A5020575707- Cancer-related molecular mechanisms research
- Animal Disease Management and Epidemiology
- RNA modifications and cancer
- Sarcoma Diagnosis and Treatment
- Extracellular vesicles in disease
- Vector-Borne Animal Diseases
- Circular RNAs in diseases
- Viral gastroenteritis research and epidemiology
- Wound Healing and Treatments
- Brucella: diagnosis, epidemiology, treatment
- Phytochemical Studies and Bioactivities
- Polynomial and algebraic computation
- Phytochemistry and Bioactive Compounds
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Escherichia coli research studies
- Commutative Algebra and Its Applications
- Cell Adhesion Molecules Research
- Cancer Treatment and Pharmacology
- Advanced Statistical Methods and Models
- Cardiovascular Disease and Adiposity
- Microbial Metabolism and Applications
- Radiomics and Machine Learning in Medical Imaging
- Nuclear Structure and Function
Green Chemistry
2025
Sichuan University of Science and Engineering
2025
Shanghai East Hospital
2021-2025
Tongji Hospital
2009-2022
Tongji University
2016-2022
Huazhong University of Science and Technology
2009-2022
First Hospital of Qinhuangdao
2015-2021
Jilin Agricultural University
2019-2021
Weatherford College
2021
The University of Texas at Austin
2021
Cutaneous wound healing and regeneration have become a recognized health challenge in the world, which causes severe damage to mental physical of patients. Human adipose-derived mesenchymal stem cells (hADSC) play an essential role via their paracrine function. Exosomes secreted by hADSC may contribute this progress. In study, we investigated potential clinical application roles hADSC-derived exosomes (hADSC-Exo) cutaneous healing.hADSC-Exo was isolated from human ultracentrifugation. Mice...
Chronic wounds including diabetic foot ulcers are clinical emergencies that need careful management. Exosomes from human adipose-derived mesenchymal stem cells (hADSCs-Ex) a new promising cell-free therapy for the regeneration of dermal wounds. We established delayed wound healing model using female mice. A 1.5 cm2 full-thickness cutaneous was made ventrally in 6-week-old db/db After treatment with phosphate-buffered saline, recombinant epidermal growth factor, hADSCs-CM, or hADSCs-Ex three...
Background/Objectives: The hog deer (Axis porcinus) is an endangered species facing significant threats from habitat loss and fragmentation, with only captive populations remaining in China. Expanding breeding programs restoring wild are critical strategies for the species' conservation. Achieving this requires development of effective health database identification molecular biomarkers their physiological traits. Methods: In study, we present largest blood metabolomics dataset to date deer,...
Lewis acid-enabled reactions of donor-acceptor cyclopropanes (DACs) with indoline-2-thiones are reported. The reaction exhibits tunable annulation depending on the acid and substituent at N1 indoline-2-thiones. With AlCl3 as 1-isopropylindoline-2-thiones reactants, a direct ring opening DACs, followed by intramolecular nucleophilic addition/dehydration takes place leading to formation dihydro-2H-thiepino[2,3-b]indoles in moderate good yields. Using Yb(OTf)3 promoter 1-unsubstituted (3 + 2)...
Mesenchymal stem cells (MSCs) and their secretome have significant potential in promoting hair follicle development. However, the effects of MSC therapy been reported to vary due heterogeneous characteristics. Different sources MSCs or culture systems may cause heterogeneity exosomes. To define human adipose-derived exosomes (hADSC-Exos) umbilical cord-derived (hUCMSC-Exos) for improving dermal papillary cell proliferation androgenetic alopecia. We conducted liquid chromatography-mass...
Osteosarcoma is a rare malignant bone tumor in adolescents and children. Poor prognosis has always been difficult problem for patients with osteosarcoma. Recent studies have shown that infiltrating immune cells (TIICs) are associated the clinical outcome of osteosarcoma patients. The aim our research was to construct risk score model based on TIICs predict osteosarcoma.CIBERSORTX algorithm used calculate proportion 22 TIIC types samples. Kaplan-Meier curves were drawn investigate prognostic...
