A5089482537- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Infant Nutrition and Health
- Birth, Development, and Health
- Retinopathy of Prematurity Studies
- Neuroscience of respiration and sleep
- Child Nutrition and Water Access
- Congenital Diaphragmatic Hernia Studies
- Child and Adolescent Health
- Breastfeeding Practices and Influences
- Global Maternal and Child Health
- Preterm Birth and Chorioamnionitis
- Cerebral Palsy and Movement Disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Obesity, Physical Activity, Diet
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Language Development and Disorders
- Child Nutrition and Feeding Issues
- Congenital Heart Disease Studies
- Food Security and Health in Diverse Populations
- Gestational Diabetes Research and Management
- Neonatal and Maternal Infections
- Pregnancy and preeclampsia studies
- Congenital Anomalies and Fetal Surgery
Uppsala University
2015-2025
Umeå University
2007-2023
Karolinska Institutet
1994-2019
Stockholm County Council
2019
Stockholm South General Hospital
2019
Region Jönköpings län
2019
Sachs' Children and Youth Hospital
2019
Karolinska University Hospital
2019
Uppsala University Hospital
1998-2018
Pediatrics and Genetics
2007-2017
Context Up-to-date information on infant survival after extremely preterm birth is needed for assessing perinatal care services, clinical guidelines, and parental counseling.Objective To determine the 1-year in all infants born before 27 gestational weeks Sweden during 2004-2007. Design, Setting, PatientsPopulation-based prospective observational study of (707 live-born 304 stillbirths) to 887 mothers 904 deliveries (102 multiple births) obstetric neonatal units from April 1, 2004, March 31,...
<h3>Importance</h3>Active perinatal care increases survival of extremely preterm infants; however, improved might be associated with increased disability among survivors.<h3>Objective</h3>To determine neurodevelopmental outcome in children at 2.5 years (corrected age).<h3>Design, Setting, and Participants</h3>Population-based prospective cohort consecutive infants born before 27 weeks gestation Sweden between 2004 2007. Of 707 live-born infants, 491 (69%) survived to years. Survivors were...
Active perinatal care increases the rate of survival extremely preterm infants, but there are concerns that improved might increase disabled survivors.To determine neurodevelopmental outcomes a national cohort children 6.5 years age who had been born (<27 weeks' gestational age) in Sweden.Population-based prospective study consecutively infants. All these infants were Sweden during period from April 1, 2004, to March 31, 2007. Of 707 live-born 486 (68.7%) survived age. These assessed and...
Importance Since 2004-2007, national guidelines and recommendations have been developed for the management of extremely preterm births in Sweden. If how more uniform has affected infant survival is unknown. Objective To compare infants born during 2004-2007 with 2014-2016. Design, Setting Participants All at 22-26 weeks’ gestational age (n = 2205) between April 1, 2004, March 31, 2007, January 2014, December 2016, Sweden were studied. Prospective data collection was used 2004-2007. Data...
The aim of this study was to determine the incidence neonatal morbidity in extremely preterm infants and identify associated risk factors.Population based born before 27 gestational weeks admitted for intensive care Sweden during 2004-2007.Of 638 infants, 141 died. Among these, life support withdrawn 55 because anticipation poor long-term outcome. Of 497 surviving 10% developed severe intraventricular haemorrhage (IVH), 5.7% cystic periventricular leucomalacia (cPVL), 41% septicaemia 5.8%...
In a 2‐year (1990‐92) prospective national investigation, comprising all stillborn and live‐born ELBW infants with birthweight of ≤1000 g born at 23 completed weeks gestation or more, we examined the incidence, neonatal mortality, major morbidity infant survival in relation to level care place residence. A total 633 were live‐born, i.e. 0.26% infants, 298 stillborn. The average mortality was 37% 91% weeks, 70% 24 40% 25 gestation. Of survivors, 8% had intraventricular haemorrhage grade 3,10%...
