A5046728171- Immune Cell Function and Interaction
- Melanoma and MAPK Pathways
- Gut microbiota and health
- Immunotherapy and Immune Responses
- Neonatal Respiratory Health Research
- IL-33, ST2, and ILC Pathways
- Antimicrobial Peptides and Activities
- Virus-based gene therapy research
- Veterinary Oncology Research
- Nail Diseases and Treatments
- Probiotics and Fermented Foods
- Extracellular vesicles in disease
- Congenital Diaphragmatic Hernia Studies
- Bladder and Urothelial Cancer Treatments
- Clostridium difficile and Clostridium perfringens research
- Cancer Immunotherapy and Biomarkers
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Dietary Effects on Health
- Cellular Mechanics and Interactions
- Cell Adhesion Molecules Research
- Studies on Chitinases and Chitosanases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Mechanisms and Therapy
- Dupuytren's Contracture and Treatments
- Cutaneous Melanoma Detection and Management
University of Milano-Bicocca
2017-2024
Centre National de la Recherche Scientifique
2020-2023
Université Côte d'Azur
2020-2023
Institut de Pharmacologie Moléculaire et Cellulaire
2020-2022
The interaction between the gut microbiota and invariant Natural Killer T (iNKT) cells plays a pivotal role in colorectal cancer (CRC). pathobiont Fusobacterium nucleatum influences anti-tumor functions of CRC-infiltrating iNKT cells. However, impact other bacteria associated with CRC, like Porphyromonas gingivalis, on their activation status remains unexplored. In this study, we demonstrate that mucosa-associated P. gingivalis induces protumour phenotype cells, subsequently influencing...
Article14 February 2022Open Access Source DataTransparent process Blockade of the pro-fibrotic reaction mediated by miR-143/-145 cluster enhances responses to targeted therapy in melanoma Serena Diazzi Université Côte d'Azur, INSERM, C3M, Nice, France CNRS, Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), Sophia Antipolis, Equipe labellisée Ligue Contre le Cancer, Contribution: Conceptualization, Formal analysis, Investigation, Methodology, Writing - original draft, review &...
iNKT cells account for a relevant fraction of effector T-cells in the intestine and are considered an attractive platform cancer immunotherapy. Although cytotoxic lymphocytes, their functional role colorectal (CRC) is still controversial, limiting therapeutic use. Thus, we examined immune cell composition phenotype CRC lesions patients (n = 118) different murine models. High-dimensional single-cell flow-cytometry, metagenomics, RNA sequencing experiments revealed that enriched tumor lesions....
The human gut is a complex environment where the microbiota and its metabolites play crucial role in maintenance of healthy state. aim present work reconstruction new vitro minimal resembling microbe-microbe networking comprising principal phyla (Bacillota, Bacteroidota, Pseudomonadota, Actinomycetota), to comprehend intestinal ecosystem complexity. In reductionist model, we mimicked administration Maitake extract as prebiotic probiotic formulation (three strains belonging Lactobacillus...
Colorectal cancer (CRC) is a multifaceted disease whose development and progression varies depending on tumor location, age of patients, infiltration immune cells within lesions, the microenvironment. These pathophysiological characteristics are additionally influenced by sex-related differences. The gut microbiome plays role in initiation CRC, shapes anti-tumor responses but how responsiveness system to intestinal microbiota may contribute sexual dimorphism CRC largely unknown. We studied...
The crested porcupine Hystrix cristata is the largest rodent in Italy; it strictly protected according to national and international laws. Despite this, porcupines Italy are still poached for meat complained crop damages. species almost exclusively nocturnal quite elusive. Its presence may be yet recorded through detection of quills lost on ground. In last 40 years, showed a remarkable range expansion Italy. 2013, framework www.naturaesocialmapping.it recording site, web page devoted H. was...
Mammary carcinoma, including triple-negative breast carcinomas (TNBC) are tumor-types for which human and canine pathologies closely related at the molecular level. The efficacy of an oncolytic vaccinia virus (VV) was compared in low-passage primary carcinoma cells from TNBC versus non-TNBC. Non-TNBC were 28 fold more sensitive to VV than replication is impaired. Single-cell RNA-seq performed on two different cell samples, infected or not with VV, highlighted three distinct populations:...
Colorectal cancer (CRC) is a multifaceted disease whose development and progression varies depending on tumor location, age of patients, infiltration immune cells within lesions, the microenvironment. These pathophysiological characteristics are additionally influenced by sex-related differences. The gut microbiome plays pivotal role in initiation CRC, shapes anti-tumor responses but how responsiveness system to intestinal microbiota may contribute sexual dimorphism CRC largely unknown....
The interaction between the gut microbiota and invariant Natural Killer T (iNKT) cells plays a pivotal role in colorectal cancer (CRC). Porphyromonas gingivalis is keystone oral pathogen associated with CRC. pathobiont Fusobacterium nucleatum influences anti-tumour functions of CRC-infiltrating iNKT cells. However, impact other bacteria, like P. gingivalis, on their activation status remains unexplored. In this study, we demonstrate that mucosa-associated induces protumour phenotype cells,...
Dupuytren disease (DD) is a hand-localized fibrotic disorder characterized by scar-like, collagen-rich cord. Treatment usually comprises surgical removal of the cord, but associated with high relapse rate, in some cases requiring finger amputation. There currently no consensual medical approach for treating DD. Numerous preclinical studies have highlighted antifibrotic properties metformin, and aim this study was to assess potential role metformin Fibroblasts from DD cords (DF)...
ABSTRACT Introduction and main objectives Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive irreversible interstitial lung disease (ILD), that increases dramatically in incidence prevalence with age. While successful alveolar regeneration after injury depends on capillary endothelial cells (PCEC) reprogramming, the steps involving PCEC during resolution as well influence of aging are unknown. Methods We used single-cell RNA-seq (scRNA-seq) spatial transcriptomics to compare...
Abstract Mammary carcinoma, including triple-negative breast carcinomas (TNBC) are tumor-types for which human and canine pathologies closely related at the molecular level. Low-passage, primary carcinoma cells from TNBC versus non-TNBC were used to compare efficacy of an oncolytic vaccinia virus (VV). We show that 28 times more sensitive VV than in replication is impaired. Single-cell RNA-seq performed on two different cell samples infected or not with highlighted three distinct...
Abstract Lineage dedifferentiation towards a mesenchymal-like state is common mechanism of adaptive response and resistance to targeted therapy in melanoma. Yet, the transcriptional network driving this phenotypic plasticity remains elusive. Remarkably, cellular displays myofibroblast fibrotic features escapes MAPK inhibitors (MAPKi) through extracellular matrix (ECM) remodeling activities. Here we show that anti-fibrotic drug Nintedanib/BIBF1120 active normalize fibrous ECM network, enhance...