A5007581984- Gastroesophageal reflux and treatments
- Asthma and respiratory diseases
- Helicobacter pylori-related gastroenterology studies
- Obstructive Sleep Apnea Research
- Cancer-related molecular mechanisms research
- Neuroscience of respiration and sleep
- Allergic Rhinitis and Sensitization
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Eosinophilic Esophagitis
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Thermal Regulation in Medicine
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Tea Polyphenols and Effects
- Regulation of Appetite and Obesity
- Liver Disease Diagnosis and Treatment
- Dysphagia Assessment and Management
- Viral-associated cancers and disorders
- Inflammatory Bowel Disease
- Pediatric health and respiratory diseases
- Tracheal and airway disorders
- Mast cells and histamine
- RNA Research and Splicing
State Key Laboratory of Respiratory Disease
2017-2025
Guangzhou Medical University
2014-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2025
Chongqing Medical University
2025
First Affiliated Hospital of Guangzhou Medical University
2017-2024
Chengdu Second People's Hospital
2024
Xijing Hospital
2023-2024
Hunan University
2024
Chongqing City Mental Health Center
2024
Key Laboratory of Guangdong Province
2019-2023
To improve treatment outcomes in non-small cell lung cancer (NSCLC), preclinical models that can better predict individual patient response to novel therapies are urgently needed. Using freshly resected tumor tissue, we describe an optimized ex vivo explant culture model enables concurrent evaluation of NSCLC therapy while maintaining the microenvironment. We found approximately 70% primary specimens were amenable with tissue integrity intact for up 72 hours. Variations cisplatin sensitivity...
Heat shock proteins (HSPs) are a kind of molecular chaperone that helps protein folding, which is closely related to cancer. However, the association between HSPs and clear cell renal carcinoma (ccRCC) uncertain. We explored prognostic value HSP110, HSP90, HSP70 HSP60 families in ccRCC their role tumor immune microenvironment. The data obtained from Cancer Genome Atlas (TCGA) were applied determine differential expression normal tissues ccRCC. comprehensively analyzed constructed signature....
Myocardial infarction (MI) is a leading cause of morbidity and mortality worldwide, mitigating oxidative stress crucial in managing MI. Nuclear factor erythroid 2-related 2 (Nrf2) plays critical role combating facilitating cardiac remodeling post-MI. Here, we engineered Cerium oxide (CeO2) nanoparticle-guided assemblies ceria/Nrf2 nanocomposites to deliver Nrf2 plasmids. The CeO2/Nrf2 effectively activated the Nrf2/antioxidant response element (ARE) signaling pathway both vivo vitro. In...
Curcumin is the main component of Chinese herbal plant turmeric, which has been demonstrated to possess antitumor and other pharmacological properties. The aim present study was investigate effects curcumin on viability, migration apoptosis human colorectal carcinoma HCT‑116 cells, explore underlying molecular mechanisms. In addition, it investigated whether effect cells could match that chemotherapeutic drug 5‑fluorouracil (5‑FU). were treated with (10, 20 30 µM) 5‑FU (500 µM), cell...
Dietary EGCG maintains the intestinal immune homeostasis, which might play a role in preventing systemic inflammation and NAFLD.
Epithelial ovarian cancer (EOC) is one of the deadliest gynaecological malignancies worldwide. The aim this retrospective study was to create a predictive scoring model based on simple immunological and inflammatory parameters predict overall survival (OS) progression-free (PFS) in patients with EOC. We obtained 576 EOC randomly assigned them training set (n = 405) validation 171) ratio 7:3. retrospectively evaluated association between PIV OS PFS using novel immunoinflammatory marker,...
Abstract Objective Stroke is the leading cause of death and disability in China. Chinese medicine integrated with conventional now widely used prevention treatment stroke. A clinical practice guideline for application integrative stroke urgently needed. Methods This was developed following methodology procedures recommended World Health Organization Handbook Guideline Development Diagnosis Therapy Integrative Medicine. The quality evidence strength recommendations were evaluated using GRADE...
Although observational studies have reported that depression is a risk factor for gastroesophageal reflux disease, it difficult to determine the potential causal correlation. Thus, this study investigated relevance of disease using Mendelian randomization and provided new evidence their association.Based on data from UK Biobank, we assessed causality 2 diseases by analyzing 135 458 severe depressive disorder cases 41 024 cases. The inference was inverse-variance weighting, weighted median,...
The change in ambient temperature is one of the risk factors for aggravation bronchial asthma (BA). Yet, whether influences immune functions associated with allergic remains unknown. In this study, we treated asthmatic mice standard (ST, 20 °C) or thermoneutral (TT, 30 °C). results showed that airway inflammatory cell counts bronchoalveolar lavage fluid (BALF) and hyperresponsiveness (AHR) were significantly reduced TT as compared ST. imbalance Th1/Th2 response lung was improved following...
Background: Standard management has been recommended for obstructive sleep apnea (OSA) by several guidelines, but patient choice in the practical setting is unclear. Methods: A survey nested two prospective cohort studies of OSA (enrollment: 2001–2010) China. The last interview was conducted between July 2014 and May 2015, using a comprehensive 10-point questionnaire administered face-to-face or telephone interview, assessed (I) whether participant had received any treatment; (II) why he she...
Ovarian cancer is insensitive to immunotherapy and has a high mortality rate. CDK4/6 inhibitors (CDK4/6i) regulate the tumor microenvironment play an antitumor role. Our previous research demonstrated that lymphocyte aggregation (tertiary lymphoid structures, TLSs) was observed after CDK4/6i treatment. This may explain synergistic action of with anti-PD1 antibody. However, key mechanism by which promotes TLS formation not been elucidated. We examine link between prognosis. Animal models...
Causality between education and obstructive sleep apnea (OSA) is not known.Genetic variants, as instrumental variables for years of education, were derived from the Social Science Genetic Association Consortium. The outcome datasets related to OSA FinnGen research project (www.finngen.fi/en/). Inverse variance-weighted, weighted-median, Mendelian randomization-Egger analysis used estimate causal effects. To assess robustness horizontal pleiotropy significant results, leave-one-out...
The chemical compositions of black teas differ greatly and may have different health benefits; however, systematic investigations into such benefits are lacking. Here, the profiles Keemun tea (KBT) Dianhong (DBT), two common categories in China, were analyzed, their lipid-lowering effects male C57BL/6 mice fed a high-fat diet (60% energy from fat) or supplemented with 2% powder for 15 weeks investigated. compounds most crucial differentiating KBT DBT determined to be phenolic compounds,...
Rationale: Growing evidence has suggested that body water content plays a critical role in sleep apnea. However, the causal relationship not been established. Objectives: This study aimed to investigate whether increased whole-body mass is causally associated with higher risk of apnea using two-sample Mendelian randomization (MR) analysis. Methods: Body (BWM)–associated genetic instruments were extracted from genome-wide association conducted by Neale Lab, which incorporates 331,315...
It has been reported that long non-coding RNA (lncRNA) is closely related to tumor development and chemotherapy resistance. Cancer susceptibility candidate 15 (CASC15) a cancer-related lncRNA located on chromosome 6p22.3 which abnormally expressed in different malignant tumors. CASC15 involved variety of biological processes, such as cell growth, migration invasion. Various studies have shown expected become novel biomarker therapeutic target for cancer. In this review, we summarize the...