A5002860390- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Cardiovascular Syncope and Autonomic Disorders
- ECG Monitoring and Analysis
- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Health Systems, Economic Evaluations, Quality of Life
- Ion channel regulation and function
- Cardiomyopathy and Myosin Studies
- Receptor Mechanisms and Signaling
- COVID-19 Clinical Research Studies
- Cardiovascular Disease and Adiposity
- Heart Rate Variability and Autonomic Control
- Mindfulness and Compassion Interventions
- Eicosanoids and Hypertension Pharmacology
- Acute Myocardial Infarction Research
- Healthcare Systems and Reforms
- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
- Cardiac Arrest and Resuscitation
University of California, Davis
2015-2024
University of California Davis Medical Center
2007-2024
Heart Rhythm Society
2023
Ospedale dei Pellegrini
2022
Stord hospital
2022
Henry Ford Hospital
2005
University of California, San Diego
2005
Olive View-UCLA Medical Center
2003
West Los Angeles College
2002
Cardiac physiologic pacing (CPP), encompassing cardiac resynchronization therapy (CRT) and conduction system (CSP), has emerged as a strategy that may mitigate or prevent the development of heart failure (HF) in patients with ventricular dyssynchrony pacing-induced cardiomyopathy. This clinical practice guideline is intended to provide guidance on indications for CRT HF CPP pacemaker HF, patient selection, pre-procedure evaluation preparation, implant procedure management, follow-up...
Torsade de Pointes (TdP), a rare but lethal ventricular arrhythmia, is toxic side effect of many drugs. To assess TdP risk, safety regulatory guidelines require quantification hERG channel block in vitro and QT interval prolongation vivo for all new therapeutic compounds. Unfortunately, these have proven to be poor predictors torsadogenic are likely prevented safe compounds from reaching clinical phases. Although this has stimulated numerous efforts define paradigms cardiac safety, none the...
Background: Ablation for atrial fibrillation (AF) is superior to medical therapy rhythm control. We compared stroke and mortality among patients undergoing ablation AF matched controls in a large multiethnic population. Methods: Using discharge surgical records from California nonfederal hospitals, we identified who had principal diagnosis of with at least 1 prior hospitalization AF. excluded cases valve disease, open maze, other arrhythmias, or implantable devices. Matched were selected...
Background: Data on atrial fibrillation (AF) ablation and outcomes are limited in patients with congenital heart disease (CHD). We aimed to investigate the characteristics of CHD presenting for AF their outcomes. Methods: A multicenter, retrospective analysis was performed undergoing between 2004 2020 at 13 participating centers. The severity classified using 2014 Pediatric Congenital Electrophysiology Society/Heart Rhythm Society guidelines. Clinical data were collected. One-year complete...
Abstract Aims To determine outcomes in atrial fibrillation patients undergoing percutaneous left appendage occlusion (LAAO) based on the underlying stroke risk (defined by CHA2DS2-VASc score). Methods and results Data were extracted from National Inpatient Sample for calendar years 2016–20. Left implantations identified basis of International Classification Diseases, 10th Revision, Clinical Modification code 02L73DK. The study sample was stratified score into three groups (scores 3, 4, ≥5)....
Sudden cardiac death (SCD) is a major cause of mortality secondary to coronary artery disease (CAD) in the industrialized societies. Although South Asians have high prevalence CAD, frequency and underlying pathology SCD among this population are unknown.Medical records consecutive patients presenting with unexplained sudden (USD) tertiary care center were reviewed. Patients trauma, violent deaths, positive toxicology non-cardiac excluded determine (SCD). Cardiac pathological findings...
To determine outcomes in atrial fibrillation (AF) patients undergoing percutaneous left appendage occlusion (LAAO) with concomitant heart failure preserved ejection fraction (HFpEF) and reduced (HFrEF).Data were extracted from National Inpatient Sample for calendar years 2015-2019. LAAO device implantations identified on the basis of ICD-10-CM code 02L73DK. The assessed our study included complications, in-patient mortality, resource utilization. A total 62 980 studied. HFpEF (14.4%, n =...
Few innovations have the potential to reconfigure clinical care as thoroughly digital medicine. One likely future of continuous physiological monitoring by novel devices—analyzed artificial intelligence (AI)-guided algorithms and stored in secure repositories—to develop personal biometrics guide care, improve risk stratifiers, predict events is both exciting daunting. It unclear how practitioners patients will transition that possible future, yet all stakeholders can at present time directly...
Heat-shock proteins (HSPs) are members of a highly conserved group that induced in response to stress and injury. These have protective properties, can protect the heart from HSP60 is found mitochondria cytosol, has essential intracellular functions including folding key after their import into mitochondria. In binds proapoptotic proteins, sequestering them. HSPs and, thus, similar bacterial proteins. Many individuals antibodies HSP60, possibly prior infections. be plasma membrane serum...
There is a dearth of information about cardiovascular problems in fragile X premutation carriers who have 55-200 CGG repeats mental retardation 1 (FMR1) gene. The FMR1 expansion the range leads to toxic RNA gain-of-function resulting cellular dysregulation. mechanism toxicity underlies all disorders including X-associated tremor/ataxia syndrome, primary ovarian insufficiency, and neuropsychiatric disorder. Cardiovascular particularly autonomic dysfunction, hypertension, cardiac arrhythmias...
Background: The impact of altered ventricular activation, including biventricular (BV) pacing, on T‐wave alternans (TWA) and arrhythmic substrates is unclear. We studied how differing activation sequence alters TWA; the interval from peak‐to‐end (TpTe) amplitude during right (RV), left (LV), pacing; atrial (RA) pacing in patients with preexisting conduction delay. Methods Results: measured TWA RA, RV, LV, BV 33 receiving cardiac‐resynchronization‐therapy‐defibrillators. magnitude (V alt )...
We report a case of sarcoidosis presenting initially as atrial fibrillation(AF). His response to anti-arrhythmic treatment strategy was suboptimal. On initiation immunosuppressive therapy, AF better controlled. This interesting highlights likely link between inflammation and pathogenesis fibrillation.
Age-stratified analyses of atrial fibrillation (AF) patients undergoing percutaneous left appendage occlusion (LAAO) are limited. The purpose current study was to compare in-hospital outcomes in elderly AF (age > 80 years) a relatively younger cohort £ after LAAO.Data were extracted from National Inpatient Sample for calendar years 2015-2018. LAAO device implantations identified on the basis International Classification Diseases, 9th and 10th Revision, Clinical Modification codes 37.90...