A5024683174- Analog and Mixed-Signal Circuit Design
- CCD and CMOS Imaging Sensors
- Machine Learning in Bioinformatics
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Fractal and DNA sequence analysis
- Bacteriophages and microbial interactions
- Advancements in Semiconductor Devices and Circuit Design
- HIV Research and Treatment
- Radio Frequency Integrated Circuit Design
- Low-power high-performance VLSI design
- Electrical and Bioimpedance Tomography
- Influenza Virus Research Studies
- Ferroelectric and Negative Capacitance Devices
- Digital Filter Design and Implementation
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- RNA Interference and Gene Delivery
- Forest, Soil, and Plant Ecology in China
- Water Quality Monitoring and Analysis
- CRISPR and Genetic Engineering
- Advanced Power Amplifier Design
- interferon and immune responses
- Medical Imaging Techniques and Applications
- Animal Virus Infections Studies
Tsinghua University
2020-2024
This article presents a bandwidth-adaptive pipelined successive approximation register (SAR) analog-to-digital converter (ADC) with cascoded floating inverter amplifier (FIA). The proposed embeds high-gain three-stage FIA in the closed-loop operation, realizing an accurate interstage gain. It features dynamically scaled bandwidth, thereby offering fast settling, good stability, high energy efficiency, and low noise simultaneously. Its fully dynamic operation enables bandwidth event rate...
Next-generation wireless standards (e.g., WiFi-7) advancing towards wider bandwidth and higher order modulation require ADCs with GHz sampling rates over 12b resolution. Although conventional pipelined can satisfy the speed resolution specifications, their power is usually too high for handset applications, which <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\leq 10\text{mW}$</tex> per channel desired. Alternatively, time-interleaved (TI)...
This work proposes a charge-domain 4-bit multiply-and-accumulate (MAC) macro for deep neural network (DNN) accelerators. The proposed requires only 1 analog to digital converter (ADC) operation the entire 512 4 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\times $ </tex-math></inline-formula> b MAC. one-shot conversion is achieved by sampling partial MAC products onto properly sized capacitors in SAR...
Activating the STING pathway in cytosol of tumor-infiltrating antigen-presenting cells (APCs) represents a promising strategy to elicit potent antitumor immune responses for cancer therapy. However, agonists are mostly small hydrophilic molecules that suffer from rapid clearance and poor cytosolic delivery following systemic administration. While various nanoparticles have been developed promote delivery, they often exhibit premature drug release during circulation. Alternatively, stable...
High-resolution ( <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$>$</tex> 100dB SNDR), kHz-BW ADCs are required by emerging Io xmlns:xlink="http://www.w3.org/1999/xlink">$\top$</tex> and smart sensing applications. These desired for their high efficiency, but low cost ease of integration also required, especially to be compatible with the advanced CMOS processes that loT processor prefers. The state-of-the-art solutions in this scenario,...
Understanding the relationships between genomic sequences is essential to classification and characterization of living beings. The classes characteristics an organism can be identified in corresponding genome space. In space, natural metric important describe distribution genomes. Therefore, similarity two biological measured. Here, we report that all viral genomes are 32-dimensional Euclidean which weighted summation distance k-mer vectors. constructed space further proves convex hull...
This work presents an energy-efficient CIM SoC with heterogeneous CPU, CIM, SIMD, DMA and COMM cores. The main contributions include: 1) A producer-consumer instruction dependency controller (PCIDC) shared multi-port SRAM to reduce SoC-level data transfer. 2) An inner-pipelined read-free digital macro achieve higher frequency. 3) parallel-to-serial (PTS) sparse architecture utilizing the low activity of partial-sum accumulation. demonstrates first digital-CIM SoC. fabricated 55nm chip...
This paper presents a 13-tap FIR filter and an IIR embedded in 10-bit SAR ADC for wireless communications chip. The can be inherently realized through reusing the capacitor array of ADC, thus improving stopband suppression shaping transition band. Besides, DC attenuation is also avoided. sampling rate loss compensated by <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$4\times $ </tex-math></inline-formula>...
Background The characterization and comparison of microbial sequences, including archaea, bacteria, viruses fungi, are very important to understand their evolutionary origin the population relationship. Most methods limited by sequence length lack generality. purpose this study is propose a general method, classification phylogeny existing datasets. Methods We present new alignment-free method represent compare biological sequences. By adding covariance between each two nucleotides,...