Objective. There is a need for evidence-based knowledge regarding perinatal management in extreme prematurity. The benefit of proactive attitude versus more selective one controversial. objective the present study was to analyze practices and infant outcome prematurity relation different policies North (proactive) South Sweden. Methods. A population-based, retrospective, cohort design used. Data Swedish Medical Birth Register (MBR) from 1985 1999 were analyzed according region birth...
OBJECTIVE. We investigated a national cohort of extremely immature children with respect to behavioral and emotional problems social competencies, from the perspectives parents, teachers, themselves. METHODS. examined 11-year-old who were born before 26 completed weeks gestation in Sweden between 1990 1992. All had been evaluated at corrected age 36 months. At 11 years age, 86 89 survivors studied compared an equal number control subjects, matched gender. Behavioral problems, adaptive...
<h3>Importance</h3> There are concerns that apparently healthy extremely preterm children face a risk of developing motor impairments, such as developmental coordination disorder. <h3>Objective</h3> To evaluate the prevalence disorder and associated comorbidities in national cohort born at 22 to 26 gestational weeks, compared alongside term-born peers. <h3>Design, Setting, Participants</h3> This prospective, population-based study included all who were consecutively weeks Sweden from April...
(Abstracted from JAMA 2019;321(12):1188–1199) The long-term health outcomes for preterm infants have improved over time, but born at extreme gestational ages continue to present issues of optimal antenatal and postnatal management, resource allocation costs, quality care, outcomes. To better understand variations time trends management extremely birth, study international populations is needed.
BACKGROUND. Knowledge of long-term growth extremely preterm infants in relation to gestational age is incomplete, and there are concerns regarding their poor early childhood. As part a longitudinal study national cohort born at &lt;26 weeks' gestation (extremely immature), development from birth the 11 years was examined, correlates attainment were analyzed. METHODS. Two hundred forty-seven immature children alive April 1990 through March 1992 whole Sweden, 89 (36%) survived. Growth...
In a prospective study, feeding routines of maternity unit and the subsequent patterns 521 newborns were analysed. During stay in unit, 69% exclusively breast fed 1% received only donor's milk from bank and/or formula. Nine percent their mothers' by bottle at least once 21% one or more supplementary feedings with bank. One-quarter children feeds on third day life, indications for this being birth weight less than 3.0 kg, maternal diabetes gestational diabetes, "insufficient amounts"...
To explore associations between energy and macronutrient intakes early growth in extremely low gestational age (ELGA) infants.Retrospective population-based study of all ELGA infants (<27 weeks) born Sweden during 2004-2007. Detailed data on nutrition anthropometric measurements from birth to 70 days postnatal were retrieved hospital records.Study (n = 531) had a mean ± SD 25.3 1.1 weeks weight 765 170 g. Between 0 days, average daily protein 120 11 kcal/kg 3.2 0.4 g/kg, respectively. During...
To examine the association between intensity of perinatal care and outcome at 2.5 years' corrected age (CA) in extremely preterm (EPT) infants (<27 weeks) born Sweden during 2004-2007.A national prospective study 844 fetuses who were alive mother's admission for delivery: 707 live born, 137 stillborn. Infants assigned a activity score on basis (rates key interventions) infant's region birth. Scores calculated separately each gestational week (gestational [GA]-specific scores) aggregated...
The risk of cerebral palsy (CP) is high in preterm infants and often accompanied by additional neurodevelopmental comorbidities. present study describes lifetime prevalence CP a population-based prospective cohort children born extremely preterm, including the type severity other comorbidities (ie, developmental delay and/or cognitive impairment, neurobehavioral morbidity, epilepsy, vision hearing impairments), overall disability. In this study, we also evaluate whether age at assessment,...
Uncertainty continues regarding the extent to which neonatal morbidities predict poor long-term outcome and functional abilities in extremely preterm infants.The goal of this study was determine impact bronchopulmonary dysplasia (BPD), ultrasonographic signs brain injury, severe retinopathy prematurity (ROP) on 11-year outcomes infants born at <26 weeks' gestation.A total 247 were alive before 26 completed weeks gestation from 1990 through 1992 all Sweden, 98 (40%) survived a postmenstrual...
