A5101366633- Tissue Engineering and Regenerative Medicine
- Congenital heart defects research
- Environmental Toxicology and Ecotoxicology
- Ferroptosis and cancer prognosis
- Cellular Mechanics and Interactions
- Cardiovascular Function and Risk Factors
- ATP Synthase and ATPases Research
- interferon and immune responses
- Aquaculture Nutrition and Growth
- Fish Biology and Ecology Studies
- RNA modifications and cancer
University of Houston
2024-2025
Hebei Agricultural University
2023
In the developing mammalian heart, endocardium and myocardium are separated by so-called cardiac jelly. Communication between is essential for morphogenesis. How membrane-localized receptors ligands achieve interaction across jelly not understood. Working in mouse morphogenesis models, we used a variety of cellular, imaging, genetic approaches to elucidate this question. We found that interacted directly through microstructures termed tunneling nanotube–like structures (TNTLs). TNTLs...
Telomerase, by safeguarding damaged telomeres and bolstering DNA damage repair, has the capacity to heighten radioresistance of tumour cells. Thus, in turn, can compromise efficacy radiotherapy (RT) radioimmunotherapy. Our previous studies have revealed that highly selective telomerase inhibitor, BIBR1532, possesses potential enhance radiosensitivity Non-small cell lung cancer (NSCLC). In this study, we delve further into impact BIBR1532 on immune activation induced RT elucidate underlying...
Abstract Aims The mechanisms regulating the cellular behaviour and cardiomyocyte organization during ventricular wall morphogenesis are poorly understood. Cardiomyocytes surrounded by extracellular matrix (ECM) interact with ECM via integrins. This study aims to determine whether how β1 integrins regulate in mouse. Methods results We applied mRNA deep sequencing immunostaining expression repertoires of α/β their ligands embryonic heart. Integrin subunit (β1) some its asymmetrically...
Background: Left ventricular noncompaction (LVNC) is a type of cardiomyopathy, which patients manifest clinical features heart failure, arrhythmias, thrombotic events, and sudden death. We previously found that the ablation Numb(Nb) , its homologue Numbl(Nl) at early stage, causes LVNC defects resulting in embryonic lethality. In this study, we mice with Nb Nl deletion later stage survive to adulthood develop toLVNC cardiomyopathy. Method: applied aMHC-Cre delete generate double knockout...
Background: Numb Family Proteins (NFPs), specifically two mammalian homologs (denoted by Nb ) and Numblike Nl ), have been evident to regulate essential cardiac functions during development. Previous studies reported NFPs as integral for epicardial cells (EpiCs) epithelial mesenchymal-transition (EMT). However, whether in epicardium EpiCs differentiation affect morphogenesis not explored. In this study, we investigated how EMT modulate development subsequently maintenance adult stages....
Introduction: Cardiomyocytes are surrounded by extracellular matrix (ECM) and interact with ECM via integrins. However, the mechanisms through which these cells organize themselves to establish tissue architecture of trabeculae ventricular wall remain inadequately elucidated. Integrins primary cell surface receptors for adhesion mediate both inside-out outside-in signal transduction pathways that control various functions, including proliferation, survival, migration, gene expression. We...
To assess the toxicological effects of heavy metal ions on fish at different flowing speeds within aquatic environments, we investigated impact Mn 2+ and flow speed physiological parameters juvenile GIFT tilapia (95.2±4.3g,15.1±0.21cm). The experiment design included four levels concentration: control group (0mg/L), 0.1mg/L, 0.5mg/L 1mg/L, as well three speeds: (0 body length/second), low (1 high-speed (2 lengths/second). main research findings were follows: had varying hematological...