A5102022337- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Natural product bioactivities and synthesis
- Cancer, Hypoxia, and Metabolism
- Ginseng Biological Effects and Applications
- Plant biochemistry and biosynthesis
- RNA Research and Splicing
- Animal Disease Management and Epidemiology
- Mechanisms of cancer metastasis
- Peroxisome Proliferator-Activated Receptors
- Extracellular vesicles in disease
- Traditional Chinese Medicine Analysis
- Fibroblast Growth Factor Research
- RNA and protein synthesis mechanisms
- Cancer-related Molecular Pathways
- Histone Deacetylase Inhibitors Research
- Heme Oxygenase-1 and Carbon Monoxide
- Evaluation of Teaching Practices
- Phytochemicals and Antioxidant Activities
- Lipid metabolism and disorders
- Traditional and Medicinal Uses of Annonaceae
- Bioactive natural compounds
- Enzyme function and inhibition
- Nuclear Engineering Thermal-Hydraulics
Zhejiang University
2013-2024
China Pharmaceutical University
2018-2024
Beijing Normal University
2024
Institute of Pomology
2023
Fujian Medical University
2019-2023
Zhangzhou Municipal Hospital of Fujian Province
2019-2023
Gansu Agricultural University
2023
Jilin University
2022-2023
Nanjing University of Chinese Medicine
2019-2021
Nanjing Traditional Chinese Medicine Hospital
2021
Purpose: Laryngeal carcinomas always resist to radiotherapy.Hypoxia is an important factor in radioresistance of laryngeal carcinoma.Glucose transporter-1 (GLUT-1) considered be a possible intrinsic marker hypoxia malignant tumors.We speculated that the inhibition GLUT-1 expression might improve radiosensitivity carcinoma.Methods: We assessed effect on carcinoma and expressions by antisense oligodeoxynucleotides (AS-ODNs) vitro vivo.Results: After transfection AS-ODNs: MTS assay showed...
Cetuximab is a monoclonal antibody that acts as an anti-EGFR agent. inhibits the phosphorylation and activation of EGFR blocks downstream signal pathways EGF/EGFR, including Ras-Raf-MAPK PI3K-Akt pathways. Akt important factor in cetuximab resistance. It has been reported resveratrol connexin 43 regulate different ways based on tissue type. Since interacts with Akt, known to upregulate 43, we investigated whether can sensitize colorectal cancer cells via upregulation. Our work confirmed...
MicroRNAs (miRNAs) have emerged as key modulators in the pathophysiologic processes of cardiovascular diseases. However, its function cardiac injury induced by obstructive sleep apnea (OSA) remains unknown. The aim current study was to identify effect and potential molecular mechanism miR-146a-5p intermittent hypoxia(IH)- myocardial damage. We exposed H9c2 cells IH condition; expression levels were detected RT-qPCR. Cell viability, cell apoptosis, expressions apoptosis-associated proteins...
Summary There is evidence to show that downregulation of miR‐1 expression closely related cancer progression, including in nasopharyngeal carcinoma ( NPC ). However, the molecular mechanisms underlying remain largely unknown, especially its association with Epstein–Barr virus EBV In this study we found restoration dramatically inhibited cell invasion vitro , together tumour growth and metastasis vivo . Importantly, LMP 1, an )‐associated protein, suppressed expression. Furthermore,...
Recently, long non-coding RNAs (lncRNAs) have been elucidated to play essential roles in cancers, and the recognition of lncRNA expression patterns nasopharyngeal carcinoma (NPC) may be helpful for indicating novel mechanisms underlying NPC carcinogenesis. Herein, we conducted this study probe into function ZNF667-AS1 progression with involvement microRNA-1290 (miR-1290) actin-binding LIM protein 1 (ABLIM1).In silico analysis screened differentially expressed genes miRNAs predicted potential...
