A5036530746- Reproductive System and Pregnancy
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Endometriosis Research and Treatment
- Reproductive Health and Technologies
- Assisted Reproductive Technology and Twin Pregnancy
- Treatment of Major Depression
- Ovarian cancer diagnosis and treatment
- Wound Healing and Treatments
- Reproductive Health and Contraception
- Menstrual Health and Disorders
- Gynecological conditions and treatments
- Eating Disorders and Behaviors
- Mesenchymal stem cell research
- Sexual function and dysfunction studies
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Policy and Management
- Cancer survivorship and care
- Diet and metabolism studies
- Tryptophan and brain disorders
- Uterine Myomas and Treatments
- Sperm and Testicular Function
- Intraperitoneal and Appendiceal Malignancies
- Tissue Engineering and Regenerative Medicine
- Endometrial and Cervical Cancer Treatments
Rutgers, The State University of New Jersey
2021-2025
Rutgers New Jersey Medical School
2021-2024
Rutgers Health
2022-2024
University Reproductive Associates
2023-2024
Hackensack University Medical Center
2022-2023
Medical Education Institute
2022-2023
Accreditation Council for Graduate Medical Education
2022-2023
Chongqing Electromechanical Holdings (China)
2022-2023
American Nurses Credentialing Center
2022-2023
Pennsylvania Hospital
2021
The pregnant uterus is an immunologically rich organ, with dynamic changes in the inflammatory milieu and immune cell function underlying key stages of pregnancy. Recent studies have implicated dysregulated expression interleukin-1 (IL-1) family cytokine, IL-33, its receptor, ST2, poor pregnancy outcomes women, including recurrent loss, preeclampsia, preterm labor. How IL-33 supports progression vivo not well understood. Here, we demonstrate that maternal signaling critically regulates...
Abstract STUDY QUESTION How does ovarian stimulation (OS), which is used to mature multiple oocytes for ART procedures, impact the principal cellular compartments and transcriptome of human endometrium in periovulatory mid-secretory phases? SUMMARY ANSWER During window implantation, OS alters abundance endometrial immune cells, whereas during period, substantially changes impacts both glandular cells. WHAT IS KNOWN ALREADY Pregnancies conceived an cycle are at risk complications reflective...
Abstract Follicle-stimulating hormone (FSH) binds to its membrane receptor (FSHR) in granulosa cells activate various signal transduction pathways and drive the gonadotropin-dependent phase of folliculogenesis. Both FSH insufficiency (due genetic or nongenetic factors) excess (as encountered with ovarian stimulation assisted reproductive technology [ART]) can cause poor female outcomes, but underlying molecular mechanisms remain elusive. Herein, we conducted single-follicle single-oocyte RNA...
Abstract At the maternal‐fetal interface, tightly regulated levels of retinoic acid (RA), physiologically active metabolite vitamin A, are required for embryo implantation and pregnancy success. Herein, we utilize mouse models, primary human cells, pharmacological tools to demonstrate how depletion RA signaling via receptor (RAR) disrupts progression early pregnancy. To inhibit RAR during pregnancy, BMS493, an inverse pan‐RAR agonist that prevents RA‐induced differentiation, was administered...
The evaluation of primary amenorrhea requires a thoughtful assessment for hormonal, structural and/or genetic causes. Although most cases are caused by single pathology, rarely multiple pathologies may be uncovered. We present the case 33-year-old woman with history pubertal failure and due to Kallmann syndrome. She reported previous short-term use hormone replacement therapy, onset severe pelvic pain vaginal bleeding following its discontinuation. Her workup revealed concern uterine...
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-aged women. A recent study found that many obstetrics and gynecology (ObGyn) practicing physicians are unaware of Rotterdam criteria recommended for diagnosis. Our objective was to identify gaps trainee knowledge PCOS diagnostic management. An online survey sent out US ObGyn physicians-in-training 2018. The primary outcomes were identification at least one component each (Rot-3): (1)...
ObjectiveTo evaluate racial differences in the anxiety and depression prevalence scores women with polycystic ovary syndrome (PCOS).DesignCross-sectional.SettingAcademic institution.Patient(s)Reproductive-aged PCOS (n = 272) controls 295).Intervention(s)Hospital scale modified quality-of-life survey (MPCOS-Q).Main Outcome Measure(s)Differences score measured using hospital MPCOS-Q were determined between White Black PCOS. Multivariable correlation regressions assessed association of...
Until recently, the study of age-related decline in fertility has focused primarily on ovary; depletion finite pool oocytes and increases meiotic errors leading to oocyte aneuploidy are well-established mechanisms by which declines with advancing age. Comparatively little is known about impact age endometrial function. The endometrium a complex tissue comprised many cell types, including epithelial, stromal, vascular, immune stem cells. capacity this for rapid, cyclic regeneration unique...
Background High attrition rates among African-Americans (AA) volunteers are a persistent problem that makes clinical trials less representative and complicates estimation of treatment outcomes. Many studies contrast AA with other ethnic/racial groups, but few compare the who remain in those leave. Here, addition to comparing patterns between African Americans Whites, we identify predictors overall early Americans. Method Sample comprised non-Hispanic African-American (n = 673) White 2,549)...
In brief Endometrial stromal cell motility is fundamental to regeneration and repair of this tissue crucial for successful reproduction. This paper shows a role the mesenchymal stem (MSC) secretome in enhancing endometrial motility. Abstract Cyclic endometrium are Mesenchymal cells (MSCs) derived from bone marrow (BM-MSC) umbilical cord (UC-MSC) facilitate via their secretome, which contains growth factors cytokines that promote wound healing. Despite implication MSCs repair, mechanisms...
Abstract The gonadotropin-dependent phase of ovarian folliculogenesis primarily requires follicle-stimulating hormone (FSH) to support one or multiple antral follicles, dependent on the species, mature fully, enabling steroidogenesis, oogenesis, and ovulation sustain female reproductive cycles fertility. FSH binds its membrane receptor in granulosa cells activate various signal transduction pathways gene regulatory networks. Poor outcomes can result from both insufficiency owing genetic...
Vessa, Blake MD; Malhotra, Radhika Chemerinski, Anat Howard, David MD, PhD; Morelli, Sara PhD Author Information
In the setting of a known ectopic pregnancy, severe abdominal pain with clinical concern for rupture is an indication emergency surgery. rare cases, appendiceal pathology may occur simultaneously.A woman pregnancy presented to department picture consistent its rupture. At time surgery, appendectomy also was performed owing concurrent appendicitis; histopathologic examination revealed endometriosis.During surgical management it important undertake thorough pelvis, because patients present...
Dr. Chafitz is a Resident, Department of Obstetrics and Gynecology, Hackensack University Medical Center, Hackensack, NJ 07601, E-mail: [email protected]; Chemerinski Reproductive Endocrinology Infertility Fellow, Rutgers-New Jersey School, Newark, New Jersey; McGovern Associate Professor, Jersey, Associates, Hasbrouck Heights, Jersey. All authors, faculty, staff have no relevant financial relationships with any ineligible organizations regarding this educational activity. CME Accreditation...
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting reproductive aged women. The prevalence of comorbidities associated with PCOS vary phenotype and race. An increased risk moderate severe depressive anxiety symptoms has been reported in this group. Racial differences mood disorders described general population are influenced by factors such as obesity socioeconomic status (SES). We aimed to determine depression, decreased quality life between black white women...