A5041598590- Melanoma and MAPK Pathways
- Cutaneous Melanoma Detection and Management
- Pregnancy and preeclampsia studies
- Cellular Mechanics and Interactions
- Gestational Diabetes Research and Management
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Birth, Development, and Health
- Cell Adhesion Molecules Research
- Silk-based biomaterials and applications
- Infant Development and Preterm Care
Inserm
2021-2025
Université Paris Cité
2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2025
Centre de Recherche Épidémiologie et Statistique
2025
Maternité Port Royal
2025
Assistance Publique – Hôpitaux de Paris
2025
Université Côte d'Azur
2021
La Ligue Contre le Cancer
2021
Abstract Objective Extremes of prepregnancy maternal BMI increase neonatal mortality and morbidity at term. They also the risk extremely preterm (EP, i.e., <27 weeks' gestational age) births. However, association between outcomes for EP babies is poorly understood. Methods We used a cross‐country design, bringing together following three population‐based, prospective, national birth cohorts: EXPRESS (Sweden, 2004–2007); EPICure 2 (UK, 2006); EPIPAGE (France, 2011). included all singleton...
Background Before 26 weeks of gestational age, because extremely preterm infants (EPI) face a high risk death or disability, management decisions may involve either active treatment palliative care. Survival chances largely depend on the willingness medical teams and parents to opt for management. Variability practices explains differences in survival between countries regions, interpersonal variability also exist among caregivers within same center. Our objective was study their...
Abstract Lineage dedifferentiation towards a mesenchymal-like state is common mechanism of adaptive response and resistance to targeted therapy in melanoma. Yet, the transcriptional network driving this phenotypic plasticity remains elusive. Remarkably, cellular displays myofibroblast fibrotic features escapes MAPK inhibitors (MAPKi) through extracellular matrix (ECM) remodeling activities. Here we show that anti-fibrotic drug Nintedanib/BIBF1120 active normalize fibrous ECM network, enhance...