A5032397876- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Bone health and treatments
- MicroRNA in disease regulation
- Bone health and osteoporosis research
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- 3D Printing in Biomedical Research
- Circular RNAs in diseases
- Cancer Research and Treatments
- Wnt/β-catenin signaling in development and cancer
- Melanoma and MAPK Pathways
- Lung Cancer Treatments and Mutations
- Neuropeptides and Animal Physiology
- PARP inhibition in cancer therapy
- Radiopharmaceutical Chemistry and Applications
- Molecular Biology Techniques and Applications
- Pneumonia and Respiratory Infections
- Esophageal Cancer Research and Treatment
- Diet and metabolism studies
- Cancer Cells and Metastasis
- Renal and related cancers
Guangzhou University
2018-2025
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2015-2024
Shanghai University of Traditional Chinese Medicine
2015-2024
First Affiliated Hospital of GuangXi Medical University
2021-2024
Guangxi Medical University
2020-2024
Guangzhou University of Chinese Medicine
2019-2024
Fudan University
2024
Ministry of Education of the People's Republic of China
2017-2024
Jinan Central Hospital
2017-2024
Shaanxi Provincial People's Hospital
2024
Oxidative stress is a critical event in neuronal damage following seizures. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have been shown to be promising nanotherapeutic agents neurological disorders. However, the mechanism underlying MSC-EVs therapeutic efficacy for oxidative stress-induced remains poorly understood. Methods: We investigated antioxidant and restoration activities of on hippocampal neurons response H2O2 stimulation vitro seizures vivo. also explored...
Human mesenchymal stem cells (hMSCs) have wide applications in regenerative medicine but their clinical translation is largely hindered by limited production capacity of current cell expansion regime. This study utilizes a novel dispersible and dissolvable porous microcarrier tablet, 3D TableTrix™, stirred bioreactor to demonstrate scalable protocol for industrial manufacturing hMSCs. The TableTrix ready-to-use tablet that disperses into 10s 1000s microcarriers upon contact with culture...
This study was to evaluate the prognostic value of pretreatment inflammatory indexes including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), lymphocyte-to-monocyte (LMR), and systemic immune-inflammation index (SII) in colorectal cancer (CRC) patients receiving neoadjuvant chemoradiotherapy (CRT). We enrolled 98 eligible CRC divided them into high or low NLR, PLR, LMR, SII groups according their median value, respectively. Univariate multivariate analysis were performed...
Efficient and large-scale expansion of mesenchymal stem/stromal cells (MSCs) has always been a formidable challenge to researchers in cell-based therapies regenerative medicine. To reconcile major drawbacks 2D planar culturing system, we innovatively developed an automated closed industrial scale cell production (ACISCP) platform based on GMP-grade microcarrier for culture umbilical cord-mesenchymal (UCMSCs), accordance with the criteria stem bank. ACISCP system is fully which employs...
Osteosarcoma is the most common primary bone cancer in children and adolescents. In spite of aggressive treatment, osteosarcoma has a high mortality rate with minimal improvements survival over past few decades. Polyphyllin I (PPI), component traditional Chinese medicinal herb Paris polyphylla Smith, been shown to have anti-tumor properties. However, its mechanism as an anti-osteosarcoma agent not well elucidated. this study, we found that PPI suppressed cell viability, arrested cycle G2/M...
Background: As the leading primary bone cancer in adolescents and children, osteosarcoma patients with metastasis show a five-year-survival-rate of 20-30%, without improvement over past 30 years.Wnt/β-catenin is important promoting development.DKK3 Wnt/β-catenin antagonist predicted to have specific binding site 3′-UTR miR-214-3p.Methods: miR-214-3p DKK3 levels were investigated human tissues cells by RT-qPCR; prognostic importance level was determined Log-rank test; direct between...
Lipid is the building block and an important source of energy, contributing to malignant behavior tumor cells. Recent studies suggested that lipid droplets (LDs) accumulations were associated with nasopharyngeal carcinoma (NPC) progression. Solute carrier family 27 member 6 (SLC27A6) mediates cellular uptake long-chain fatty acid (LCFA), a necessary component. However, functions SLC27A6 in NPC remain unknown. Here, we found significant reduction mRNA tissues compared normal epithelia (NNE)....
