A5086240463- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac Valve Diseases and Treatments
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Cardiovascular Syncope and Autonomic Disorders
- ECG Monitoring and Analysis
- Neurological disorders and treatments
- Infective Endocarditis Diagnosis and Management
- Heart Rate Variability and Autonomic Control
- Sports injuries and prevention
- Cardiac Fibrosis and Remodeling
- Mechanical Circulatory Support Devices
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Issues in Pregnancy
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cerebrospinal fluid and hydrocephalus
- Tissue Engineering and Regenerative Medicine
- Cardiac and Coronary Surgery Techniques
- Vascular anomalies and interventions
- Myasthenia Gravis and Thymoma
University Hospitals of Cleveland
2007-2023
University School
1996-2023
Case Western Reserve University
2007-2023
Denver School of Nursing
2022
Triangle
2022
Committee on Publication Ethics
2022
John Wiley & Sons (United States)
2022
MetroHealth Medical Center
1997-2020
University Hospitals Cleveland Medical Center
2008-2016
University of California, San Francisco
2000-2014
AMI : acute myocardial infarction ARVC : arrhythmogenic right ventricular cardiomyopathy BrS : Brugada syndrome CACS : coronary artery calcium score CAD : disease ChD : Chagas heart disease CMR : cardiac magnetic resonance CPVT : catecholaminergic polymorphic tachycardia CTCA : computed tomography angiography CV : cardiovascular DCM : dilated cardiomyopathy EAPCR : European Association for Cardiovascular Prevention and Rehabilitation HCM : hypertrophic cardiomyopathy LGE : late gadolinium...
Genetic testing has advanced significantly since the publication of 2011 HRS/EHRA Expert Consensus Statement on State Testing for Channelopathies and Cardiomyopathies.1Ackerman M.J. Priori S.G. Willems S. Berul C. Brugada R. Calkins H. et al.European Heart Rhythm Association (EHRA)HRS/EHRA expert consensus statement state genetic channelopathies cardiomyopathies: this document was developed as a partnership between Society (HRS) European (EHRA).Europace. 2011; 13: 1077-1109Crossref PubMed...
Genetic testing has advanced significantly since the publication of 2011 HRS/EHRA Expert Consensus Statement on State Testing for Channelopathies and Cardiomyopathies.1 In addition to single-gene testing, there is now ability perform whole-exome sequencing (WES) whole-genome (WGS). There growing appreciation oligogenic disorders,2, 3 role modifier genes,2 use genetic risk stratification, even in common cardiac diseases such as coronary artery disease or atrial fibrillation (AFib), including...
Cardiac physiologic pacing (CPP), encompassing cardiac resynchronization therapy (CRT) and conduction system (CSP), has emerged as a strategy that may mitigate or prevent the development of heart failure (HF) in patients with ventricular dyssynchrony pacing-induced cardiomyopathy. This clinical practice guideline is intended to provide guidance on indications for CRT HF CPP pacemaker HF, patient selection, pre-procedure evaluation preparation, implant procedure management, follow-up...
Background —In survivors of congenital heart surgery, intra-atrial reentrant tachycardia (IART) often develops. Previous reports have emphasized the atriotomy scar as central barrier around which a circuit may rotate but not systematically evaluated atrial flutter isthmus in such patients. We sought to determine role supporting IART group postoperative patients with disease. Methods and Results —Nineteen underwent electrophysiological studies entrainment mapping for determining postpacing...
Voltage‐Guided Atrial Fibrillation Substrate Ablation Introduction Left atrium (LA) low voltage area (LVA) on 3‐D electroanatomic bipolar mapping (EAVM), as a surrogate for scar, is associated with poor AF ablation outcome. We evaluated the long‐term outcome of an LVA‐guided atrial fibrillation (AF) substrate modification strategy adjunct to pulmonary vein isolation (PVI). Methods and Results Two hundred one consecutive patients (82% persistent/Non‐PAF, age 65 years), who underwent EAVM...
AV Parasympathetic Innervation. Introduction: We hypothesized that in humans there is an epicardial fat pad from which parasympathetic ganglia supply the node. also nerves innervating node innervate right atrium, and greatest density of innervation near nodal pad. Methods Results: An junction left atrium inferior pulmonary vein was identified during cardiac surgery seven patients. A ring electrode used to stimulate this intraoperatively sinus rhythm produce transient complete heart block....
