A5011564773- Galectins and Cancer Biology
- Cancer Immunotherapy and Biomarkers
- Head and Neck Cancer Studies
- Extracellular vesicles in disease
- Toxin Mechanisms and Immunotoxins
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Single-cell and spatial transcriptomics
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Photoacoustic and Ultrasonic Imaging
- Radiomics and Machine Learning in Medical Imaging
- Immunotherapy and Immune Responses
- Plant Virus Research Studies
- interferon and immune responses
- Infant Nutrition and Health
- Nanoplatforms for cancer theranostics
- Metabolism, Diabetes, and Cancer
- Optical Imaging and Spectroscopy Techniques
- Ultrasound Imaging and Elastography
- Intracerebral and Subarachnoid Hemorrhage Research
- Colorectal and Anal Carcinomas
- Lymphoma Diagnosis and Treatment
King's College London
2020-2025
Inserm
2023
Université de Lille
2014-2023
Centre Hospitalier Universitaire de Lille
2023
Cancer Research UK
2020-2021
Kings Health Partners
2020-2021
OncoThAI
2019
Centre National de la Recherche Scientifique
2014-2018
Institut de Biologie de Lille
2014-2018
Institut Pasteur de Lille
2014-2015
Regulatory T cells (Treg) and tumor-exosomes are thought to play a role in preventing the rejection of malignant patients bearing nasopharyngeal carcinoma (NPC). Treg recruitment by exosomes derived from NPC cell lines (C15/C17-Exo), isolated patients' plasma (Patient-Exo), CCL20 were tested vitro using Boyden chamber assays vivo xenograft SCID mouse model (n = 5), both presence absence anti-CCL20 monoclonal antibodies (mAb). Impact these (NPC-Exo) on phenotype function was determined...
Summary Epstein–Barr Virus ( EBV ) is present in the neoplastic cells of around 20–30% patients with Hodgkin Lymphoma HL ). Although, an immunosuppressive environment currently described patients, little known concerning regulatory mechanism induced by proteins expression tumour cells. This study aimed to investigate association between Type 1 (Tr1) and tissue positivity patients. Transcriptomic analysis both ‐positive ‐negative tumours showed that infection increased gene Tr1‐related...
Tumor-associated macrophages (TAMs) can exist in pro- and anti-inflammatory states. Anti-inflammatory TAMs (also referred to as M2-polarized) generally suppress antitumor immune responses enhance the metastatic progression of cancer. To explore mechanisms behind this phenomenon, we isolated from mice humans, polarized them ex vivo, examined their functional interaction with breast cancer cells culture mice. We found that promoted a metabolic state supported various protumorigenic phenotypes....
Abstract Background Lung cancer is the leading cause of cancer-related deaths. Diagnosis at late stages common due to largely non-specific nature presenting symptoms contributing high mortality. There a lack specific, minimally invasive low-cost tests screen patients ahead diagnostic biopsy. Patients and Methods 344 symptomatic from lung clinic Lister hospital suspected were recruited. Predictive covariates successfully generated on 170 Computed Tomography (CT) scans using CT Texture...
Over the past decade, immunotherapy delivered novel treatments for many cancer types. However, lung still leads mortality, and non-small-cell carcinoma patients with mutant EGFR cannot benefit from checkpoint inhibitors due to toxicity, relying only on palliative chemotherapy third-generation tyrosine kinase inhibitor (TKI) osimertinib. This new drug extends lifespan by 9-months vs. second-generation TKIs, but unfortunately, cancers relapse resistance mechanisms lack of antitumor immune...
Abstract Glioblastoma is the most common and aggressive primary malignant brain tumor with poor prognosis. Novel immunotherapeutic approaches are currently under investigation. Even though magnetic resonance imaging (MRI) important tool for treatment monitoring, response assessment often hampered by therapy-related tissue changes. As therapy-associated reactions differ structurally, we hypothesize that biomechanics could be a pertinent proxy differentiation. Longitudinal MRI elastography...
To date, pancreatic adenocarcinoma (ADKP) is a devastating disease for which the incidence rate close to mortality rate. The survival has evolved only 2–5% in 45 years, highlighting failure of current therapies. Otherwise, use photodynamic therapy (PDT), based on an adapted photosensitizer (PS) already proved its worth and prompted growing interest field oncology. We have developed new (PS-FOL/PS2), protected by recently published patent (WO2019 016397-A1, 24 January 2019). This associated...
