A5085327891- Natural product bioactivities and synthesis
- Alkaloids: synthesis and pharmacology
- Neurological Disease Mechanisms and Treatments
- Phytochemistry and Biological Activities
- Chemical synthesis and alkaloids
- Natural Compounds in Disease Treatment
- Fungal Biology and Applications
- Biochemical and Molecular Research
- Autophagy in Disease and Therapy
- Soft Robotics and Applications
- Bone health and osteoporosis research
- Bioactive Compounds and Antitumor Agents
- HER2/EGFR in Cancer Research
- Chromatography in Natural Products
- Microbial Natural Products and Biosynthesis
- Peroxisome Proliferator-Activated Receptors
- Robotic Locomotion and Control
- Traditional and Medicinal Uses of Annonaceae
- Bioactive natural compounds
- Bone Metabolism and Diseases
- Seaweed-derived Bioactive Compounds
- Endoplasmic Reticulum Stress and Disease
- Plant biochemistry and biosynthesis
- Bone health and treatments
- Advanced Technologies in Various Fields
South China University of Technology
2024
Guangzhou Automobile Group (China)
2024
Chongqing University
2023
Jiangxi University of Traditional Chinese Medicine
2011-2021
University of Illinois Chicago
2014-2017
Third Affiliated Hospital of Southern Medical University
2015
Southern Medical University
2014
China Pharmaceutical University
2011
p62 is a well-characterized autophagy receptor that recognizes and sequesters specific cargoes into autophagosomes for degradation. promotes the assembly removal of ubiquitinated proteins by forming p62-liquid droplets. However, it remains unclear how efficiently sequester Herein, we report undergoes reversible S-acylation in multiple human-, rat-, mouse-derived cell lines, catalyzed zinc-finger Asp-His-His-Cys S-acyltransferase 19 (ZDHHC19) deacylated acyl protein thioesterase 1 (APT1)....
Cyclocarya paliurus (Batal) Iljinskaja (Juglandaceae) is an edible and medicinal plant; the leaves are used in Chinese folkloric medicine to treat dyslipidaemia diabetes.This study evaluates antihyperlipidaemic potential of triterpenic acid-enriched fraction (TAE) from C. underlying mechanism.The hyperlipidaemic rats were induced by high fat diet for 6 weeks. After oral administration TAE (200 400 mg/kg), neutral (150 300 mg/kg) statin (4 4 weeks, lipid profile apolipoprotein (apoB48) level...
It has been forecasted that the rabbiteye blueberry could inhibit osteoporosis. However, inhibition and prevention of osteoporosis via are still elusive. This study was aim to evaluate anti-osteoporosis effects in ovariectomized rats.Thirty rats were randomly divided into three groups ten each as follows: sham-operated group (SG), model control (OMG), treatment (OBG). The blood mineral levels, alkaline phosphatase (ALP) activity, osteoprotegerin (OPG) level determined. expression analyses...
Cytisine N-methylene-(5,7-dihydroxy-4'-methoxy)-isoflavone (CNF2) is a new compound isolated from the Chinese herbal medicine Sophora alopecuroides. Preliminary pharmacodynamic studies demonstrated its activity in inhibiting breast cancer cell metastasis. This study examined pharmacokinetics, absolute bioavailability, and tissue distribution of CNF2 rats, combined computer-aided technology to predict druggability CNF2. The binding site target human epidermal growth factor receptor-2 (HER2)...
Two new phenolic glucosides, including a O-glycoside (1) and C-glycoside (2), were isolated from marine-derived fungus Aspergillus sp. The structures of compounds elucidated through interpretations spectroscopic evidence high-resolution electrospray ionization mass spectrometry. hexose unit 1 was identified as β-D-glucose by comparison with an authentic sample via HPLC after acid hydrolysis derivatization. All evaluated for their ability to inhibit LPS-induced NO production in RAW264.7...
Topoisomerase I (Topo I) is a key target of many antitumor drugs in vivo. Alkaloids Sophora alopecuroides L. can reportedly inhibit Topo activity, but the pharmacodynamic material basis has not yet been determined.This study aimed to rapidly identify active components which S. L.Affinity ultrafiltration coupled with ultra-performance liquid chromatography-quadrupole time flight-mass spectrometry (UF-UPLC-QTOF-MS) screening system based on protein was established screen and isolate total...
Introduction Emergency medical service (EMS) serves as a pivotal role in linking injured road users to hospitals via offering first aid measures and transportation. This paper aims investigate the effect of emergency response time on fatality risk freeway crashes. Methods Crash injury severity data from Kaiyang Freeway, China 2014 2015 are employed for empirical investigation. A Bayesian random parameters spatial logistic model is developed analyzing crash severity. Results inference...
Ten Amaryllidaceae alkaloids were isolated from the bulbs of Lycoris radiata. Their structures identified as oxovittatine (1), apohaemanthamine (2), 9-O-demethylhomolycorine N-oxide (3), incartine (4), ismine (5), 6-O-methylpretazettine (6), tazettine (7), ungeremine (8), homolycorine (9), and O-methyllycorenine (10) by spectroscopic data analyses. Compound 1 was a new natural product. Compounds 2 3 reported form genus for first time compounds 4-6 title plant time.
Four new iboga-type alkaloids, ervaoffines A–D (1–4), were isolated from the twigs and leaves of Ervatamia officinalis. The chemical structures absolute configuration elucidated by interpretation spectroscopic data, as well X-ray diffraction circular dichroism analyses. Compounds 1 2 are first members pseudoindoxyl alkaloids bearing a C-2 spiro-carbon with opposite to that known such iboluteine. relationship between Cotton effect for oxindole was established.
Objective To investigate the value of ambulance mobile information platform in treatment acute cerebrovascular disease. Methods We established hospital emergency central station and vehicle platform. The pre-hospital was integrated by wireless transmission. study involved 45 patients with cerebral vascular diseases treated form October 2010 to June 2011 39 common from August 2009 2010. delay time survival rate were compared between groups. Results In comparison before use...