A5101405577- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Neurological Complications and Syndromes
- Cerebral Venous Sinus Thrombosis
- Neurological and metabolic disorders
- Musculoskeletal pain and rehabilitation
- Peripheral Neuropathies and Disorders
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Infectious Encephalopathies and Encephalitis
- Bacterial Infections and Vaccines
- Anesthesia and Pain Management
- Neurosurgical Procedures and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Effects and Toxicity Studies
- Moyamoya disease diagnosis and treatment
- Venous Thromboembolism Diagnosis and Management
- Pregnancy and preeclampsia studies
- Viral Infections and Immunology Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Plant-based Medicinal Research
- Head and Neck Surgical Oncology
- Cardiovascular Health and Disease Prevention
- S100 Proteins and Annexins
- Opioid Use Disorder Treatment
Sun Yat-sen University
2025
Sun Yat-sen University Cancer Center
2025
University of Washington Medical Center
2015-2024
Qingdao University
2021
Affiliated Hospital of Qingdao University
2021
Huazhong University of Science and Technology
2020
Renmin University of China
2020
Tongji Hospital
2020
Institute of Child Health
2020
Zhongnan Hospital of Wuhan University
2020
Lethal autophagy is a pathway leading to neuronal death caused by transient global ischemia. In this study, we examined the effect of Ginsenoside Rb1 (GRb1) on ischemia/reperfusion-induced autophagic and investigated role PI3K/Akt. Ischemic in vitro was induced using oxygen glucose deprivation (OGD) SH-SY5Y cells, ischemia produced two vessels occlusion rats. Cellular viability cells assessed MTT assay, CA1 evaluated Hematoxylin-eosin staining. Autophagic vacuoles were detected both...
Post dural puncture headache (PDPH) is common after placement of an intrathecal pump (ITP). Treatment refractory PDPH requires epidural blood patch (EBP) with fluoroscopic guidance to avoid damaging the catheter. However, when patients' symptoms are severe and advanced imaging resources unavailable, a safe effective alternative would need be explored. Here, we describe successful application portable X-ray in guiding EBP post-anesthesia care unit (PACU) treat patient debilitating status post...
Carotid plaque echolucency as detected by Color Doppler ultrasonography (CDUS) has been used a potential marker of vulnerability. However, contrast-enhanced ultrasound (CEUS) recently shown to be valuable method evaluate the vulnerability and neovascularization within carotid atherosclerotic plaques. The aim this study was compare CEUS CDUS in assessment using transcranial color (TCD) monitoring microembolic signals (MES) reference technique.A total 46 subjects with arterial stenosis (≥ 50%)...
Abstract Introduction Neuroprotective therapeutics achieved from animal studies have not been able to translate into clinical stroke therapies. A major reason may be that the functional tests and outcomes between trials are significantly different. Ultimately, recovery is most important for patients, but it remains challenging identify reflect human deficits. This study aimed explore whether nest‐building activity can used as a test of mouse deficit. Methods Forty‐one C57B6 male mice were...
This multicenter, randomized, double-blinded, active sham-controlled pivotal study was designed to assess the efficacy and safety of high-frequency nerve block treatment for chronic post-amputation phantom limb pain.
In previous studies of transverse sinus (TS) hypoplasia, discrepancies between TS diameter measured by magnetic resonance venography (MRV) and contrast T1-weighted (contrast T1) were observed. To investigate these discrepancies, considering that hypoplasia is associated with neurological disorders, we performed a post hoc analysis prospectively collected data from 3 case–control on transient global amnesia (TGA), monocular blindness (TMB), panic disorders while retaining the original...
Background: Previous neuroimaging and ultrasound studies suggested that compression stenosis of the internal jugular vein (IJV) in patients with transient global amnesia (TGA) may impair IJV drainage, while a patent releases intracranial pressure caused by Valsalva maneuver (VM). Methods: Seventy-nine TGA complete examination data during admission were recruited prospectively to evaluate which included time-averaged mean velocity, cross-sectional lumen area at vein's middle (J2) distal (J3)...
Our previous studies have revealed that amyloid β (Aβ)-binding alcohol dehydrogenase (ABAD) decoy peptide antagonizes Aβ42-induced neurotoxicity. However, whether it improves oxidative stress injury remains unclear. In this study, a recombinant adenovirus constitutively secreting and expressing Aβ-ABAD (rAAV/ABAD-DP-6His) was successfully constructed. results showed rAAV/ABAD-DP-6His increased superoxide dismutase activity in hydrogen peroxide-induced stress-mediated of PC12 cells. Moreover,...
Objective To assess the efficacy and safety of dl-3-n-butylphthalide injection in acute ischemic stroke patients. Methods A randomized, double-blind, double-dummy trial enrolled 552 patients China, if they were within 48 hours onset stroke, had a score from 6 to 25 on National Institutes Health Stroke Scale (NIHSS). Three hundred seventy randomly assigned receive infusion 182 received ozagrel. Results In group, NIHSS at baseline, 8th 15th days 8.64±3.03,6.45±3.88 4.71±3.90...
Accurate diagnosis of subtypes transverse sinus (TS) hypoplasia requires more expensive methods like magnetic resonance (MR) imaging. We hypothesized ultrasound findings the internal jugular vein (IJV) can be surrogate indicators for TS hypoplasia. MR images were reviewed in 131 subjects to evaluate diameter and location degree venous flow stenosis obstruction. Ultrasound parameters including cross-sectional lumen area (CSA), time-average-mean velocity (TAMV), volume (FV) at each IJV segment...