A5044691926- Ultrasound Imaging and Elastography
- Advanced MRI Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Elasticity and Material Modeling
- Cardiovascular Function and Risk Factors
- MRI in cancer diagnosis
- Liver Disease Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Cardiac Imaging and Diagnostics
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Disease and Adiposity
- Cardiac Arrhythmias and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Photoacoustic and Ultrasonic Imaging
- Infection Control and Ventilation
- Cardiovascular Syncope and Autonomic Disorders
- Cellular Mechanics and Interactions
- Atrial Fibrillation Management and Outcomes
- Pancreatitis Pathology and Treatment
- Cardiac electrophysiology and arrhythmias
- Electrical and Bioimpedance Tomography
- Bone health and osteoporosis research
- Aerosol Filtration and Electrostatic Precipitation
- Atomic and Subatomic Physics Research
- Orthopaedic implants and arthroplasty
King's College London
2020-2025
Siemens Healthcare (Germany)
2023-2025
King Hussein Cancer Center
2024
Siemens (United Kingdom)
2023-2024
Inserm
2023
Laboratoire de Recherche Vasculaire Translationnelle
2023
Université Paris Cité
2023
Délégation Paris 7
2023
Assessment of tumor biomechanics through MR elastography improved the identification complete responders among individuals with breast cancer undergoing neoadjuvant chemotherapy.
Three-dimensional (3D) magnetic resonance elastography (MRE) measures liver fibrosis and inflammation but requires several breath-holds that hamper clinical acceptance. The aim of this study was to evaluate the technical feasibility a single breath-hold 3D MRE sequence as means measuring in obese patients.From November 2020 December 2021, subjects were prospectively enrolled divided into 2 groups. Group 1 included healthy volunteers (n = 10) who served controls compare with...
To explore the optimal choice of seven diffusion models (DWI, IVIM, DKI, CTRW, FROC, SEM, and sADC) to assess renal interstitial fibrosis (IF) annual function loss in chronic kidney disease (CKD). One hundred thirty-three CKD patients 30 controls underwent multi-b sequence scans. Patients were divided into training, testing, temporal external validation sets. Least absolute shrinkage selection operator regression logistic used select metrics for distinguishing mild from moderate-to-severe...
Changes in brain stiffness can be an important biomarker for neurological disease. Magnetic resonance elastography (MRE) quantifies tissue stiffness, but the results vary between acquisition and reconstruction methods.To measure MRE repeatability estimate effect of different methods varying data quality on estimated stiffness.Prospective.Fifteen healthy subjects.3T MRI, gradient-echo sequence with a 50 Hz vibration frequency.Imaging was performed twice each subject. Images were reconstructed...
Understanding how mechanical properties relate to functional changes in glioblastomas may help explain different treatment response between patients. The aim of this study was map differences biomechanical and tumor healthy tissue, assess any relationship them their spatial distribution. Ten patients with glioblastoma 17 subjects were scanned using MR Elastography, perfusion diffusion MRI. Stiffness viscosity measurements G' G'', cerebral blood flow (CBF), apparent coefficient (ADC)...
Magnetic resonance elastography (MRE) can quantify tissue biomechanics noninvasively, including pathological hepatic states like metabolic dysfunction-associated steatohepatitis.
To demonstrate the feasibility of hepatic 3D MR elastography (MRE) at 0.55 T in healthy volunteers using Hadamard encoding and to study effects concomitant fields domain MRE general. Concomitant field are assessed a Taylor series expansion an scheme is proposed corresponding on numerical simulations phantom experiments. In addition, five were enrolled scanned 60 Hz mechanical excitation with Hadamard-encoded sequence also reference 3 for comparison. The retrieved biomechanical parameters...
Atrial fibrillation (AF) diminishes left atrial (LA) mechanical function and impairs blood flow.The latter can lead to stasis increased risk of thrombus formation stroke.We investigate this by studying the effects LA flow in sinus rhythm (SR) AF on coagulation dynamics.Patient-specific computational fluid dynamics (CFD) simulations were coupled with reaction-diffusionconvection equation for thrombin.Patient wall motions driving reconstructed from Cine MRI data during SR AF. 15 cardiac cycles...
