A5021603798- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Pregnancy and preeclampsia studies
- Chemotherapy-induced organ toxicity mitigation
- Cancer Treatment and Pharmacology
- IL-33, ST2, and ILC Pathways
- Adenosine and Purinergic Signaling
- Pain Mechanisms and Treatments
- Estrogen and related hormone effects
- Cancer, Stress, Anesthesia, and Immune Response
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cancer-related gene regulation
- Kruppel-like factors research
Michigan State University
2022-2025
Institute of Molecular and Cell Biology
2023
The pregnant uterus is an immunologically rich organ, with dynamic changes in the inflammatory milieu and immune cell function underlying key stages of pregnancy. Recent studies have implicated dysregulated expression interleukin-1 (IL-1) family cytokine, IL-33, its receptor, ST2, poor pregnancy outcomes women, including recurrent loss, preeclampsia, preterm labor. How IL-33 supports progression vivo not well understood. Here, we demonstrate that maternal signaling critically regulates...
Abstract At the maternal‐fetal interface, tightly regulated levels of retinoic acid (RA), physiologically active metabolite vitamin A, are required for embryo implantation and pregnancy success. Herein, we utilize mouse models, primary human cells, pharmacological tools to demonstrate how depletion RA signaling via receptor (RAR) disrupts progression early pregnancy. To inhibit RAR during pregnancy, BMS493, an inverse pan‐RAR agonist that prevents RA‐induced differentiation, was administered...
Use of non-steroidal anti-inflammatory drugs that target prostaglandin synthase (PTGS) enzymes have been implicated in miscarriage. Further, PTGS2-derived prostaglandins are reduced the endometrium patients with a history implantation failure. However, mouse model pregnancy, peri-implantation PTGS2 function is controversial. Some studies suggest Ptgs2-/- mice display deficits ovulation, fertilization, and implantation, while other role for only ovulation but not implantation. uterine cell...
Cisplatin is a potent chemotherapeutic drug that widely used in the treatment of various solid cancers. However, its clinical effectiveness strongly limited by frequent severe adverse effects, particular nephrotoxicity and chemotherapy-induced peripheral neuropathy. Thus, there an urgent medical need to identify novel strategies limit cisplatin-induced toxicity. In present study, we show FDA-approved adenosine A2A receptor antagonist istradefylline (KW6002) protected from neuropathic pain...
BACKGROUND: Pain is one of the first presenting symptoms in patients with head and neck cancer, who often develop chronic debilitating pain as disease progresses. also an important prognostic marker for survival. Unfortunately, rarely receive effective treatment due to our limited knowledge mechanisms underlying cancer (HNCP). associated neuroinflammation particularly interleukin (IL)-1 signaling. The purpose this study a novel syngeneic model HNCP immunocompetent mice examine contribution...
Abstract Endometrial stromal cell decidualization is required for pregnancy success. Although this process integral to fertility, many of the intricate molecular mechanisms contributing remain undefined. One pathway that has been implicated in endometrial humans vitro Hippo signaling pathway. Two previously conducted studies showed effectors pathway, YAP1 and WWTR1, were primary cells culture. To investigate vivo role WWTR1 initiation, we generated a Progesterone Cre mediated partial double...
ABSTRACT Use of non-steroidal anti-inflammatory drugs that target prostaglandin synthase (PTGS) enzymes have been implicated in miscarriage. Further, PTGS2-derived prostaglandins are reduced the endometrium patients with a history implantation failure. However, mouse model pregnancy, peri-implantation PTGS2 function is controversial. Some studies suggest Ptgs2 -/- mice display deficits ovulation, fertilization, and implantation, while other role for only ovulation but not implantation....
Endometrial stromal cell decidualization is required for pregnancy success. Although this process integral to fertility, many of the intricate molecular mechanisms contributing remain undefined. One pathway that has been implicated in endometrial humans vitro, Hippo signaling pathway. Two previously conducted studies showed effectors pathway, YAP1 and WWTR1, are primary cells vitro. To investigate vivo role WWTR1 initiation, we generated Progesterone receptor Cre mediated mutation a...