A5089822999- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Breast Lesions and Carcinomas
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Immunotherapy and Biomarkers
- Clinical Nutrition and Gastroenterology
- Cancer and Skin Lesions
- Platelet Disorders and Treatments
- Amino Acid Enzymes and Metabolism
- Immune cells in cancer
- Cancer Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Blood properties and coagulation
- Epigenetics and DNA Methylation
- Head and Neck Cancer Studies
- Erythrocyte Function and Pathophysiology
- Spondyloarthritis Studies and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Cancer Mechanisms and Therapy
- Hepatitis B Virus Studies
- Medicinal Plant Pharmacodynamics Research
- Immune Response and Inflammation
- Glycosylation and Glycoproteins Research
- NF-κB Signaling Pathways
Capital Medical University
2024
Beijing Tian Tan Hospital
2024
Wuhan University
2023
Zhongnan Hospital of Wuhan University
2023
Second Affiliated Hospital of Shantou University Medical College
2018-2022
Shantou University
2018-2022
Chinese Academy of Sciences
2021-2022
Yangpu Hospital of Tongji University
2021-2022
Hefei Institutes of Physical Science
2022
Nanjing University
2022
Tumor microenvironment plays pivotal roles in carcinogenesis, cancer development and metastasis. Composition of immune cell subsets can be inferred by deconvolution gene expression profile accurately. Compositions the types including infiltrating stromal cells have been reported to associated with outcomes markers for prognosis. However, rare studies on their association response preoperative radiotherapy rectal cancer. In this paper, we deconvoluted immune/stromal composition from profiles....
The receptor tyrosine kinase Axl plays important roles in promoting cancer progression, metastasis, and drug resistance has been identified as a promising target for anticancer therapeutics. We used molecular modeling-assisted structural optimization starting with the low micromolar potency compound 9 to discover 13c, highly potent orally bioavailable inhibitor. Selectivity profiling showed that 13c could inhibit well-known oncogenic Met equal its inhibition of superfamily kinases. Compound...
Cutaneous malignant melanoma (MM) is the most type of all skin neoplasms. There wide variability in characteristics MM between patients different races. The aim present study was to investigate clinicopathological with central China and assess value specific hematological biochemical indices for predicting metastasis. data 167 from First Affiliated Hospital Zhengzhou University (Henan, China) were retrospectively analyzed compared available cBioPortal Cancer Genomics. Following analysis...
Abstract Background The benefit of adjuvant chemotherapy in invasive lobular carcinoma (ILC) is still unclear. objective the current study was to elucidate effectiveness hormone receptor (HR)-positive, human epidermal growth factor 2 (HER2)-negative, pT1b-c/N0–1/M0 ILC. Methods Based on Surveillance, Epidemiology, and End-Results (SEER) database, we identified original 12,334 HR-positive, HER2-negative, ILC patients, who were then divided into group control group. End-points overall survival...
Abstract Background To summarize the clinicopathological characteristics, prognosis, and management of breast adenosquamous carcinoma (ASC). Methods A population-based study was performed using retrospectively extracted data from Surveillance, Epidemiology, End Results database for cancer patients with histological diagnoses ASC, infiltrating duct (IDC) squamous cell (SCC) 2004 to 2016. ASC presented similar tumor size but low grade less lymph node metastasis compared IDC. expressed positive...
Objective: In order to inquire into the pathogenesis of increased platelet counts in peripheral blood patients with iron deficiency anemia (IDA), phenomenon thrombocytosis was confirmed, and then expression tubulin within platelets from IDA investigated.Methods: Peripheral samples were collected 79 divided 2 groups, group normal (34 cases), (thrombocytosis) (45 cases). Additionally, 45 healthy volunteers enrolled as a controls. Count detected by means LH-780 hematology analyzer hemocytometer...
Objective: The expression of glucocorticoid receptors within platelets from newly diagnosed Immune Thrombocytopenia (ITP) patients in the adult was investigated.Methods: GR ITP and healthy controls measured using flow cytometry. Subsequently, RNA proteins were isolated used for confirming cytometry results by RT-qPCR ELISA.Results: Flow showed that percentages expressing GRα GRβ significantly higher than those (P < 0.05). qPCR ELISA confirmed increased at both transcription protein levels...
BACKGROUND: The molecular classification of breast cancer mainly focuses on estrogen receptor (ER), Progesterone (PgR), and Human Epidermal Growth Factor Receptor 2(HER2/Neu) status detected by immunohistochemistry (IHC) analysis. β -tubulin isotype III (TUBB3) gene was thought to be a marker taxane resistance or aggressiveness. METHODS: To evaluate the clinicopathological significance TUBB3 expression in patients, we measured mRNA levels 92 patients Quantitative reverse...
Traditional preclinical experiments on brainstem gliomas mainly rely patient-derived primary cell lines, but there are problems such as low success rate in establishment and inability to preserve tumor heterogeneity, which limit the clinical transformation. As a new type of vitro model, organoids have similar structure function original tumor, requiring less tissue for cultivation, with short cycle high rate, is particularly suitable glioma biopsy. There currently no precedent successful...
This study aimed to evaluate the changes and clinical significance of thrombomodulin (TM) plasma protein C (PC) in patients with cancer before after peripherally inserted central catheter placement (PICC).The levels TM PC 35 PICC were measured by enzyme-linked immunosorbent assay, differences was analyzed.TM 3.57 ± 1.01 μg/L at 1 day catheterization, which significantly lower than value 4.41 1.26 catheterization; these values 4.30 1.81 4.73 0.97 30 90 days respectively (F = 4.14,P < 0.05)....
Objective To investigate the effect and feasibility of early enteral nutrition support on postoperative assessments clinical outcomes in children patients with congenital heart disease. Methods From October 2013 to 2014, a number 100 cases disease aged six months two years old were treated after operation. According gender, fifty randomly divided into intervened group, who program. The other control group no support. detailed project were(a) withdraw breathing machine at same day,...
Abstract Background : The benefit of adjuvant chemotherapy in invasive lobular carcinoma (ILC) is still unclear. objective the current study was to elucidate effectiveness hormone receptor (HR)-positive, human epidermal growth factor 2 (HER2)-negative, pT1b-c/N0-1/M0 ILC. Methods: Based on Surveillance, Epidemiology, and End-Results (SEER) database, we identified original 13996 HR-positive, HER2-negative, ILC patients, who were then divided into group control group. End-points overall...
To evaluate the clinical features, molecular subtypes, therapeutic strategies, and prognostic factors of occult breast cancer (OBC). Patients with T0-3/N1-3/M0 diagnosed in 2010–2018 (n = 114,303, including 691 OBC) were retrieved from Surveillance, Epidemiology, End-Results (SEER) database. The endpoints overall survival (OS) cancer-specific (BCSS). Compared non-OBC, OBC presented significantly more adverse clinicopathological features. More patients underwent breast-conserving treatment...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)