A5048257624- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Click Chemistry and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Membrane Separation Technologies
- Membrane-based Ion Separation Techniques
- Analytical Chemistry and Sensors
- Surface Modification and Superhydrophobicity
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Luminescence and Fluorescent Materials
- Fuel Cells and Related Materials
- Photodynamic Therapy Research Studies
- Advanced Biosensing Techniques and Applications
- Nanomaterials for catalytic reactions
- Synthesis and Characterization of Pyrroles
- Synthesis and Reactivity of Heterocycles
- Advanced Sensor and Energy Harvesting Materials
- Cyclopropane Reaction Mechanisms
- Graphene and Nanomaterials Applications
- Multicomponent Synthesis of Heterocycles
- Graphene research and applications
- Metal complexes synthesis and properties
- Fluorine in Organic Chemistry
- Monoclonal and Polyclonal Antibodies Research
Guangdong Medical College
2024
Guiyang Medical University
2024
Guizhou Provincial People's Hospital
2024
Guizhou University
2024
Gannan Medical University
2019-2024
Jilin University
2024
Southern University of Science and Technology
2022
Chengdu University of Traditional Chinese Medicine
2022
Ganzhou People's Hospital
2021
Jiangxi Academy of Sciences
2019-2021
A lanthanide-based three-dimensional metal–organic framework with excellent water, acid/base, and solvent stability, namely {[(CH3)2NH2]0.7[Eu2(BTDBA)1.5(lac)0.7(H2O)2]·2H2O·2DMF·2CH3CN}n (JXUST-29, H4BTDBA = 4′,4‴-(benzo[c][1,2,5]thiadiazole-4,7-diyl)bis([1,1′-biphenyl]-3,5-dicarboxylic acid), Hlac lactic has been synthesized characterized. Since the N atoms of thiadiazole group will not coordinate lanthanide ions, JXUST-29 a free basic N-site accessible to small H+ which allows it be used...
Extreme hypoxia together with the expression of hypoxia-inducible factor-1α (HIF-1α) represents a significant barrier against effective photodynamic therapy (PDT) tumor. To mitigate these issues, we created core–shell nanosystem that can simultaneously alleviate tumor and suppress HIF-1α to combat resistance PDT. Specifically, carrier-free, dual-drug nanocore was formed by self-assembly hydrophobic photosensitizer (chlorin e6, Ce6) rapamycin (RAP), then surface coated layer metal–organic...
The combination of chemotherapy and photodynamic therapy provides a promising approach for enhanced tumor eradication by overcoming the limitations each individual therapeutic modality. However, is pathologically featured with extreme hypoxia together adaptable overexpression anti-oxidants, such as glutathione (GSH), which greatly restricts efficiency. Here, combinatorial strategy was designed to simultaneously relieve self-oxygenation reduce intracellular GSH level sensitize...
Abstract Comprehensive understanding of signaling pathways regulating cancer progression has led to tremendous advances molecularly targeted therapies. The epidermal growth factor receptor (EGFR) pathway is an attractive target for therapy, and targeting multiple key elements in the may further facilitate therapeutic efficacy. Here, EGFR‐targeted nanoprodrug demonstrated vivo imaging tumor inhibition, which assembled by a disulfide‐bridged quercetin (QSSQ) EGFR inhibitor erlotinib. QSSQ...
Photothermal therapy (PTT) is a promising tumor treatment modality, but its efficacy strictly hindered by abnormally upregulated heat shock proteins (HSPs) in cells under stress. Herein, we developed flower-like MnO2-coated polydopamine (PDA@MnO2) core-shell nanoplatform with the surface adsorption of HSP70-silencing DNAzyme (DZ) for enhanced PPT. The PDA core acted as robust photothermal agent, and also reductant to allow growth MnO2via an situ reduction KMnO4. MnO2 shell enabled rapid...