Abstract Aim The aim of this study was to investigate differences in mortality up 1 year age extremely preterm infants (before 27 weeks) born seven Swedish healthcare regions. Methods National prospective observational consecutively born, Sweden 2004–2007. Mortality compared between Crude and adjusted odds ratios 95% CI were calculated. Results Among 844 foetuses alive at mother's admission for delivery, regional identified perinatal the total group (22–26 stillbirth 365‐day rates subgroup...
<h3>Importance</h3> This follow-up study of extremely preterm (EPT) children (<27 weeks’ gestational age [GA] at birth) revealed major eye and visual problems in 37.9% (147 388) all EPT infants 55.4% (67 121) the most immature subgroups 6.5 years age. These were strongly associated with treatment-requiring retinopathy prematurity (ROP). <h3>Objectives</h3> To investigate ophthalmologic outcome a national cohort to evaluate impact ROP. <h3>Design, Setting, Participants</h3> All surviving...
A population-based observational study investigated the contribution of obstetric factors to survival and postnatal development extremely preterm infants.Mortality up 1 year neurodevelopment at 2.5 years (Bayley-III test, cerebral palsy, vision, hearing) were evaluated in infants born before 27 weeks gestation Sweden 2004-2007 (n = 1011), using logistic regression analyses risk factors.Of 844 fetuses alive admission, 8.4% died utero labor, 7.8% intrapartum. Of 707 live-born infants, 15%...
BACKGROUND. Children born extremely immature (gestational age &lt;26 weeks' gestation) increasingly reach school age. Information on their overall functioning and special health care needs is necessary to plan for medical educational services. This study was undertaken examine neurosensory, medical, developmental conditions together with functional limitations of children compared control subjects at term. METHODS. We studied 11-year-old before 26 completed weeks gestation in all Sweden...
A survey to assess the vitamin D nutritional state in 119 pregnant women at term and their newborns was undertaken Riyadh, Saudi Arabia. Concentrations of 25-hydroxy (25-(OH)D) were below 4 ng/ml 30 maternal sera, 11 which they undetectable. The median concentration 25-(OH)D 5.7 ng/ml, is comparable that found Asian vegetarian London. Fifty cord samples had undetectable 25-(OH)D, a total 81 concentrations less than ng/ml. Despite low bloods calcium higher those blood, while serum albumin...
Fellman, V.; Hellström-Westas, L.; Norman, M.; Westgren, Källén, K.; Lagercrantz, H.; Marsál, Serenius, F.; Wennergren, M. EXPRESS GroupAuthor Information
The study aim was to explore the relationship between a developmental assessment at preschool age and an intelligence quotient (IQ) school age. One hundred sixty-two children were assessed 2.5 years with Bayley Scales of Infant Toddler Development—Third Edition (Bayley-III) then 6.5 Wechsler Intelligence Scale for Children—Fourth (WISC-IV). Bayley-III Cognitive Index score entity that showed highest correlation WISC-IV Full-Scale IQ (FSIQ; r = .41). There significant difference individual...
Abstract Aim We evaluated the increased centralisation of extremely preterm (EPT) births in Sweden relation to changes mortality and morbidity. Methods Population‐based data covering Swedish live from 22 + 0 26 6 weeks gestation during 2004–2007 2014–2016 were analysed for associations between time‐period, birth within (inborn) or outside (outborn) regional centres, outcomes. Results Among 1626 liveborn infants, 703 born 923 2014–2016. Birth (vs. within) centres was associated with a higher...
Abstract Objective Extremes of prepregnancy maternal BMI increase neonatal mortality and morbidity at term. They also the risk extremely preterm (EP, i.e., <27 weeks' gestational age) births. However, association between outcomes for EP babies is poorly understood. Methods We used a cross‐country design, bringing together following three population‐based, prospective, national birth cohorts: EXPRESS (Sweden, 2004–2007); EPICure 2 (UK, 2006); EPIPAGE (France, 2011). included all singleton...