Mutations may produce highly transmissible and damaging HIV variants, which increase the genetic diversity, pose a challenge to develop vaccines. Therefore, it is of great significance understand how mutations drive virulence HIV. Based on 11897 reliable genomes HIV-1 retrieved from sequence Database, we analyze 12 types point mutation (A&gt;C, A&gt;G, A&gt;T, C&gt;A, C&gt;G, C&gt;T, G&gt;A, G&gt;C, G&gt;T, T&gt;A, T&gt;C, T&gt;G) multiple...
Mutation is the driving force of species evolution, which may change genetic information organisms and obtain selective competitive advantages to adapt environmental changes. It structure or function translated proteins, cause abnormal cell operation, a variety diseases even cancer. Therefore, it particularly important identify gene regions with high mutations. Mutations will changes in nucleotide distribution, can be characterized by natural vectors globally. Based on vectors, we propose...
Many loT applications require high-resolution delta-sigma modulator (DSM) ADCs with good power efficiency. To meet this demand, one current technical trend involves employing a continuous-time (CT) topology as opposed to switched-capacitor since the CT offers easy-driven and anti-aliasing features. Nevertheless, kHz-level-BW DSM often requires MΩ-range high-R resistors [1]–[3]. Using normal poly implement consumes large silicon area introduces distributed-parameter parasitic capacitance. It...
For virus classification and tracing, one idea is to generate minimal models from the gene sequences of each group for comparative analysis within between classes, as well tracing new sequences. The starting point defining a model find their longest common sequence (LCS), but this non-deterministic polynomial-time hard (NP-hard) problem. Therefore, we applied some heuristic approaches finding LCS, newer methods treating sequences, including multiple alignment (MSA) k-mer natural vector (NV)...
Abstract Understanding the differences between genomic sequences of different lives is crucial for biological classification and phylogeny. Here, we downloaded all reliable seven kingdoms determined dimensions genome space embedded in Euclidean space, along with corresponding Natural Metrics. The concept Grand Biological Universe further proposed. In grand universe, convex hulls formed by universes are mutually disjoint, groups within each kingdom disjoint. This study provides a novel...
Bacterial evolution is an important study field, biological sequences are often used to construct phylogenetic relationships. Multiple sequence alignment very time-consuming and cannot deal with large scales of bacterial genome in a reasonable time. Hence, new mathematical method, joining density vector proposed cluster bacteria, which characterizes the features coding (CDS) DNA sequence. Coding carry genetic information that can synthesize proteins. The correspondence between genomic its...
High-end mobile devices are desired to support multiple radio standards across a large bandwidth and DR span, e.g., from GSM, BLE, NB-loT 5G WiFi-6, which impose great challenges on the receiver's ADC design. Deploying specialized ADCs for every standard is beneficial in performance power efficiency, but will soon become too costly bulky as number of explodes. Multi-mode or reconfigurable promising solutions, they adapt different (i.e., BW DR) with reasonable efficiency. However, most prior...
Background: This study addresses the need for analyzing viral genome sequences and understanding their genetic relationships. The focus is on introducing a novel natural graph approach as solution. Objective: objective of this to demonstrate effectiveness advantages proposed in clustering into distinct clades, subtypes, or districts. Additionally, aim explore its interpretability, potential applications, implications pandemic control public health interventions. Methods: utilizes algorithm...
The sampling noise is a fundamental issue that limits the energy efficiency of analog-to-digital converters (ADCs). This brief gives tutorial on emerging mitigation techniques, including time-domain cancellation, frequency-domain decoupling and continuous-time (CT) ADCs obviate front-end. operation principles, limitations, future development trends with these techniques are discussed.
WRKY transcription factor family is plant-specific and WRKY53, a member of this gene family, plays significant role in plant biotic abiotic stress response leaf senescence. To explore the biological functions NtWRKY53 Nicotiana tabacum, tobacco was cloned. encoded by proved to possess highly conservative typical domain analysis. Phylogenetic collinearity analyses revealed that tabacum AtWRKY53 Arabidopsis were paralogous genes. Subcellular localization assay indicated localized cell nucleus....