A5032449545- Antimicrobial Resistance in Staphylococcus
- Pneumonia and Respiratory Infections
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Bacterial Identification and Susceptibility Testing
- Cytomegalovirus and herpesvirus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral-associated cancers and disorders
- Infectious Diseases and Tuberculosis
- Diagnosis and treatment of tuberculosis
- Bacterial biofilms and quorum sensing
- Lymphoma Diagnosis and Treatment
- Antibiotic Use and Resistance
- Medical Imaging and Pathology Studies
- Hepatitis B Virus Studies
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Natural product bioactivities and synthesis
- Infective Endocarditis Diagnosis and Management
- Lung Cancer Diagnosis and Treatment
- Garlic and Onion Studies
- Nosocomial Infections in ICU
- Protease and Inhibitor Mechanisms
- Lung Cancer Research Studies
- Antifungal resistance and susceptibility
Chung Shan Medical University
2015-2024
Chung Shan Medical University Hospital
2015-2024
Czech Academy of Sciences, Institute of Microbiology
2018
Buddhist Tzu Chi General Hospital
2007
Dayeh University
2007
Qingdao University
2002
Tri-Service General Hospital
2002
National Defense Medical Center
2002
Taichung Hospital
1999
Airway inflammation and remodeling in chronic asthma are characterized by airway eosinophilia, hyperplasia of goblet cells smooth muscle, subepithelial fibrosis. We examined the role leukotrienes a mouse model allergen-induced lung BALB/c mice, after intraperitoneal ovalbumin (OVA) sensitization on Days 0 14, received intranasal OVA periodically 14–75. The OVA-treated mice developed an extensive eosinophil mononuclear cell inflammatory response, hyperplasia, mucus occlusion airways. A...
Protective effects of triterpenic acids, asiatic acid (AA), glycyrrhizic (GA), or oleanolic (OA), for two human bronchial epithelial cells, 16HBE and BEAS-2B against hydrogen peroxide (H2O2) induced injury were examined. Cells pretreated by at 4 8 μmol/L followed H2O2 treatment. Results showed that significantly upregulated both Bax cleaved caspase-3 expression, also downregulated Bcl-2 expression in test cells. AA these doses retained but GA OA only reserved expression. Test acids lowered...
In this study, we examined oxidative stress and B vitamins status in non-small cell lung cancer (NSCLC) patients at different stages. NSCLC were divided into 2 groups, stage III (IIIA + IIIB, n = 27) IV (n 23). A total of 16 healthy control subjects included for comparison. Plasma levels alpha-tocopherol, beta-carotene, vitamin C, Se, Cu, Zn, reduced glutathione (GSH), oxidized (GSSG), lipid oxidation the activities peroxidase (GPX), superoxide dismutase (SOD), catalase, xanthine oxidase...
Nemonoxacin is a novel nonfluorinated quinolone with excellent in vitro activity against most pathogens community-acquired pneumonia (CAP), especially Gram-positive isolates. The purpose of this study was to assess the efficacy and safety nemonoxacin compared levofloxacin patients CAP.A phase 3, multicenter, randomized (2:1) controlled trial conducted adult CAP receiving 500 mg or orally once daily for 7-10 days. Clinical, microbiological response adverse events were assessed....
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) poses a serious threat to global public health. In an effort develop novel anti-coronavirus therapeutics and achieve prophylactics, we used gene set enrichment analysis (GSEA) for drug screening identified that Astragalus polysaccharide (PG2), mixture polysaccharides purified from membranaceus, could effectively reverse COVID-19 signature genes. Further biological assays revealed...
Determining oxacillin susceptibility using reference methods and automated systems is crucial for treating invasive infections caused by
The inhibitory effect of diallyl sulphide (DAS) and disulphide (DADS) against meticillin-resistant Staphylococcus aureus (MRSA) infection in diabetic mice was studied. influence these agents on the plasma levels fibronectin, C-reactive protein (CRP), fibrinogen, interleukin (IL)-6 tumour necrosis factor-alpha (TNF-alpha), activity plasminogen activator inhibitor-1 (PAI-1), antithrombin III (AT-III) C, MRSA-infected examined. To induce diabetes, were treated intraperitoneally with...
BACKGROUND Cytology fails to detect neoplastic cells in approximately 40% 50% of malignant pleural effusions (PEs), which commonly accompany lung adenocarcinomas. The diagnostic accuracy various tumor markers adenocarcinoma‐associated cytologically negative (LAC‐CNPEs) has been poor. current study attempted maximize efforts distinguishing LAC‐CNPEs from benign PEs. METHODS PE samples were collected 74 patients with adenocarcinoma associated positive (41 patients) and (33 PEs, 99 conditions...
