable only allogeneic hematopoietic cell transplantation (HCT). However, the current standard conditioning regimen, busulfan‐cyclophosphamide‐melphalan (Bu‐Cy‐Mel), may be associated higher risks of morbidity and mortality. ASCT1221 was designed to test whether potentially less‐toxic myeloablative regimen containing busulfan‐fludarabine (Bu‐Flu) would equivalent outcomes. Procedure Twenty‐seven were enrolled...
Management of symptom-related distress is an important area pediatric oncology nursing. Participants who attended the Children’s Oncology Group (COG) State Science Symposium on symptom completed anonymous survey. The purpose was to explore participant perceptions experienced by children receiving cancer treatment clinical trials, determine how currently assessed at COG institutions, and identify what interventions are used reduce for these children. Among 90 symposium attendees, 72% survey,...
Working in the pediatric intensive care unit (PICU) exposes nurses to intense and recurrent experiences with loss. Such may result unresolved grief or despair among these providers. Although previous studies have explored within nursing profession, few focused on following death of children PICU, where sudden traumatic deaths are more frequent. The aim this study was characterize degree which critical (PCC) experience symptoms distress suffering and/or a patient PICU.An email invited PICU at...
10005 Background: Neuroblastoma (NBL) is the most common extra-cranial solid tumor in children and outcomes for with relapsed/refractory (RR) NBL remain dismal. While combination of chemoimmunotherapy (CIT) anti-GD2 antibody dinutuximab as per COG protocol ANBL1221 has improved responses, this regimen still not curative. Dinutuximab can recruit NK cells anticancer activity, however, are depleted patients undergoing chemotherapy. We devised a method to expand allogeneic ex vivo improve...
Children and adolescents undergoing allogeneic hematopoietic cell transplantation (HCT) are at high risk for invasive fungal disease (IFD).This multicenter, randomized, open-label trial planned to enroll 560 children (3 months <21 years) HCT between April 2013 September 2016. Eligible patients were randomly assigned antifungal prophylaxis with caspofungin or a center-specific comparator triazole (fluconazole voriconazole). Prophylaxis was administered from day 0 of 42 discharge. The primary...
Abstract Congenital Amegakaryocytic Thrombocytopenia (CAMT) is a rare bone marrow failure syndrome that presents with isolated thrombocytopenia within the first year of life. Classic diagnostic findings reveal absent or significantly decreased megakaryocytes otherwise normal cellularity. We present newborn whose initial aspirate showed an appropriate number megakaryocytes. CAMT was subsequently diagnosed after molecular testing demonstrated mutation in thrombopoietin receptor. The presence...
MS and endocrine dysfunction(s) are common well-recognized complications after HSCT. We retrospectively analyzed our data on 160 patients with a median age at transplant of five yr (0.3-23), who had been followed for seven (range 3-18) Nationwide Children's Hospital transplant. Dyslipidemia were seen in 13% 7.5% patients, respectively, 58% these <20 age. Twelve met the criteria diagnosis MS, but four did not meet International Diabetic Federation or WHO criteria. Variation diagnostic leading...
COVID-19 resulted in mass quarantine measures early the pandemic. This disruption of daily life widened inequities and made children one most vulnerable populations during crisis. national, cross-sectional "COVID-Kids" study collected data from almost 500 parent-child dyads using standardized to better understand effects COVID exposure impact on children's quality loneliness. Data were via social media May July 2020. According parent proxy child self-report, United States experienced worse...
Abstract Objectives Adolescents with cancer often experience significant symptom burden and aggressive treatment near end-of-life. Increased adolescent involvement in care decision-making may benefit health outcomes. Limited research has examined factors associated adolescents’ the context of advanced disease. Thus, we impact background perceptions on both their desired change involvement. Methods (<60% survival or refractory/relapsed disease), ages 10–23 ( n = 41; M age 15.37), were...
Medication non-adherence rates in children range between 50% and 80% the United States. Due to multifaceted outpatient routines, receiving hematopoietic stem cell transplant (HCT) are at especially high risk of non-adherence, which can be life-threatening. Although digital health interventions have been effective improving many pediatric conditions, limited research has examined their benefits among families HCT. To address this gap, we created BMT4me© mobile app, an innovative intervention...
Veno-occlusive disease (VOD) is a potentially fatal complication of hematopoietic stem cell transplantation (HSCT). Patients with VOD are often critically ill and require close collaboration between transplant physicians intensivists. We surveyed members consortium pediatric intensive care unit (PICU) to assess variability in the self-reported approach diagnosis management VOD. An internet-based self-administered survey was sent HSCT PICU providers from September 2014 February 2015. The...