With the development of society, energy application and building thermal comfort in rural residences are receiving more attention. The this survey mainly cover areas 21 prefectures Guangdong province, which 24.7% Pearl River Delta, 18.9% western Guangdong, 13.1% eastern 43.2% northern Guangdong. Rural household consumption is used for lighting equipment, appliances, cooking where equipment appliances consume electrical energy, consumes different types due to diversity types. First, there a...
Nemonoxacin is a novel nonfluorinated quinolone with excellent in vitro activity against most pathogens community-acquired pneumonia (CAP), especially Gram-positive isolates. The purpose of this study was to assess the efficacy and safety nemonoxacin compared levofloxacin patients CAP.A phase 3, multicenter, randomized (2:1) controlled trial conducted adult CAP receiving 500 mg or orally once daily for 7-10 days. Clinical, microbiological response adverse events were assessed....
Objective . To demonstrate the role of Wnt/ β -catenin canonical pathway in postmenopausal osteoporosis by evaluating serum levels patients with and analyzing their possible relationship OPG, RANKL, ratio RANKL/OPG, sclerostin, bone turnover markers. Methods 480 170 healthy women were enrolled study. Serum -catenin, sclerostin measured enzyme-linked immunosorbent assay. Bone status was assessed measuring mineral density Estradiol also detected. Results lower osteoporotic compared to...
Morphine is widely used in clinical practice for a class of analgesic drugs, long-term use morphine will cause the action tolerance. MicroRNAs have been reported to be involved tolerance.. Forty male SD rats were selected and randomly divided into 5 groups: control group, tolerance miR-365 mimic + (miR-365 mimic) inhibitor inhibitor) group negative (NC) NC) group. After administration at 0 d, 1 3 d 7 behavioral testing was performed. A dual luciferase reporter gene assay performed confirm...
The clinical evidence indicated that cyclophosphamide (CPD), one of the chemotherapy drugs, caused severe deteriorations in bones cancer patients. However, exact mechanisms by which CPD exerts effects on bone remodeling is not yet fully elucidated. Therefore, this study was performed to investigate role and potential mechanism osteoblastogenesis osteoclastogenesis. Here it found treatment (100mg/kg/day) for 7 days led osteoporosis phenotype male mice. inhibited as shown decreasing number...
The dysregulation of epigenetic modification and energy metabolism cooperatively contribute to the tumorigenesis nasopharyngeal carcinoma (NPC). However, detailed mechanisms underlying their joint contribution NPC development progression remain unclear. Here, we investigate role Acy1 Coenzyme A Acyltransferases1 (ACAT1), a key enzyme in metabolic pathway ketone bodies, proliferation metastasis elucidate molecular mechanisms. Ketogenesis, plays critical tumorigenesis. Previously, reported two...
Plasma lipidomics has been commonly used for biomarker discovery. Studies in cancer have suggested a significant alteration of circulating metabolite profiles which is correlated with characteristics and treatment outcome. However, the nasopharyngeal carcinoma (NPC) rarely studied. We previously described phenomenon lipid droplet accumulation NPC cells showed that such could be regulated by latent infection Epstein-Barr virus (EBV). Here, we compared plasma lipidome patients to healthy...
To investigate the association between surgical removal of tonsils and risk COVID-19 with different severity.
Removal of tonsils and adenoids is among the most common surgical procedures worldwide. Evidence increased risk cancer following such surgery is, however, inconclusive.We conducted a population-based, sibling-controlled cohort study 4,953,583 individuals in Sweden with follow-up during 1980-2016. History tonsillectomy, adenotonsillectomy, adenoidectomy was identified from Swedish Patient Register whereas incident cases were Cancer Register. We used Cox models to calculate hazard ratios (HR)...
Identification of biomarkers for predicting radiosensitivity would be useful administering individualized radiotherapy (RT) to patients with esophageal cancer. The aim the present study was evaluate association between cyclooxygenase-2 (COX-2), X-ray repair cross complementing group 1 (XRCC1), ras domain family (RASSF1) protein expression, clinicopathological characteristics, and survival rate in 76 squamous cell carcinoma (ESCC) who were treated RT. Positive expression COX-2, XRCC1 RASSF1...