A5008946090- melanin and skin pigmentation
- Nanoplatforms for cancer theranostics
- Neonatal Respiratory Health Research
- Telomeres, Telomerase, and Senescence
- Radiation Therapy and Dosimetry
- Skin Protection and Aging
- Galectins and Cancer Biology
- DNA Repair Mechanisms
- Effects of Radiation Exposure
- Pancreatic and Hepatic Oncology Research
- Birth, Development, and Health
- Signaling Pathways in Disease
- Brain Metastases and Treatment
- Extracellular vesicles in disease
- Anesthesia and Neurotoxicity Research
- Carcinogens and Genotoxicity Assessment
- Cancer Research and Treatments
- Prostate Cancer Treatment and Research
- Xenotransplantation and immune response
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Treatment and Pharmacology
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
Centre Hospitalier Universitaire de Lille
2022-2024
Université de Lille
2022-2024
Inserm
2020-2024
Centre National de la Recherche Scientifique
2020-2024
Institut Pasteur de Lille
2020-2024
CANTHER - Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers
2020-2022
Institut de Biologie de Lille
2020
Often discovered at an advanced stage, ovarian cancer progresses to peritoneal carcinoma, which corresponds the invasion of serosa by multiple tumor implants. The current treatment is based on combination chemotherapy and cytoreduction surgery. Despite progress standardization surgical techniques combined with effective chemotherapy, post-treatment recurrences affect more than 60% women in remission. Photodynamic therapy (PDT) has been particularly indicated for superficial lesions large...
A rare but severe complication of curative-intent radiation therapy is the induction second primary cancers. These cancers preferentially develop not inside planning target volume (PTV) around, over several centimeters, after a latency period 1-40 years. We show here that normal human or mouse dermal fibroblasts submitted to out-of-field dose scattering at margin PTV receiving mimicked patient's treatment do die enter in long-lived senescent state resulting from accumulation unrepaired DNA...
To date, pancreatic adenocarcinoma (ADKP) is a devastating disease for which the incidence rate close to mortality rate. The survival has evolved only 2–5% in 45 years, highlighting failure of current therapies. Otherwise, use photodynamic therapy (PDT), based on an adapted photosensitizer (PS) already proved its worth and prompted growing interest field oncology. We have developed new (PS-FOL/PS2), protected by recently published patent (WO2019 016397-A1, 24 January 2019). This associated...
Cisplatin is a potent chemotherapeutic drug that widely used in the treatment of various solid cancers. However, its clinical effectiveness strongly limited by frequent severe adverse effects, particular nephrotoxicity and chemotherapy-induced peripheral neuropathy. Thus, there an urgent medical need to identify novel strategies limit cisplatin-induced toxicity. In present study, we show FDA-approved adenosine A2A receptor antagonist istradefylline (KW6002) protected from neuropathic pain...
// Marion Dubuissez 1 , 5 * Sonia Paget Souhila Abdelfettah Nathalie Spruyt Vanessa Dehennaut Gaylor Boulay 2 Ingrid Loison Clementine de Schutter Brian R. Rood 3 Martine Duterque-Coquillaud Xavier Leroy 4 and Dominique Leprince University Lille, CNRS, INSERM, Institut Pasteur UMR9020-UMR-S1277 - Canther Cancer Heterogeneity, Plasticity Resistance to Therapies, France Department of Pathology Center for Research, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA...
Aging | doi:10.18632/aging.206149. Elise Srour, Nathalie Martin, Claire Drullion, Clémentine De Schutter, Joëlle Giroud, Adrien Pioger, Julie Deslé, Laure Saas, Joe Nassour, Julien Théry, Gauthier Decanter, Nicolas Penel, Chantal Vercamer, Clara Salazar-Cardozo, Corinne Abbadie, Olivier Pluquet
ABSTRACT Introduction and main objectives Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive irreversible interstitial lung disease (ILD), that increases dramatically in incidence prevalence with age. While successful alveolar regeneration after injury depends on capillary endothelial cells (PCEC) reprogramming, the steps involving PCEC during resolution as well influence of aging are unknown. Methods We used single-cell RNA-seq (scRNA-seq) spatial transcriptomics to compare...