Background —Atherosclerosis is associated with immune responses to oxidized lipoproteins and certain microorganisms, but the role of specific immunity has remained unclear. Methods Results —To study in atherosclerosis, we crossed atherosclerosis-prone apoE —/– mice immunodeficient scid/scid mice. The offspring showed a 73% reduction aortic fatty streak lesions when compared immunocompetent –/– Transfer CD4 + T cells from / increased by 164%. This was infiltration transferred into lesions,...

Increasing evidence suggests that atherosclerosis is an inflammatory disease promoted by hypercholesterolemia. The role of adaptive immunity has been controversial, however. We hypothesized proatherogenic T cells are controlled immunoregulatory cytokines. Among them, TGF-β implied in atherosclerosis, but its mechanism action remains unclear. crossed atherosclerosis-prone ApoE-knockout mice with transgenic carrying a dominant negative receptor II cells. disrupted signaling exhibited sixfold...

Atherosclerosis is an inflammatory-fibrotic response to accumulation of cholesterol in the artery wall. In hypercholesterolemia, low density lipoproteins (LDL) accumulate and are oxidized proinflammatory compounds arterial intima, leading activation endothelial cells, macrophages, T lymphocytes. We have studied immune cell autoimmune LDL atherosclerotic apo E-knockout mice. Autoantibodies exhibited subclass specificities indicative help, increase antibody titers peripheral blood was...

Atherosclerosis is an inflammatory disease, and the involvement of immune mechanisms in disease progression increasingly recognized. Immunization with oxidized low density lipoprotein (LDL) decreases atherosclerosis several animal models. To explore humoral cellular reactions involved this protection, we immunized apolipoprotein E knockout mice either homologous plaque homogenates or malondialdehyde (MDA)-LDL. both these antigen preparations reduced lesion development. The plaques contained...

Atherosclerosis is an inflammatory disease. Several chemokines are important for monocyte/macrophage and T-cell recruitment to the lesion. CXCL16 a recently discovered chemokine that expressed in soluble transmembrane forms, ligates CXCR6 receptor, guides migration of activated Th1 Tc1 cells. It identical scavenger receptor SR-PSOX, which mediates uptake oxidized low-density lipoprotein. We investigated whether expression controlled by interferon-gamma (IFN-gamma)-cytokine abundant...

Background— Atherosclerosis is a chronic inflammatory disease characterized by massive intimal accumulation of low-density lipoprotein that triggers vascular inflammation with an autoimmune response to components. Methods and Results— To dampen the component atherosclerosis, we injected hypercholesterolemic huB100 tg × Ldlr −/− mice (mice transgenic for human apolipoprotein B100 [ApoB100] deficient receptor) intravenously dendritic cells (DCs) had been pulsed protein ApoB100 in combination...

High-amylose cereal starch has a great benefit on human health through its resistant content. In this paper, starches were isolated from mature grains of high-amylose transgenic rice line (TRS) and wild-type cultivar Te-qing (TQ) digested in vitro vivo. The structural changes digestive residues characterized using DSC, XRD, (13)C CP/MAS NMR, ATR-FTIR. TQ was very susceptible to digestion; following vivo digestion showed similar characteristics with control starch, which suggested that both...

Abstract —T cells are present in atherosclerotic lesions at all stages of development. They exhibit activation markers and particularly prominent sites plaque rupture. This suggests that T-cell–mediated immune responses involved the pathogenesis atherosclerosis. Antigen-specific T reactive with oxidized lipoproteins heat shock proteins have been isolated from plaques, indicating local clonal expansion might occur. To analyze different atherosclerosis, we used a murine model. Targeted...

Atherosclerosis is associated with immune responses to oxidized low-density lipoprotein (oxLDL). The presence of activated macrophages and T cells in lesions suggests that cell-mediated reactions are taking place during the disease process. However, role specific has remained unclear. We have previously shown transfer CD4+ from apolipoprotein E knockout mice (apoE(-/-)) into immunodeficient apoE(-/-) scid/scid accelerates disease.To test whether this effect dependent on disease-associated...

Atherosclerosis is a complex disease, bearing many of the characteristics chronic inflammatory process. Both cellular and humoral immune responses may be involved in disease development. Oxidized low-density lipoprotein (oxLDL) suggested to an autoantigen atherosclerosis. A protective effect against atherosclerosis has been demonstrated animals immunized with oxLDL. Such protection associated elevation T cell–dependent IgG antibodies In addition, it shown that immunization Freund adjuvant...