Herein, a B2pin2-mediated radical cascade cyclization/aromatization reaction of enaminone with pyridine is described. This strategy provides practical way for the construction valuable functionalized indolizines under metal-, external oxidant-, and base-free conditions, which could be compatible various kinds functional groups, such as halogen, π-system, heterocycle, ferrocenyl, etc. A preliminary mechanism investigation indicated that pyridine-boryl formed in situ triggered to occur.
Abstract Non‐small cell lung cancer (NSCLC) is the most common type of and cause high rate mortality. The epidermal growth factor receptor (EGFR)‐targeted tyrosine kinase inhibitors are used to treat NSCLC, yet their curative effects usually compromised by drug resistance. This study demonstrates a nanodrug for treating tyrosine‐kinase‐inhibitor‐resistant NSCLC through inhibiting upstream downstream EGFR signaling pathways. main molecule synthesized linking inhibitor gefitinib near‐infrared...
A dual-functional sensor based on a two-dimensional metal–organic framework (MOF), namely, {[Cd(BBZB)(2,6-NDC)]·CH3OH}n (JXUST-6, BBZB = 4,7-bis(1H-benzimidazole-1-yl)-2,1,3-benzothiadiazole and 2,6-NDC 2,6-naphthalenedicarboxylate), has been designed synthesized under solvothermal conditions. JXUST-6 exhibits good stability in aqueous solution, boiling water, N,N-dimethylformamide (DMF) solution. Luminesecence studies of reveal the existence fluorescence red shift toward Al3+ Ga3+...
A sequential enzyme-activated and light-triggered pro-prodrug has been developed for cancer biomarker detection on-demand therapy.
Polyaniline core decorated with TiO 2 (PANI‐TiO ) nanocomposite particles was successfully synthesized in ionic liquid/water (IL/water) microemulsion the presence of anatase nanoparticles. The nanoparticles had been dispersed beforehand OP‐10 and n ‐butanol to weaken strong agglomeration . PANI‐TiO nanocomposites were characterized by fourier transform infrared spectroscopy (FTIR), ultraviolet visible (UV‐Vis), scanning electron microscopy (SEM), transmission microscope (TEM), their...
Bioorthogonal bond-cleavage reaction is a newly-emerged and efficient tool for controlled activation of probes prodrugs, which merits further exploration, especially its application in live animals. In this study, bioorthogonal system based on tetrazine-mediated inverse electron-demand Diels–Alder was fabricated to achieve fluorescence imaging prodrug simultaneously. A vinyl ether-caged CPT synthesized utilized as the anti-tumor prodrug, tetrazine derivative linked with near-infrared dye...
In this study, modification of polysulfone (PSf)/sulfonated (SPSf) blended porous ultrafiltration (UF) support membranes was proposed to improve the reverse osmosis (RO) performance aromatic polyamide thin film composite (TFC) membranes. The synergistic effects solvent, polymer concentration, and SPSf doping content in casting solution were investigated systematically on properties both supports RO SEM AFM combined characterize physical membranes, including surface pore natures (porosity,...
Bioorthogonal "bond cleavage" reactions hold great promise in a variety of biological applications such as controlled activation the drug and probe, while application these biocompatible living animals is still its infancy has yet to be further explored. Herein we demonstrate nanosized two-component bioorthogonal system for tumor inhibition through combined action chemo- photothermal therapy. The trigger was fabricated by immobilizing PEGylated tetrazine on gold nanorods, prodrug synthesized...
A practical and facile difluorocarbene-triggered cycloaddition reaction of enaminones was developed, which delivered 2,2-difluoro-2,3-dihydrofurans without any extra additives.
RNA N6-methyladenosine (m6A) readers mediate cancer progression. However, the functional role and potential mechanisms of m6A in prostate tumorigenicity remain to be elucidated. In this study, we demonstrate that YTHDF3 expression is elevated castration-resistant (CRPC) positively correlated high grade, bone metastasis poor survival. promoted CRPC cell proliferation, epithelial mesenchymal transition (EMT) tumour Mechanistically, degradation SPOP NXK3.1 but stabilized expressions TWIST1...