Abstract Background This study is to explore the role of curcumin and GLUT‐1 antisense oligodeoxynucleotides (AS‐ODN) on autophagy modulation‐initiated radiosensitivity. Methods BALB/c mice were employed establish xenograft model using Tu212 cell. The expression autophagy‐ apoptosis‐related proteins was determined by WB. Autophagosome observed under transmission electron microscope. Apoptosis tumor tissue detected TUNEL staining. Results Combinations AS‐ODN with 10 Gy inhibited growth...
Dietary saponins have the potential to ameliorate atherosclerosis (AS). Gypenosides of Gynostemma pentaphyllum (GPs) been used as functional foods exhibit antiatherosclerotic activity. The present study aimed explore protective effect, underlying mechanism and active substances GPs on AS in vivo vitro. Results demonstrated administration reduced serum concentrations TC LDL-C, upregulated plasma HDL-C content, inhibited secretion ICAM-1, VCAM-1, MCP-1, alleviated vascular lesions VitD3 plus...
Glucose transporter (GLUT)-mediated glucose uptake is an important process in the development of laryngeal carcinoma, one most common malignancies head and neck. GLUT-1, together with HIF-1α, also indicator hypoxia. Both proteins play a critical role glycolysis carcinoma cells under hypoxic stress. A double gene knockout model which HIF-1α GLUT-1 are no longer expressed can provide information about carcinogenesis carcinoma.In this study we used CRISPR/Cas 9 system to induce HEp-2 then...
Background Dysfunctional mitochondria are associated with neurological injury after cardiac arrest ( CA ). Although carbon monoxide CO ) has shown various potential therapeutic effects in preclinical tissue models, its mechanism of action remains unclear. We sought to investigate the a novel ‐releasing molecule on cerebral mitochondrial dysfunction and . Methods Results Male Sprague‐Dawley rats aged 20 22 months were subjected 6‐minute asphyxia before receiving treatment. Survival,...
Intermittent hypoxia (IH) is a prominent feature of obstructive sleep apnea (OSA) which increasingly recognized as key risk factor for liver injury. Circular RNAs (circRNAs) has been suggested to act regulator multiple biological processes. However, there no study evaluating circRNAs alterations and potential role in OSA-related The present aimed investigate circRNA expression profiles vitro model IH-induced injury, well functional characterization the differentially expressed (DE circRNAs)....
Recent research on the structure and mechanism of DNA polymerases has continued to generate fundamentally important features, including a noncanonical pathway involving "prebinding" metal-bound dNTP (MdNTP) in absence DNA. While this was shown be possible subset for African swine fever polymerase X (Pol X) human Pol λ, it remains unknown whether could primary polymerase. μ is unique member X-family with multiple functions unusual Mn2+ preference. Here we report that not only prebinds MdNTP...
Anoectochilus roxburghii is a well-known and valuable traditional Chinese herb due to various medicinal functional benefits. In-depth investigation necessary discover active ingredients expand its application. In this study, four new compounds (1-4) along with ten known (5-14) were isolated from the ethanol extract of A.roxburghii. Their structures elucidated by spectroscopic data interpretation. The isolates screened for their inhibitory activities on production NO in lipopolysaccharide...
Utilizing thermal updrafts shows potential for enabling long-endurance cruising of fixed-wing unmanned aerial vehicles without energy consumption. This article presents a novel online method based on sparse identification nonlinear dynamics (SINDy) approach to achievement sources in the atmosphere. Initially, algorithm is incorporated into upper-level planning system, interacting with lower-level controller. Then, experiments are conducted through software-in-the-loop simulations (SITL)...
Piper sintenense Hatusima (PsH) is a member of the genus used as food and folk medicine in China. However, detailed chemical ingredients potential pharmacological effects are still underexploited. In this study, we evaluated anti-inflammatory antigouty arthritis effect ethanolic extract P. sintenense. Active compounds were isolated from petroleum ether fraction resulting six novel amide alkaloids (1–6) 13 known analogues (7–19). All exhibited excellent activities. Bioinformatics analysis...