The proatherogenic effect of IL-18 is shown to be dependent on IFN-gamma production. It believed that activated T cells play a role through secretion IFN-gamma. However, recent studies in vitro have macrophages, NK cells, and even vascular smooth muscle may also secrete after stimulation by cytokines like IL-18. We therefore investigated whether other than can via under the vivo.SCID/apoE knockout mice were injected intraperitoneally with either or phosphate-buffered saline 3 times per week...

Bisphenol A (BPA) is a typical endocrine disruptor. S (BPS) has been widely used as substitute for various plastic materials due to the limited application of BPA. However, it does not mean that BPS safe lack effective evaluation BPS. In this study, clinical model Caenorhabditis elegans (C. elegans) was study effects on locomotion behavior, growth, reproduction, lifespan and antioxidant system. Our found C. exposed 0.01 μM could have significantly inhibited behavior well damaged reproductive...

Apolipoprotein E (ApoE) is synthesized by a variety of cells including macrophages. These activate T lymphocytes antigen presentation, while the T-cell cytokine, interferon-gamma, inhibits macrophage ApoE expression. proliferation in culture but its role immune responses has been unclear. The ApoE-deficient (E0) mouse permits an evaluation immunological ApoE. We have analysed to exogenous (ovalbumin) and polyclonal mitogen (concanavalin A) E0 ApoE+/+ mice. Macrophages mice stimulated...

The antidiabetic activities of bitter melon powders produced with lyophilization/superfine grinding and hot air drying/normal were investigated in vivo for selecting a suitable processing procedure. After five-week treatment, lyophilized superfine powder (BLSP) had higher activity reducing fasting blood glucose levels from 21.40 to 12.54 mmol/L, the serum insulin 40.93 30.74 mIU/L, restoring SOD compared those drying (BAP) treated group. Furthermore, BLSP protected pancreatic tissues...

Abstract BACKGROUND Barley contains a relatively high concentration of the mixed‐linkage (1 → 3) 4) β ‐glucan, which has been reported to be functional food with prebiotic potential. In current study we compared properties two neutral barley ‐glucans, obtained from raw barley: ‐glucan (RBG) and Lactobacillus plantarum dy‐1‐fermented (FBG). RESULTS Molecular characteristics revealed that molecular weight decreased 1.13 × 10 5 D 6.35 4 after fermentation. Fermentation also improved water / oil...

Ocean tides in polar regions play an important role the study of sea ice dynamics and floating shelves. The accuracy existing ocean tide models shallow waters seas is much lower than that open deep oceans. This summarized advances state-of-the-art global Antarctic Ocean, construction around Circum-Antarctica, five typical regions: Peninsula, Ross Sea, Filchner–Ronne Ice Shelf (FRIS), Weddell Amery (AIS). FES 2014, TPXO9, EOT20, CATS 2008, regional areas was evaluated using tidal records...

Remodeling of extracellular matrix (ECM) plays an important role in both atherosclerosis and aneurysm disease. Serine protease inhibitor A3 (serpinA3) is several proteases such as elastase, cathepsin G chymase derived from mast cells neutrophils. In this study, we investigated the putative serpinA3 formation. SerpinA3 was expressed endothelial medial smooth muscle human atherosclerotic lesions a 14-fold increased expression serpinA3n mRNA found Apoe-/- mice compared to lesion-free vessels....

This study aimed to evaluate the anticarcinogenic activities of aqueous extract fermented wheat germ with Lactobacillus plantarum dy-1 (LFWGE). The activities, including antiproliferative effects and induction apoptosis, were studied in human HT-29 colon cancer cells. 2,6-dimethoxybenzoquinone total phenol contents LFWGE determined by HPLC Folin-Ciocalteu method. In addition, some functional proteins separated purified gel filtration chromatography. There 21 identified LC-MS/MS. sugars...

Abstract In the past decade, mesenchymal stem cells (MSCs) have been widely used for treatment of osteoarthritis (OA), and exosomes may play a major role. Here, we acquired special kind MSCs from bone marrow surgically resected tissue hand patient with polydactyly. Experiments were focused on role polydactyly marrow-derived (pBMSCs) in osteoarthritis. The results showed that pBMSCs had greater ability than BMSCs to differentiate into chondrocytes. Mechanistically, expression BMP4 was...