Aditya S. Shirali

ORCID: 0000-0002-1044-8680
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About
Contact & Profiles
Research Areas
  • Angiogenesis and VEGF in Cancer
  • Aortic aneurysm repair treatments
  • Organ Transplantation Techniques and Outcomes
  • Liver Disease and Transplantation
  • Transplantation: Methods and Outcomes
  • Lung Cancer Treatments and Mutations
  • Adrenal Hormones and Disorders
  • Coronary Interventions and Diagnostics
  • Thyroid Cancer Diagnosis and Treatment
  • Hippo pathway signaling and YAP/TAZ
  • Genetic factors in colorectal cancer
  • Sepsis Diagnosis and Treatment
  • Medical Imaging and Pathology Studies
  • Vascular Anomalies and Treatments
  • Thyroid Disorders and Treatments
  • Pulmonary Hypertension Research and Treatments
  • Neuroendocrine Tumor Research Advances
  • Ferroptosis and cancer prognosis
  • Cell Adhesion Molecules Research
  • Congenital Heart Disease Studies
  • Inflammatory mediators and NSAID effects

University of Florida
2024

University of California, Los Angeles
2016-2020

Differentiated thyroid cancer in older adults has been linked to alterations the mutational landscape and tumor immune cell infiltration that create a tumor-permissive microenvironment. We sought determine impact of age on genomic composition papillary (PTC). Genomic alterations, clinical data were obtained using The Cancer Genome Atlas (TCGA) computational immunogenomic analyses. Disease severity was recoded into 3 groups: Group A (T1-2N0M0), B (T1-3N1a-1bM0), C (T4NxMx or TxNxM1)....

10.1530/erc-23-0341 article EN Endocrine Related Cancer 2024-09-01

Abstract Morbidity in patients with single-ventricle Fontan circulation is common and includes arrhythmias, edema, pulmonary arteriovenous malformations (PAVM) among others. We sought to identify biomarkers that may predict such complications. Twenty-five physiology 12 control atrial septal defects (ASD) underwent cardiac catheterization were included. Plasma was collected from the hepatic vein superior vena cava protein profiling for a panel of 20 analytes involved angiogenesis endothelial...

10.1038/s41598-019-54776-w article EN cc-by Scientific Reports 2019-12-04

The molecular mechanisms underlying vascular regeneration and repair are largely unknown. To gain insight into this process, we developed a method of intima denudation, characterized the progression endothelial healing, performed transcriptome analysis over time. Next-generation RNA sequencing (RNAseq) provided quantitative unbiased gene expression profile during in vivo following denudation injury. Our data indicate that shortly after injury, cells immediately adjacent to wound mount robust...

10.1038/s41598-018-23653-3 article EN cc-by Scientific Reports 2018-03-29

Percutaneous vascular interventions uniformly result in arterial denudation injuries that subsequently lead to thrombosis and restenosis. These complications can be attributed impairments re-endothelialization within the wound margins. Yet, cellular molecular mechanisms of remain defined. While several animal models study after are available, few performed mouse because surgical limitations. This undermines opportunity exploit transgenic lines investigate contribution specific genes process...

10.3791/54755 article EN Journal of Visualized Experiments 2016-11-24

Serum levels of procalcitonin (PCT), a protein produced by the thyroid C cells under physiologic conditions, are high during sepsis.To assess test performance serum PCT in predicting bacterial sepsis and septic shock patients with hypothyroidism compared those who have euthyroidism.This retrospective study evaluated no history dysfunction (euthyroid), primary [medical (MH)], postsurgical from total thyroidectomy (TT) identified prospectively maintained database had testing 2005 to 2018....

10.1210/jc.2019-01082 article EN The Journal of Clinical Endocrinology & Metabolism 2019-07-30

Trapped lung, characterized by atelectatic lung unable to reexpand and fill the thoracic cavity due a restricting fibrous visceral pleural peel, is occasionally seen in patients with end-stage liver disease complicated hepatic hydrothorax. Limited data suggest that trapped prior orthotopic transplantation may be associated poor outcomes.What clinical significance of receiving transplantation?We performed retrospective analysis who underwent over an 8-year period. Baseline characteristics...

10.1177/1526924820978604 article EN Progress in Transplantation 2020-12-07

Percutaneous vascular interventions uniformly result in arterial denudation injuries that subsequently lead to thrombosis and restenosis. These complications can be attributed impairments re-endothelialization within the wound margins. Yet, cellular molecular mechanisms of remain defined. While several animal models study after are available, few performed mouse because surgical limitations. This undermines opportunity exploit transgenic lines investigate contribution specific genes process...

10.3791/54755-v article EN Journal of Visualized Experiments 2016-11-24
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