Left atrial (LA) electroanatomical voltage mapping (EAVM) correlates with scar on LGE-MRI and has been used to guide ablation of low area (LVA) in sinus rhythm (SR). We compared EAVM SR AF a cohort patients, between patients without or structural heart disease (control).Twenty-seven 9 paroxysmal (PAF), underwent point-by-point during using same Carto3 geometry. Only adjacent SR-AF points (≤ 5 mm apart) were compared. In addition, 6 control evaluated. There was linear bipolar correlation (r =...
Twelve lead ECGs have limited value in precisely identifying atrial and ventricular activation during arrhythmias, including accessory atrioventricular conduction activation. The aim of this study was to report a single center's clinical experience validating novel, noninvasive, whole heart, beat-by-beat, 3-dimensional mapping technology with invasive electrophysiological studies, ablation, where applicable.Using an electrocardiographic (ECM) system 27 patients, epicardial maps were...
Abstract Background Voltage‐guided substrate ablation following pulmonary vein isolation (PVI) improves atrial fibrillation (AF) outcomes. However, by setting an upper voltage cutoff of 0.5 mV during sinus rhythm (SR) to guided using electroanatomic mapping (EAVM), mildly affected low‐voltage area (maLVA) may be undetected. We sought determine the optimal bipolar identify maLVA, its electrogram complexity, and implication on outcome. Methods results Left (LA) EAVMs were obtained in patients...
Patients who undergo permanent pacemaker (PPM) implantation after transcatheter aortic valve replacement (TAVR) have a worse outcome. The aim of this study was to identify risk factors outcomes in patients with post-TAVR PPM implantation.This is single-centre, retrospective consecutive underwent from 11 March 2011 9 November 2019. Clinical were evaluated by landmark analysis cut-off at 1 year the implantation. Of 1389 TAVR during duration and total 110 included final analysis. Right...
We determined the temporal stability of T wave alternans (TWA) during constant rate stimulation and dependence on heart (HR) β-adrenergic stimulation. Although it is established that exercise can provoke microvolt-level TWA in patients at risk for reentrant ventricular arrhythmias, mechanisms underlying humans are not well understood. Specifically, any given HR influence vs. sympathetic activation remain unclear. was measured prolonged fixed-rate atrial pacing multiple cycle lengths (CLs) 10...
Background— Manifest nodofascicular/ventricular (NFV) pathways are rare. Methods and Results— From 2008 to 2013, 4 cases were identified with manifest NFV from 3 centers. The clinical findings ablation sites reported. All presented a wide complex tachycardia but different QRS morphologies. Case 1 showed left bundle branch block/superior axis, case 2 right block/inferior narrow axis. Three of the tachycardias had atrioventricular dissociation ruling out extranodal accessory pathways,...
Sinoatrial Parasympathetic Innervation. Introduction : The response to sinoatrial parasympathetic nerve stimulation (shortened atrial refractoriness) was used determine the distribution of these fibers in humans. We hypothesized that, humans, nerves that innervate node also right atrium and greatest density innervation is near nodal fat pad. Methods Results Temporary epicardial wire electrodes were sutured pairs pad, high atrium, ventricle by direct visualization during coronary artery...
The mesenchymal stem cell (MSC), known to remodel in disease and have an extensive secretome, has recently been isolated from the human heart. However, effects of normal diseased cardiac MSCs on myocyte electrophysiology remain unclear. We hypothesize that inflammatory secretome (hMSCs) remodels can regulate arrhythmia substrates.hMSCs were patients with or without heart failure tissue attached extracted device leads samples taken explanted/donor hearts. Failing hMSCs nonfailing cocultured...
The cardiovascular consequences related to amyotrophic lateral sclerosis are relatively underappreciated. disease invokes a systematic degeneration of autonomic neurons leading dysfunction. We therefore hypothesized that patients with may have predilection the development cardiac conduction disorders. A 65-year-old Caucasian man advanced presented progressive dyspnea and palpitations. previous evaluation attributed his neuromuscular weakness he underwent pulmonary evaluation. Pulmonary...