A5051464087- Tissue Engineering and Regenerative Medicine
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Risk Factors
- Cardiac Health and Mental Health
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Ischemia and Reperfusion
- Extracellular vesicles in disease
- Cardiovascular Function and Risk Factors
Sir Run Run Shaw Hospital
2023-2024
Zhejiang University
2023-2024
Abstract Mesenchymal stem cell‐derived extracellular vesicle (MSC‐EV) is shown to promote cardiac repair, however, it still falls short in initiating myocardia proliferation restart. In this regard, ROS‐induced DNA damage and responses are the culprit of cellcycle arrest. Here, work constructs a hybrid that composed MSC macrophage membranes encompasses MitoN, ROS scavenger, boost healing heart. The NAD(P)H mimic, could target mitochondrial eliminate resuming arrested cell cycle. (N@MEV)...
Metabolic reprogramming is critical in the onset of pressure overload-induced cardiac remodeling. Our study reveals that proline dehydrogenase (PRODH), key enzyme metabolism, reprograms cardiomyocyte metabolism to protect against We induced remodeling using transverse aortic constriction (TAC) both cardiac-specific PRODH knockout and overexpression mice. results indicate expression suppressed after TAC. Cardiac-specific mice exhibited worsened dysfunction, while with demonstrated a...
Elevated low-density lipoprotein cholesterol (LDL-C) is an established risk factor for atherosclerotic cardiovascular disease (ASCVD). However, low adherence to medication and lifestyle management has limited the benefits of lowering lipid levels. Cognitive behavioral therapy (CBT) been proposed as a promising solution.This trial aimed evaluate efficacy mobile-based CBT interventions in LDL-C levels patients with ASCVD.This multicenter, prospective, randomized controlled enrolled 300 ASCVD,...
<sec> <title>BACKGROUND</title> Elevated low-density lipoprotein cholesterol (LDL-C) is an established risk factor for atherosclerotic cardiovascular disease (ASCVD). However, low adherence to medication and lifestyle management has limited the benefits of lowering lipid levels. Cognitive behavioral therapy (CBT) been proposed as a promising solution. </sec> <title>OBJECTIVE</title> This trial aimed evaluate efficacy mobile-based CBT interventions in LDL-C levels patients with ASCVD....