Zhenzi Bai

ORCID: 0000-0003-3173-0463
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About
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Research Areas
  • Genomics, phytochemicals, and oxidative stress
  • Circular RNAs in diseases
  • Plant responses to water stress
  • Plant Stress Responses and Tolerance
  • Viral Infections and Immunology Research
  • MicroRNA in disease regulation
  • RNA regulation and disease
  • Plant nutrient uptake and metabolism
  • Extracellular vesicles in disease
  • IL-33, ST2, and ILC Pathways
  • Pancreatic function and diabetes
  • Cytomegalovirus and herpesvirus research
  • Soybean genetics and cultivation
  • Pluripotent Stem Cells Research

Jilin University
2018-2023

Union Hospital
2018-2023

Peking University
2008

Emerging evidence closely links Enterovirus 71 (EV71) infection with the generation of reactive oxygen species (ROS). Excess ROS results in apoptosis and exacerbates inflammatory reactions. The Keap1-Nrf2 axis serves as an essential oxidant counteracting pathway.The present study aimed to elucidate role pathway modulating reactions triggered by oxidative stress Vero RD cells upon EV71 infection.Elevated production was identified infected cells. percentage dead expression...

10.1186/s13099-020-00361-w article EN cc-by Gut Pathogens 2020-04-23

Accumulating evidence has shown that microRNA (miR) derived from M1 macrophage-derived exosomes can regulate the progression of hepatocellular carcinoma (HCC). However, effect miR-326 on HCC not been reported. Therefore, objective present study was to explore mechanism exosomal macrophages in regulating cell progression. RT-qPCR detected expression lines. altered by transfection, and CD206 NF-κB expression, proliferation, colony formation, migration, apoptosis invasion detected....

10.1186/s11671-020-03432-8 article EN cc-by Nanoscale Research Letters 2020-12-02

Abstract Several studies have substantiated the correlation between reactive oxygen species (ROS) and Sirtuin 1 (SIRT1). Normally, enterovirus 71 (EV71) is associated with severe clinical manifestations death. However, effect of EV71 on induction cellular death interplay ROS/SIRT1 in cell has not been confirmed yet. In current study, an increase number apoptotic cells was observed as soon infection initiated mice. Furthermore, also promoted a rise levels three commonly known proinflammatory...

10.1002/jcb.29628 article EN Journal of Cellular Biochemistry 2020-01-02
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