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Sebum Lee

ORCID: 0000-0003-3545-7310
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About
Contact & Profiles
A5076617899
Research Areas
  • Amyotrophic Lateral Sclerosis Research
  • Neurogenetic and Muscular Disorders Research
  • RNA Research and Splicing
  • Macrophage Migration Inhibitory Factor
  • Pluripotent Stem Cells Research

University of California, San Francisco
 2014-2016

San Francisco VA Medical Center
 2014

 ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects
OPENALEX - Publications 
Haiyan Qiu Sebum Lee Yulei Shang Wen-Yuan Wang Kin Fai Au and 15 more Sherry Kamiya Sami J. Barmada Steven Finkbeiner Hansen Lui Caitlin E. Carlton Amy Tang Michael C. Oldham Hejia Wang James Shorter Anthony J. Filiano Erik D. Roberson Warren G. Tourtellotte Bin Chen Li-Huei Tsai Eric J. Huang

Autosomal dominant mutations of the RNA/DNA binding protein FUS are linked to familial amyotrophic lateral sclerosis (FALS); however, it is not clear how cause neurodegeneration. Using transgenic mice expressing a common FALS-associated mutation (FUS-R521C mice), we found that mutant proteins formed stable complex with WT and interfered normal interactions between histone deacetylase 1 (HDAC1). Consequently, FUS-R521C exhibited evidence DNA damage as well profound dendritic synaptic...

10.1172/jci72723 article EN Journal of Clinical Investigation 2014-02-09
 Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis
OPENALEX - Publications 
Sebum Lee Yulei Shang Stephanie Redmond Anatoly Urisman Amy Tang and 14 more Kathy H. Li Alma L. Burlingame Ryan A. Pak Ana Jovičić Aaron D. Gitler Jinhua Wang Nathanael S. Gray William W. Seeley Teepu Siddique Eileen H. Bigio Virginia M.‐Y. Lee John Q. Trojanowski Jonah R. Chan Eric J. Huang

10.1016/j.neuron.2016.05.021 article EN publisher-specific-oa Neuron 2016-06-19
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