A5108022519- Photosynthetic Processes and Mechanisms
- Cancer-related molecular mechanisms research
- Plant nutrient uptake and metabolism
- Plant Molecular Biology Research
- High Altitude and Hypoxia
- RNA modifications and cancer
- Sarcoma Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Protein Structure and Dynamics
- Bioinformatics and Genomic Networks
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Biosensors and Analytical Detection
- Endometrial and Cervical Cancer Treatments
- Genomics and Chromatin Dynamics
- Cancer-related Molecular Pathways
- T-cell and Retrovirus Studies
- Modular Robots and Swarm Intelligence
- Advanced biosensing and bioanalysis techniques
- Complex Network Analysis Techniques
- FOXO transcription factor regulation
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- Chromosomal and Genetic Variations
- Aortic Disease and Treatment Approaches
Peking University
2013-2024
Center for Life Sciences
2024
Tsinghua University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Northeast Petroleum University
2022
Jinan University
2021
Collaborative Innovation Center of Chemistry for Energy Materials
2021
Xiamen University
2021
Shihezi University
2019-2021
First Affiliated Hospital of Shihezi University Medical College
2021
An ultraportable POCT platform for DNA detection from clinics to agriculture environment food applications.
WD40-repeat proteins (WD40s), as one of the largest protein families in eukaryotes, play vital roles assembling protein-protein/DNA/RNA complexes. WD40s fold into similar β-propeller structures despite diversified sequences. A program WDSP (WD40 repeat Structure Predictor) has been developed to accurately identify WD40 repeats and predict their secondary structures. The method is designed specifically for by incorporating both local residue information non-local family-specific structural...
As an ancient protein family, the WD40 repeat proteins often play essential roles in fundamental cellular processes eukaryotes. Although investigations of eukaryotic have been frequently reported, prokaryotic ones remain largely uncharacterized. In this paper, we report a systematic analysis and detailed comparisons with ones. About 4,000 identified, accounting for 6.5% all WD40s. While their abundances are less than 0.1% most prokaryotes, they enriched certain species from Cyanobacteria...
Biomarkers based on DNA methylation have attracted wide attention in biomedical research due to their potential clinical value. Therefore, a sensitive and accurate method for detection is highly desirable the discovery diagnostics of human diseases, especially cancers. Here, an integrated, low-cost, portable point-of-care (POC) device presented analyze methylation, which integrates process pyrosequencing digital microfluidic chip. Without additional equipment complicated operation, droplets...
Abstract Background Rhabdomyosarcoma (RMS), a common soft-tissue malignancy in pediatrics, presents high invasiveness and mortality. However, besides known changes the PAX3/7-FOXO1 fusion gene alveolar RMS, molecular mechanisms of disease remain incompletely understood. The purpose study is to recognize potential biomarkers related with RMS analyse their mechanism, diagnosis prognostic significance. Methods Gene Expression Omnibus was used search normal striated muscle data sets....
The molecular networks underlying the lung response to hypoxia are not fully understood. We employed systems biology approaches study temporal effects of intermittent or sustained on gene expression in rat lungs. obtained profiles from rats exposed lasting 0–30 days and identified differentially expressed genes, their patterns, biological processes, regulatory critical for hypoxia. validated selected genes with quantitative real-time PCR. Intermittent induced two distinct sets lungs that...
Metabolomics and proteomics were integrated to research the molecular characterization of high-intensity interval training, revealing changes in biological pathways.
Cervical cancer (CC) is one of the highest frequently occurred malignant gynecological tumors with high rates morbidity and mortality. Here, we aimed to identify significant genes associated poor outcome. Materials methods. Differentially expressed (DEGs) between CC tissues normal cervical were picked out by GEO2R tool Venn diagram software. Database for Annotation, Visualization Integrated Discovery (DAVID) was performed analyze gene ontology (GO) Kyoto Encyclopedia Gene Genome (KEGG)...
A link prediction model for weighted networks based on Dempster–Shafer ( DS ) evidence theory and the influence of common neighbours is proposed in this paper. First, three types future FCNs their topological structures are proposed. Second, concepts endpoint weight influence, high‐strength node introduced. Then, similarity impacts current CCNs defined, respectively. Finally, two indices fused by theory. This effectively integrates multisource information completely exploits all similarity....
Background: Acquired Immunodeficiency Syndrome (AIDS) caused by Human Virus (HIV) has seriously threatened human health, so development of new, selective and safe non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) remains a high priority for medical research. Diaryltriazine (DATA) have been identified as new class potent nonnucleoside HIV-1 (RT) inhibitors. The study deals with Topomer CoMFA (Comparative Molecular Field Analysis) molecular docking to explore the important features DATA...
Introduction Glioma is a malignant tumor that recurs easily. This study aimed at investigating the biological effect of ELK3 in epithelial-mesenchymal transition (EMT) and its prognostic value. Material methods Bioinformatics analyses were performed to determine expression value ELK3. The properties glioma cells (A172 LN229) evaluated by cell counting kit-8, plate cloning transwell assays. Gene Expression Profiling Interactive Analysis (GEPIA) website was used analyze relationship between...
Abstract Background Sarcomas (SARCs) are rare, heterogeneous mesenchymal neoplasia. To understand the tumor microenviroment (TME) and identify potential biomarkers for prognosis that associated with TME of SARCs might provide effective clues immune therapy. Methods We evaluated scores stromal by using RNA sequencing dataset patients from The Cancer Genome Atlas (TCGA) database ESTIMATE algorithm. Then differentially expressed mRNAs (DEGs), miRNAs (DEMs) lncRNAs (DELs) were filtered after...