Background: Bluetongue caused by the bluetongue virus (BTV) is a non-contagious and an insect-borne disease mainly affecting domestic wild ruminants. in cattle associated with vesicular lesions, weight loss, low milk production, reproductive capacity. It should not be ignored as it large economic losses to livestock breeding industry China. Although many studies have investigated infection cattle, no nationwide study on prevalence of from China has yet been conducted. This meta-analysis...
Soft tissue sarcomas (STSs) are rare, heterogeneous mesenchymal neoplasias. Understanding the tumor microenvironment (TME) and identifying potential biomarkers for prognosis associated with TME of STS might provide effective clues immune therapy. We evaluated scores stromal patients by using RNA sequencing dataset from The Cancer Genome Atlas (TCGA) database ESTIMATE algorithm. Then, differentially expressed mRNAs (DEGs), miRNAs (DEMs) lncRNAs (DELs) were identified after comparing high-...
An efficient acid-catalyzed three-component cascade strategy by employing 3,3′-bis(indolyl)methanes (BIMs) as masked 1,4-nucleophiles was established for synthesizing cyclohepta[ b ]indoles under mild and eco-friendly conditions.
Background: Brucellosis, a zoonotic disease, infects various hosts, including swine and humans. It has reemerged in recent years as public health concern, current studies on brucellosis infection have been conducted worldwide. However, no meta-analyses of global published. The aim this study was to provide an overview Brucella species (spp.) worldwide the factors associated with its persistence. Results: We searched seven databases for published epidemiological pigs, Chinese National...
MiR-592 has been identified as a neural-enriched microRNA, plays an important role in mNPCs differentiation, could induce astrogliogenesis differentiation arrest or/and enhance neurogenesis vitro Previous studies showed that long noncoding RNAs (lncRNAs) were involved the neuronal development and activity. To investigate of miR-592 neurogenesis, we described expression profile lncRNAs knockout mouse embryonic stem cells (mESCs) corresponding normal mESCs by microarray. By microarray analysis...
Abstract microRNA-592 (miR-592) has been linked to neurogenesis, but the influence of miR-592 knockout in vivo remains unknown. Here, we report that represses IPC-to-mature neuron transition, impairs motor coordination and reduces social interaction. Combining RNA-seq tandem mass tagging-based quantitative proteomics analysis (TMT protein quantification) luciferase reporter assays, identified MeCP2 as direct targetgene mouse cortex. In Tg (MECP2) mice, lipofection efficiently reduced MECP2...
Lancifolide A, 4′,7-dimethoxyisorhamnetin-3-O-α-l-rhamnosyl (1å2)[α-l-arabinosyl (1å6)]-β-d-glucopyranoside, a new flavonoid glycoside, has been isolated from the flowers of Lilium lancifolium, along with five known glycosides, which were reported to be obtained for first time this plant. Their structures elucidated on basis spectroscopic methods and literature values. All components tested antifungal activity.
The security of many recently proposed cryptosystems is mainly based on the difficulty solving large multivariate quadratic equations systems. Apart from UOV schemes with proper parameter values, basic types these can be broken without great difficulty. Moreover, there are some shortages lying in examined schemes. This paper proposes a bisectional equation (BMQE) system over finite field degree q (denoted as F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Abstract Background : Large area skin trauma has always been a great challenge for both patients and clinicians. Exosomes originated from human adipose-derived mesenchymal stem cells (hADSCs) have novel promising cell-free treatment in cutaneous damage repair. Nevertheless, the low retention rate of exosomes post-transplantation vivo remains significant clinical applications. Herein, we purposed to explore potential application roles hADSCs-Exos encapsulated functional PF-127 hydrogel wound...
<title>Abstract</title> Background Circular RNAs (circRNAs) are a class of noncoding that involved in chondrogenic differentiation, and N6-methyladenosine (m<sup>6</sup>A) broadly exists circRNAs. Materials methods A joint injury model was constructed on Diannan small-ear (DSE) pigs. Transfections were using Lipofectamine 2000. Real-time quantitative PCR (qPCR), Methylated RNA immunoprecipitation qPCR (MeRIP-qPCR), western blotting analyses performed. Alcian blue staining tested the...