Introduction: Magnetic resonance elastography (MRE) is a non-invasive method to quantify biomechanical properties of human tissues. It has potential in diagnosis and monitoring kidney disease, if established clinical practice. The interplay flow volume changes renal vessels, tubule, urinary collection system interstitium complex, but physiological ranges vivo viscoelastic during fasting hydration have never been investigated all gross anatomical segments simultaneously. Method: Ten healthy...
The physics of shear waves traveling through matter carries fundamental insights into its structure, for instance, quantifying stiffness disease characterization. However, the origin wave attenuation in tissue is currently not properly understood. Attenuation caused by two phenomena: absorption due to energy dissipation and scattering on structures such as vessels fundamentally tied material’s microstructure. Here, we present a theory conjunction with magnetic resonance imaging, which...
Motivation: Expanding hepatic 3D MRE to wide-bore low field MR systems (B0 ≤ 1.0T) can serve as a means of accommodating liver patients with high BMI and/or claustrophobia such metabolic dysfunction-associated fatty disease (MAFLD) patients. Goal(s): Demonstrate the feasibility at 0.55T in healthy volunteers. Approach: 5 volunteers were scanned 60Hz mechanical excitation Hadamard-encoded sequence and also reference 3T for comparison. Results: Bland-Altman analysis demonstrated good...
Motivation: Most current volumetric 3D MRE sequences are restricted to 2D slice acquisitions, but we propose a novel sequence for rapid slab-selective MRE. Goal(s): To demonstrate the feasilbility of with an interleaved motion encoding scheme. Approach: The proposed allows measurement different wave offsets and encodings slab in single constant repetition time, minimising total acquisition time. Results: We show initial results technique phantom breathhold liver healthy subject. Impact:...
Motivation: To our knowledge, concomitant field effects in MRE have not been investigated yet, which might become of importance when translating to low MR systems. Goal(s): Propose a framework investigate on MRE, particular Hadamard-encoded 3D at 0.55T. Approach: A 6x6 encoding scheme is proposed study the fields 0.55T phantom experiments. Results: Phantom experiments demonstrated that are negligible. Impact: assess
The reciprocal interaction between cancer cells and the surrounding creates a tumorigenic feedback loop capable of shifting anti-neoplastic feature microenvironment towards tumour growth-promoting one. Unfortunately infiltrating tumours, like GBMs, do not have discrete boundaries intra-axial metastases are visible on conventional MR images. However they expected to change tissue biomechanics. Here we explored biomechanics non-invasively using MRE in cohort 23 patients with brain tumours - 13...
Motivation: To achieve de-escalation of surgery in breast cancer patients having complete response after primary chemotherapy, we require better accuracy than the current gold standard DCE-MRI, which has a sensitivity 80-90% and specificity 37-97%. Goal(s): Investigate diagnostic value biomechanical imaging biomarkers quantified via MR-Elastography (MRE) for gauging pathological non-invasively. Approach: Incorporate MRE into Breast MRI protocol NACT within standard-of-care protocol. Results:...
Motivation: We want contribute to establish MR Elastography as a reliable imaging technique for liver characterization. Goal(s): To validate the repeatability and reproducibility of novel, gravitational hepatic MRE system using generalized multi-shot GRE-MRE sequence. Approach: 57 health volunteers underwent 2D 3D scans on 3T Siemens scanner. The was evaluated through repeated volunteer without repositioning, while performed by re-positioning after each acquisition. Results: coefficients...
Abstract PURPOSE Understanding how mechanical properties relate to functional changes in glioblastomas may help explain different treatment response between patients. The aim of this study was map differences biomechanical and tumor healthy tissue, assess any relationship them their spatial distribution. METHODS Ten patients with glioblastoma 17 subjects were scanned using MR Elastography, perfusion diffusion MRI. Stiffness viscosity measurements G′ G′′, cerebral blood flow (CBF), apparent...
Distinctive traits of malignant tumours are abnormal angiogenesis and high pressure. Conventional magnetic resonance imaging (MRI) plays a critical role in radiological evaluation patients tumour grading, but challenges remain. Pressure vasculature have strong impact on the tissue rheology therefore they can be quantified by Magnetic Resonance Elastography (MRE). We show that MRE allows to quantify non-invasively grade using pressure through wave scattering. believe could play central...