Bergapten is a natural compound and has potent anticancer activities. In this study, we explored the cytotoxicity of bergapten on colorectal cancer (CRC) cell DLD-1 LoVo its underlying mechanisms. We observed that (30 50 μM) decreased viability CRC cells induced G0/G1 sub-G1 phase arrest. Furthermore, immunoblotting results indicated increased p53, phospho-p53(Ser-46), p21, PUMA, Bax, PTEN, caspase-9 caspase-3 cleavage, but cyclin E, CDK2, phosphor-AKT(Ser-473) in cells. Inhibition p53 by...
Treatment of latent tuberculosis infection (LTBI) is essential for eradicating (TB). Moreover, the patient adherence crucial in determining effectiveness TB control. Isoniazid given by DOTS daily 9 months (9H) standard treatment LTBI Taiwan. However, completion rate low due to long period and its side effects. The combined regimen using a high dose rifapentine/isoniazid once weekly 12 weeks (3HP) has been used as an alternative option United States. This may result higher rate. In this pilot...
Abstract Human papillomavirus (HPV) infection is associated with cancer and can be prevented through vaccination. Few studies from Taiwan have reported on HPV among human immunodeficiency virus (HIV)-infected subjects. The aim of this study was to examine the prevalence men who sex (MSM) without HIV in Taiwan, explore behavioral risk factors thereof. We conducted a cross-sectional during 2013 2016 collect data MSM aged 20 years or older. used questionnaire face-to-face interview,...
Weekly rifapentine and isoniazid therapy (3HP) is the most frequent treatment for latent tuberculosis infection (LTBI). However, association between major adverse drug reactions (ADRs) metabolic enzyme single-nucleotide polymorphisms (SNPs) remains unclear. In this study, 377 participants who received 3HP regimen were recruited examined genotyping of CYP5A6, CYP2B6, CYP2C19, CYP2E1, NAT2 SNPs. our 184 (48.4%) developed ADRs. Moreover, CYP2C19 rs4986893 (TT vs. CC+CT, odds ratio [OR] [95%...
Controlling the concentration of bacteria in patient rooms to prevent airborne infection is one important issues control hospitals. The effects air inlet/outlet locations, styles reclining, and change rate on removal have been studied. A real hospital isolation room was object for computation experiment. In computation, commercial CFD software used simulate steady transient motion. flow model incompressible turbulent including buoyancy effect. experiment, we fog generated by an ultrasonic...
Objective To outline the epidemiology of puerperal mastitis caused by methicillin-resistant Staphylococcus aureus (MRSA) and evaluate effect an infection control bundle on its incidence. Methods A surge in MRSA was noted a community hospital September 2009. samples from cases environment underwent typing using multilocus sequence (MLST), staphylococcal cassette chromosome mec (SCC ), gene encoding surface protein ( spa accessory regulator agr pulsed-field gel electrophoresis (PFGE). The...
Background The aim of this study was to investigate the differential plasma levels lipocalin 2 (LCN2) and its complex with MMP‐9 (where MMP is matrix metalloproteinase) before after antibiotic treatment in hospitalized adult patients community‐acquired pneumonia (CAP). Method Plasma LCN2 LCN2/MMP‐9 were measured 61 CAP 60 healthy controls using commercial enzyme‐linked immunosorbent assay (ELISA). Results A decrease number white blood cells (WBCs) neutrophils decreases C‐reactive protein...
The urokinase-type plasminogen activator receptor (uPAR) mediates various cellular activities and is involved in proteolysis, angiogenesis, inflammation. objective of this study was to investigate the association between soluble uPAR (suPAR) levels community-acquired pneumonia (CAP) severity. A commercial enzyme-linked immunosorbent assay (ELISA) performed measure plasma suPAR 67 healthy controls 75 patients with CAP. Our results revealed that were significantly elevated CAP compared...
Rapidly growing mycobacteria (RGM) can cause a broad spectrum of both community and healthcare-associated infections in humans. The aim this study was to report the clinical management outcomes successive patients following cesarean delivery with surgical site (SSIs) caused by RGM.Patients who were admitted Chung Shan Medical University Hospital, Taichung, Taiwan, between September 2006 July 2008, developed SSIs at an obstetrics hospital then referred our hospital, enrolled. Demographic...
Pulmonary mucormycosis is commonly encountered in patients with diabetic ketoacidosis, hematologic malignancies, neutropenia, organ or hematopoietic stem cell transplantation, and malignancy, but it rarely occurs high-risk systemic lupus erythematosus (SLE). We present the case of a 40-year-old SLE female fulminant pneumonia after remission nephritis treated rituximab, who developed severe pulmonary that led to her rapid death from acute respiratory failure distress syndrome. has high...