A5000169183- Ovarian function and disorders
- Reproductive Biology and Fertility
- Reproductive Health and Technologies
- Assisted Reproductive Technology and Twin Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- Prenatal Screening and Diagnostics
- Organ Transplantation Techniques and Outcomes
- Gestational Diabetes Research and Management
- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Reproductive System and Pregnancy
- Gestational Trophoblastic Disease Studies
- T-cell and B-cell Immunology
- Cardiovascular Issues in Pregnancy
- Genetic Syndromes and Imprinting
- Complement system in diseases
- Appendicitis Diagnosis and Management
- Liver Disease Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Systemic Lupus Erythematosus Research
- Hormonal Regulation and Hypertension
- Genomics, phytochemicals, and oxidative stress
- Pregnancy and preeclampsia studies
- Immunotherapy and Immune Responses
- Sexual function and dysfunction studies
University of Pennsylvania
2003-2025
Hospital of the University of Pennsylvania
2017-2025
Eastern Virginia Medical School
2023
University of Pennsylvania Health System
2019-2023
Washington University in St. Louis
2013-2023
Pennsylvania Hospital
2020-2021
Center for Rheumatology
2021
Philadelphia University
2021
Chinese University of Hong Kong
2020
Massachusetts Institute of Technology
2018
Microphysiological systems (MPSs) are in vitro models that capture facets of vivo organ function through use specialized culture microenvironments, including 3D matrices and microperfusion. Here, we report an approach to co-culture multiple different MPSs linked together physiologically on re-useable, open-system microfluidic platforms compatible with the quantitative study a range compounds, lipophilic drugs. We describe three platform designs - "4-way", "7-way", "10-way" each accommodating...
Although certain chemokines and their receptors guide homeostatic recirculation of T cells others promote recruitment activated to inflammatory sites, little is known the mechanisms underlying a third function, migration Foxp3(+) regulatory (T reg) sites where they maintain unresponsiveness. We studied how reg are recruited cardiac allografts in recipients tolerized with CD154 monoclonal antibody (mAb) plus donor-specific transfusion (DST). Real-time polymerase chain reaction showed that...
BackgroundHuman rhinoviruses (HRVs) are the most prevalent human pathogens, and consist of 101 serotypes that classified into groups A B according to sequence variations. HRV infections cause a wide spectrum clinical outcomes ranging from asymptomatic infection severe lower respiratory symptoms. Defining role specific strains in various illnesses has been difficult because traditional serology, which requires viral culture neutralization tests using serotype-specific antisera, is insensitive...
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes global epidemics of debilitating polyarthritis in humans. As there pressing need for the development therapeutic agents, we screened 230 new mouse anti-CHIKV monoclonal antibodies (MAbs) their ability to inhibit infection all three CHIKV genotypes. Four 36 neutralizing MAbs (CHK-102, CHK-152, CHK-166, and CHK-263) provided complete protection against lethality as prophylaxis highly susceptible immunocompromised mice...
Glomerular diseases are classified using a descriptive taxonomy that is not reflective of the heterogeneous underlying molecular drivers. This limits only diagnostic and therapeutic patient management, but also impacts clinical trials evaluating targeted interventions. The Nephrotic Syndrome Study Network (NEPTUNE) poised to address these challenges. study has enrolled >850 pediatric adult patients with proteinuric glomerular who have contributed deep clinical, histologic, genetic, profiles...
Abstract Islet allografts are subject to rapid rejection through host cellular immune responses involving mononuclear cell recruitment and tissue injury. Interruption of leukocyte chemokine receptor targeting is therapeutic benefit in various experimental models, but little known about the contribution pathways islet allograft rejection. We found that murine islets produce monocyte chemoattractant protein-1 (MCP-1; CCL2) vitro was associated with intragraft expression MCP-1 its receptor,...
The mechanisms by which somatic mutations of splicing factors, such as U2AF1 S34F in lung adenocarcinoma, contribute to cancer pathogenesis are not well understood. Here, we used prime editing modify the endogenous gene adenocarcinoma cells and assessed resulting impact on alternative splicing. These analyses identified KRAS a key target modulated . One specific mutation, G12S, generates cryptic binding site that leads skipping exon 2 generation non-functional transcript. Expression mutant...
As rates of bilateral mastectomy and immediate reconstruction rise, the aesthetic psychosocial benefits breast are increasingly well understood. However, an understanding functional outcome its optimization is still lacking. This endpoint critical to maximizing postoperative quality life. All reconstructive modalities have possible consequences. Studies demonstrate that implant-based impacts subjective movement, but patients’ day-to-day function may not be objectively hindered despite...
ObjectiveTo evaluate racial differences in the anxiety and depression prevalence scores women with polycystic ovary syndrome (PCOS).DesignCross-sectional.SettingAcademic institution.Patient(s)Reproductive-aged PCOS (n = 272) controls 295).Intervention(s)Hospital scale modified quality-of-life survey (MPCOS-Q).Main Outcome Measure(s)Differences score measured using hospital MPCOS-Q were determined between White Black PCOS. Multivariable correlation regressions assessed association of...
To identify barriers and facilitators to the implementation of evidence-based guidelines among gynecologists primary care physicians (PCPs) caring for women with polycystic ovary syndrome (PCOS).Qualitative semi-structured interview study.Academic medical center.None.None.Barriers in diagnosis management PCOS.We interviewed 10 8 PCPs reach thematic saturation using a analysis approach. Four themes were identified: diagnostic considerations, treatment symptoms PCOS, screening long-term...
This JAMA Patient Page describes ectopic pregnancy and its risk factors, symptoms, diagnosis, treatment.
Abstract Context Patients with polycystic ovary syndrome (PCOS) are at high risk of depression, anxiety, and metabolic (MetSyn), a key predictor cardiovascular disease. The impact depression and/or anxiety on MetSyn is unknown in this population. Objective To compare the developing patients PCOS without history anxiety. Methods Retrospective longitudinal cohort study (2008-2022) median follow-up 7 years tertiary care ambulatory practice. hyperandrogenic least 2 evaluations for ≥3 apart (n =...
Abstract Context Cross-sectional studies have identified an increased risk of metabolic syndrome (MetSyn) in women with polycystic ovary (PCOS), but longitudinal data are limited and primarily include White European cohorts. Objective To compare the MetSyn Black PCOS to identify potential factors mediating MetSyn. Methods Longitudinal cohort study a follow-up 5.3 years at academic medical center 247 adult hyperandrogenic phenotype 2 or more visits least 3 apart. The main outcome measure was...