A5073878575- Neurobiology and Insect Physiology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Developmental Biology and Gene Regulation
- Parkinson's Disease Mechanisms and Treatments
- Hippo pathway signaling and YAP/TAZ
- S100 Proteins and Annexins
- Lysosomal Storage Disorders Research
- Cellular transport and secretion
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurogenesis and neuroplasticity mechanisms
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Neuroscience and Neuropharmacology Research
- Genetics, Aging, and Longevity in Model Organisms
- Cancer-related gene regulation
- Signaling Pathways in Disease
- Toxoplasma gondii Research Studies
- Parasitic Infections and Diagnostics
- Microtubule and mitosis dynamics
- Plant Molecular Biology Research
- Nuclear Receptors and Signaling
- Wnt/β-catenin signaling in development and cancer
- ATP Synthase and ATPases Research
- Invertebrate Immune Response Mechanisms
ShanghaiTech University
2018-2025
National Yang Ming Chiao Tung University
2023-2025
Nu Skin (United States)
2021
Center for Excellence in Molecular Cell Science
2020
University of Chinese Academy of Sciences
2020
University of Warwick
2017
Shanghai East Hospital
2016-2017
Tongji University
2012-2017
Queen's University Belfast
2017
Institute of Molecular Biology, Academia Sinica
2008-2011
Parkinson's disease (PD) is a common neurodegenerative disorder that exhibits motor and non-motor symptoms, as well pathological hallmarks, including dopaminergic (DA) neuron death formation of α-synuclein (α-Syn) Lewy bodies. Cyclin-G-associated kinase (GAK), PD susceptibility gene identified through genome-wide association studies (GWAS), ubiquitous serine/threonine involved in clathrin uncoating, though its PD-related function remains elusive. Here, we implicate the Drosophila GAK...
Chromatin remodeling processes are among the most important regulatory mechanisms in controlling cell proliferation and regeneration. Drosophila intestinal stem cells (ISCs) exhibit self-renewal potentials, maintain tissue homeostasis, serve as an excellent model for studying growth In this study, we show that Brahma (Brm) chromatin-remodeling complex is required ISC damage-induced midgut regeneration a lineage-specific manner. ISCs enteroblasts high levels of Brm proteins; without Brm,...
The amyloid precursor protein (APP) is a broadly expressed transmembrane that has significant role in the pathogenesis of Alzheimer's disease (AD). APP can be cleaved at multiple sites to generate series fragments including β (Aβ) peptides and intracellular domain (AICD). Although Aβ have been proposed main cause AD pathogenesis, AICD underappreciated. Here we report induces AICD-dependent cell death Drosophila neuronal non-neuronal tissues. Our genetic screen identified transcription factor...
Glia contribute to the neuropathology of Parkinson disease (PD), but how they react opposingly be beneficial or detrimental under pathological conditions, like promoting eliminating SNCA/α-syn (synuclein alpha) inclusions, remains elusive. Here we present evidence that aux (auxilin), Drosophila homolog PD risk factor GAK (cyclin G associated kinase), regulates lysosomal degradation in glia. Lack glial GAK/aux increases lysosome number and size, acidification hydrolase activity, ultimately...
Neospora is a newly recognized genus of pathogenic coccidia, closely related to Toxoplasma gondii, that can cause abortion or congenital disease in variety domestic animal hosts. On the basis small-subunit rRNA gene sequences spp. and other apicomplexa oligonucleotide primers COC-1 COC-2 were used for PCR amplification conserved approximately 300 bp size. A Neospora-specific chemiluminescent probe hybridized Southern blots products from DNA but not with amplified coccidian parasites tested....
Autophagy is a major means for the elimination of protein inclusions in neurons neurodegenerative diseases such as Parkinson’s disease (PD). Yet, mechanism autophagy other brain cell type, glia, less well characterized and remains largely unknown. Here, we present evidence that PD risk factor, Cyclin-G-associated kinase (GAK)/ Drosophila homolog Auxilin (dAux), component glial autophagy. The lack GAK/dAux increases autophagosome number size adult fly glia mouse microglia, generally...
Trichomoniasis is a widespread, economically important venereal disease of cattle which causes infertility and abortion. Effective control trichomoniasis has been impeded by the insensitivity traditional diagnostic procedures, require isolation cultivation parasite, Tritrichomonas foetus, from infected cattle. We developed 0.85-kb T. foetus DNA probe identifying conserved sequences in DNAs that were isolated California, Idaho, Nevada, Costa Rica. The hybridized specifically to isolates...
Neospora sp. can cause fetal abortion or neurological disease in congenitally infected calves. Latent tissue stages cows may contribute to vertical transmission of from dam offspring multiple pregnancies. In this investigation, the polymerase chain reaction (PCR) and Neospora-specific assay were employed detect by amplification nuclear small-subunit rRNA gene sequences cattle tissues. Tissues 11 cattle, including 6 experimentally 2 naturally cows, 1 newborn calf, uninfected control evaluated...