Background Pancreatic adenocarcinoma (PDAC) is a devastating disease with an urgent need for therapeutic innovation. Immune checkpoint inhibition has shown promise in variety of solid tumors, but most clinical trials have failed to demonstrate efficacy PDAC. This low partly explained by highly immunosuppressive microenvironment, which dampens anti-tumor immunity through the recruitment or induction cells, particularly regulatory T cells (Tregs). In this context, our laboratory developed...
The physics of shear waves traveling through matter carries fundamental insights into its structure, for instance, quantifying stiffness disease characterization. However, the origin wave attenuation in tissue is currently not properly understood. Attenuation caused by two phenomena: absorption due to energy dissipation and scattering on structures such as vessels fundamentally tied material’s microstructure. Here, we present a theory conjunction with magnetic resonance imaging, which...
Organoids have been successfully used in several areas of cancer research and large living biobanks patient-derived organoids (PDOs) developed from various malignancies. The characteristics the original tumour tissue such as mutation signatures, phenotype genetic diversity are well preserved organoids, thus showing promising results for use this model translational research. In study, we aim to assess whether can generate PDOs head neck squamous cell carcinoma (HNSCC) samples be predict...
Extra-cellular galectin-9 (gal-9) is an immuno-modulatory protein with predominant immunosuppressive effects. Inappropriate production of gal-9 has been reported in several human malignancies and viral diseases like nasopharyngeal, pancreatic renal carcinomas, metastatic melanomas chronic active hepatitis. Therefore therapeutic antibodies neutralizing extra-cellular are expected to contribute immune restoration these pathological conditions. Two novel monoclonal targeting –Gal-Nab 1 2—have...
Background: Advanced head and neck squamous cell carcinoma (HNSCC) is associated with a poor prognosis, biomarkers that predict response to treatment are highly desirable. The primary aim was progression-free survival (PFS) multivariate risk prediction model. Methods: Experimental covariates were derived from blood samples of 56 HNSCC patients which prospectively obtained within Phase 2 clinical trial (NCT02633800) at baseline after the first cycle combined platinum-based chemotherapy...
TPS6128 Background: Head and Neck Squamous Cell Carcinoma (HNSCC) is the 7 th most common cancer worldwide with more than 660,000 cases diagnosed annually. Many patients present locally advanced disease, which despite aggressive multi-modality treatment remains associated poor survival. Approximately 50% of relapse within 2 years, mostly occurring in first year after treatment. Biomarkers predicting are lacking there no consensus on surveillance, strategies differing according to local...
MRI and MRE were used to monitor the effects of immunotherapy on tumor volume, FA biomechanics murine orthotopic glioma. Treated tumors significantly smaller, softer had lower than controls. This difference was most pronounced when comparing stiffness both groups. Controls revealed heterogeneous stiffness. We hypothesize that this is caused by viable cells alternated with necrotic areas presumably immune-suppressive iba1-positive cells. In contrast, biomechanical properties treated animals...
Abstract Background: In advanced head and neck squamous cell carcinoma (HNSCC), immune checkpoint inhibitors are only effective in 15-20% of cases. Defects replication stress response represent a promising avenue for enhancing the therapeutic efficacy immunotherapy through DNA damage release immunostimulatory DNA. MUS81, structure-specific endonuclease involved resolving stress, is upregulated many cancer types including HNSCC, MUS81-associated cytosolic implicated triggering cGAS-STING...
ABSTRACT We propose a novel pipeline for the analysis of imaging mass cytometry data, comparing an unbiased approach, representing actual gold standard, with biased method. made use both synthetic/ controlled datasets as well two obtained from FFPE sections follicular lymphoma, and head neck patients, stained 14 29-markers panels respectively. The pipeline, denominated RUNIMC, has been completely developed in R contained single package. novelty resides ease which multi-class random forest...
A localized area of calcified, fibrotic, and aneurysmally enlarged terminal branches one middle cerebral artery with radiologically demonstrable calcification in the arterial walls was found coincidentally at autopsy. This unique lesion appears to be end result a healed arteritis, possibly embolic nature. Such lesions could cause considerable difficulty clinical diagnosis if an x-ray examination skull.
Abstract IMMUcan is a joint public-private partnership to advance our understanding of how tumors and the immune system interact effect therapeutic interventions. The project will collect tumor biopsies peripheral blood from up 3,000 patients across 13 European countries for multi-omic analyses. Here, we assessed impact sample collection processing conditions on quality mononuclear cells (PBMCs). We also compared circulating exosomes obtained plasma serum determine ideal source study....