A5076117851- Asymmetric Hydrogenation and Catalysis
- Chemical Synthesis and Analysis
- Chemical Synthesis and Reactions
- Catalytic Cross-Coupling Reactions
- Sulfur-Based Synthesis Techniques
- Fluorine in Organic Chemistry
- Catalytic C–H Functionalization Methods
- Asymmetric Synthesis and Catalysis
- Carbon dioxide utilization in catalysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Catalytic Reactions
- Nanomaterials for catalytic reactions
- Advanced Synthetic Organic Chemistry
- Cyclopropane Reaction Mechanisms
- Organoboron and organosilicon chemistry
- Synthetic Organic Chemistry Methods
- Synthesis and Characterization of Pyrroles
- Luminescence Properties of Advanced Materials
- Fungal Biology and Applications
- Radical Photochemical Reactions
- Synthesis and Reactions of Organic Compounds
- Microbial Natural Products and Biosynthesis
- Crystal Structures and Properties
- Seaweed-derived Bioactive Compounds
Gannan Medical University
2019-2024
Shangrao Normal University
2019
Sun Yat-sen University
2011-2013
Chinese Academy of Sciences
2008-2009
Shanghai Institute of Organic Chemistry
2008-2009
South China University of Technology
2008
Acetonitrile is commonly used as an organic solvent and can also be important intermediate in synthesis. Its widespread use has led to the development of new methods for synthesis a variety compounds. In past decades, conversion reactions acetonitrile building block have become one most-attractive fields Especially field electrochemical conversions involving acetonitrile, due its good conductivity environmentally friendly features, it powerful compelling tool afford nitrogen-containing...
This paper develops a methodology for cyclometalated iridium complex-catalyzed N-alkylation of amines with alcohols via borrowing hydrogen in the aqueous phase. The catalyst-mediated displays high activity (S/C up to 10,000 and yield 96%) ratio amine/imine (up >99:1) broad range substrates 46 examples) using water as green eco-friendly solvent. Most importantly, this transformation is simple, efficient, can be performed at gram scale, showcasing its potential industrially synthesizing...
The cleavage and transformation of alkenyl C(sp2)-N bonds is a significant synthetic challenge. Herein we described an unprecedented nickel-catalyzed reductive borylation enaminones to synthesize β-ketone boronic esters. Notably, B2pin2 played the dual role in this process, water served as hydrogen source, which was transferred target products. air-stable nickel catalyst applied bonds, concomitant with process ester intermediates, on basis mechanism study.
The pH-dependent selective Ir-catalyzed hydrogenation of α,β-unsaturated aldehydes was realized in water. Using HCOOH as the hydride donor at low pH, unsaturated alcohol products were obtained exclusively, while saturated formed preferentially by employing HCOONa high pH. A wide range functional groups including electron-rich well electron-poor substituents on aryl group can be tolerated, affording corresponding excellent yields with TOF values. High selectivity and also observed for...
An efficient chemoselective iridium-catalyzed method for the hydroxylation and alkoxylation of organosilanes to generate hydrogen gas silanols or silyl ethers was developed. A variety sterically hindered silanes with alkyl, aryl, ether groups were tolerated. Furthermore, this atom-economical catalytic protocol can be used synthesis silanediols silanetriols. one-pot silane oxidation reduction aldehydes/ketones also realized.
Amination of allylic alcohols is an effective approach in the facile synthesis N-allylic alkylation or N-alkylation amines. Recently, a series catalysts were devised to push forward this transformation. However, current synthetic methods are typically limited achieve either products via certain catalyst. In article, pH-mediated selective amines with iridium catalyst water as environmental benign solvent revealed, enabling miscellaneous and outstanding yields. Furthermore, gram-scale...
Abstract An efficient iridium-catalyzed acceptorless dehydrogenative coupling (ADC) reaction for the preparation of various quinazolines from 2-aminoarylmethanols and amides or nitriles had been developed. A wide range substituted 2-aminobenzyl alcohols (hetero)aryl alkyl benzamides were well compatible to afford in excellent yields. Merits this new strategy are high atom-economy, mild conditions, simple operation, methodology is suitable a variety substrates.
A practical and facile difluorocarbene-triggered cycloaddition reaction of enaminones was developed, which delivered 2,2-difluoro-2,3-dihydrofurans without any extra additives.
Sulfonamide moieties widely exist in natural products, biologically active substance, and pharmaceuticals. Here, an efficient water-soluble amide iridium complexes-catalyzed transfer hydrogenation reduction of N-sulfonylimine is developed, which can be carried out under environmentally friendly conditions, affording a series sulfonamide compounds excellent yields (96–98%). In comparison with organic solvents, water shown to critical for high catalytic the catalyst loading as low 0.001 mol %....
A substrate-controlled stereoselective semi-reduction of alkynes with MeOH as the hydrogen source has been developed, and readily available Cu(OAc)2 (copper acetate) is utilized an optimal catalyst. The detailed investigation mechanism revealed distinct catalytic processes for (Z)- (E)-alkenes, respectively. As a result, diversity (including terminal, internal etc.) were compatible under mild reaction conditions. Furthermore, high proportion deuterium in Z-alkenes (up to 96%) was obtained...
A base-promoted amidation of 1-aryl-2,2,2-trifluoroethanones with amines via Haller–Bauer reaction has been developed. This directly transforms aryl trifluoroethanone into amides without the use stoichiometric chemical oxidants or transition-metal catalysts.
Abstract Ketones are of great importance in synthesis, biology, and pharmaceuticals. This paper reports an iridium complexes‐catalyzed cross‐coupling alcohols via hydrogen borrowing, affording a series α ‐alkylated ketones high yield (86 %–95 %) chemoselectivities (>99 : 1). methodology has the advantages low catalyst loading (0.1 mol%) environmentally benign water as solvent. Studies have shown amount base impact on chemoselectivities. Meanwhile, deuteration experiments show plays...
A novel protocol facilitated by Na2SO3 that enhances the efficiency of palladium-catalyzed Heck coupling and homo-coupling reactions arylhydrazines. This innovative method enables effective construction a diverse array cinnamate derivatives biphenyl compounds. Notably, these transformative proceed smoothly at room temperature, leveraging activation C-N bonds. technique not only streamlines synthesis process but also expands our understanding expertise in realm reactions.
Organosulfur compounds with unsymmetrical S–S bonds are usually called disulfides and widely used in the biological, medicinal, chemical fields. Their versatility has guided development of various new methods for synthesis disulfides. In recent years, by cross-dehydrogenation thiols attracted much attention due to its high atomic economy. Herein, this review summarizes progress toward under oxidation, electrooxidation, or photocatalysis thiols.
A practical and efficient method for the synthesis of alcohols in one pot from readily available alkynes via a tandem process by formic acid promoted hydration metal-ligand bifunctional iridium-catalyzed transfer hydrogenation under mild conditions has been described. This transformation is simple, efficient, can be performed with variety good yields excellent stereoselectivities. Experimental results showed high catalytic activity, turnover frequency (TOF) up to 25000. Importantly, this...